back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and FLT4

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_011532780.1	Gene:	FLT4 / 2324	HGNCID:	3767	Length:	1440	Species:	Homo sapiens

Alignment Length:	881	Identity:	216/881 - (24%)
Similarity:	354/881 - (40%)	Gaps:	259/881 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LVLVRNAVGQAPRENATNPTLISLVRSSEKEPEQMESHRYVT----GLSEPIAME----PLTRMR 73
            |.||.|...|...:.|::|::.|           ..|.:.:|    |:..|::::    |.|..:
Human   491 LELVVNVPPQIHEKEASSPSIYS-----------RHSRQALTCTAYGVPLPLSIQWHWRPWTPCK 544

  Fly    74 LNPNPDGEITELTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVS--AVNNSRCPDAPCSEYGIK 136
                             ::.::..|.: :.||.:||...:..:.:  |||.....|. .:|: ::
Human   545 -----------------MFAQRSLRRR-QQQDLMPQCRDWRAVTTQDAVNPIESLDT-WTEF-VE 589

  Fly   137 EKNASAETHSVNLPVNPNLNVESVDCNYMFGCQYQVIVETSNAMVRRSARVY-----IP------ 190
            .||     .:|:..|..|.||.::         |:.:|  ||.:.:....:|     ||
Human   590 GKN-----KTVSKLVIQNANVSAM---------YKCVV--SNKVGQDERLIYFYVTTIPDGFTIE 638

  Fly   191 -----QCLEGK---CSCQ-------------------------------------LAPTPPKVLA 210
                 :.|||:   .|||                                     ..|....:..
Human   639 SKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEE 703

  Fly   211 VAKMLSNETISINLSILASE---------LLRKEQDSHLH---------ETLR------------ 245
            ||....:.|:|:::..:|.|         ..|:..|.|.|         |..|
Human   704 VAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNV 768

  Fly   246 --TYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVMKLGLGTQLKEKA--- 305
              :.:||..:.....||:.|           ||...|                    |:||:
Human   769 SDSLEMQCLVAGAHAPSIVW-----------YKDERL--------------------LEEKSGVD 802

  Fly   306 ------SLSLQAV-----------IIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNS---IIVM 350
                  .||:|.|           :.:..||          |.::..:..||.....|   :|::
Human   803 LADSNQKLSIQRVREEDAGRYLCSVCNAKGC----------VNSSASVAVEGSEDKGSMEIVILV 857

  Fly   351 SAMLIAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAI------EMEDNVNYVDKYVEK 409
            ...:||:....|::|:.        ..:|:.....|:|...|.|      .:|:...|:.  .:.
Human   858 GTGVIAVFFWVLLLLIF--------CNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLS--YDA 912

  Fly   410 SQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEY 474
            ||       :|.|...:.:||:||.||||:|.||:|..:.:......||||.||....|.|....
Human   913 SQ-------WEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRAL 970

  Fly   475 LAEIEMLKGVGTHHNVVSFLGCCTIKP--PYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYT 537
            ::|:::|..:|.|.|||:.||.|| ||  |.::|:|:...|||.::||..|...|....::....
Human   971 MSELKILIHIGNHLNVVNLLGACT-KPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQR 1034

  Fly   538 SCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDED 602
            .....|.........:..|.:.:.....|:|           ..|.|:..|.        .|.||
Human  1035 GRFRAMVELARLDRRRPGSSDRVLFARFSKT-----------EGGARRASPD--------QEAED 1080

  Fly   603 AFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR----HGIY 663
            .:...|..::|..::.|:|.||.||..::..||||||||:|:..:..:||.||||:|    ...|
Human  1081 LWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDY 1145

  Fly   664 TNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTIS-NDELIPFLMAGNR 727
            ....:.:|||:|::.|:|.:.||:::||:|::||:||||.:|||||||.:. |:|....|..|.|
Human  1146 VRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTR 1210

  Fly   728 LERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVL 763
            :..||:.||.:..|||.||..:|:.||.|..|.::|
Human  1211 MRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL 1246

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.