Protein Alignment CG3277 and FLT3

DIOPT Version :9

• Sequence 1: NP_608762.3
• Gene: CG3277 / 33543
• FlyBaseID: FBgn0031518
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_004110.2
• Gene: FLT3 / 2322
• HGNCID: 3765
• Length: 993
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 154/503 - (30%)
• Similarity: 239/503 - (47%)
• Gaps: 75/503 - (14%)

  Fly   278 SELNFRATPKGFEGVMKL----GLGTQLKEKASLSLQAVIIDPTGCEGPRSVTKVPVPANPVLLT 338
            |.||.....|||  ::|.    .|||        |.:.::::..|          |.|...
Human   499 STLNMSEAIKGF--LVKCCAYNSLGT--------SCETILLNSPG----------PFPFIQ---- 539

  Fly   339 EGDSVSNSIIVMSAMLIAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAIEMEDN-VNY 402
              |::|....:...:|..::|..||           ..|.:||.:...|..........|| ..|
Human   540 --DNISFYATIGVCLLFIVVLTLLI-----------CHKYKKQFRYESQLQMVQVTGSSDNEYFY 591

  Fly   403 VD----KYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLK 463
            ||    :|..|         :|.|...::.|::||.||||:|..|||..:.:...:..||||.||
Human   592 VDFREYEYDLK---------WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK 647

  Fly   464 PNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASK 528
            ....:.|....::|::|:..:|:|.|:|:.||.||:..|..:|.||...|:||:|||:.|::..:
Human   648 EKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHR 712

  Fly   529 LRN---RNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSF 590
            ...   :..|::......:..|| |.|.|:.|   ::...|..|      |..|.|.........
Human   713 TWTEIFKEHNFSFYPTFQSHPNS-SMPGSREV---QIHPDSDQI------SGLHGNSFHSEDEIE 767

  Fly   591 AETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDF 655
            .|....:.|:||.  .:|..::|..||.|:|.||.|||.:...||||||||||:...|.:||.||
Human   768 YENQKRLEEEEDL--NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDF 830

  Fly   656 GLSR----HGIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISND 716
            ||:|    ...|......:||::|::.|::.|.:|:.|||:|:||::||||.:||.:|||.|..|
Human   831 GLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVD 895

  Fly   717 -ELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVL 763
             .....:..|.::::|...|.::|.||..||..:..:||:|..|...|
Human   896 ANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	120/344 (35%)
		PTKc	430..763	CDD:270623	119/340 (35%)
FLT3	NP_004110.2	ig	256..345	CDD:278476
		PKc_like	572..947	CDD:304357	131/393 (33%)
		Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand	591..597		3/5 (60%)
		Pkinase_Tyr	610..943	CDD:285015	120/344 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910