DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and FGFR1

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_011542745.1	Gene:	FGFR1 / 2260	HGNCID:	3688	Length:	865	Species:	Homo sapiens

Alignment Length:	796	Identity:	199/796 - (25%)
Similarity:	322/796 - (40%)	Gaps:	218/796 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SSEKE-----PEQMESHRYVTGLSEPIAMEPLTRMRLNPNPDGEITEL------TTNVTLYMEKI 96
            |.|||     |.:|....|.|   .|..||    .:|:..|..:..:.      |.|.||
Human   169 SEEKETDNTKPNRMPVAPYWT---SPEKME----KKLHAVPAAKTVKFKCPSSGTPNPTL----- 221

  Fly    97 PRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNLPVNPNLNVESVD 161
                 ||   |..|..:.           ||.....|.::....|....||         |.|..
Human   222 -----RW---LKNGKEFK-----------PDHRIGGYKVRYATWSIIMDSV---------VPSDK 258

  Fly   162 CNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSI 226
            .||.  |    |||.....:..:.::.:           :..:|.:.:..|.:.:|:|:::..::
Human   259 GNYT--C----IVENEYGSINHTYQLDV-----------VERSPHRPILQAGLPANKTVALGSNV 306

  Fly   227 LASELLRKEQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEG 291
                                 :...|:..:..|.:.|   |||:.....|:...|.     .:..
Human   307 ---------------------EFMCKVYSDPQPHIQW---LKHIEVNGSKIGPDNL-----PYVQ 342

  Fly   292 VMK-LGLGTQLKEKASLSLQAVIIDPTG---CEGPRSV----------TKVPVPANPVLLTEGDS 342
            ::| .|:.|..||...|.|:.|..:..|   |....|:          ....:...|.::|....
Human   343 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLY 407

  Fly   343 VSNSIIVMSAMLIAIILAGLIMLLLRR-------------RRARTTAKLRKQEQIYIQTFATSAI 394
            :...|....|.||:.::..:|:..::.             .:...:..||:|    :...|.|:.
Human   408 LEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQ----VTVSADSSA 468

  Fly   395 EMEDNVNYV-DKYVEKSQVLGLADI----------FEVPHSAIQIGRMLGEGAFGQVHEATAINL 448
            .|...|..| ...:..|....||.:          :|:|...:.:|:.||||.||||..|.||.|
Human   469 SMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGL 533

  Fly   449 RRMR--GTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVN 511
            .:.:  ..|.||||.||.:....::::.::|:||:|.:|.|.|:::.||.||...|..:|:||.:
Human   534 DKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 598

  Fly   512 KGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDS 576
            ||||..||:.         .|......|      .|.:.:|:.|
Human   599 KGNLREYLQA---------RRPPGLEYC------YNPSHNPEEQ--------------------- 627

  Fly   577 TAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARN 641
                                           |.:|:|.:.|.|:|.||.:|..::..||||||||
Human   628 -------------------------------LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN 661

  Fly   642 VLIDSNKTLKISDFGLSR--HGI--YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEI 702
            ||:..:..:||:||||:|  |.|  |..|...:||::|::.||:.:.:|:.:||:|::||:||||
Human   662 VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEI 726

  Fly   703 GTLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVLSPKT 767
            .|||.||||.:..:||...|..|:|:::|..||.::|.:|..||...|.:||||..|.:.|.
Human   727 FTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD--- 788

  Fly   768 TYVDINSLSDDYVFPP 783
               .|.:|:.:.|..|
Human   789 ---RIVALTSNQVLHP 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	116/342 (34%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	115/338 (34%)
FGFR1	XP_011542745.1	Ig1_FGFR	73..151	CDD:143174
		IG_like	77..151	CDD:214653
		I-set	193..280	CDD:254352	26/129 (20%)
		Ig2_FGFR	196..280	CDD:143265	24/122 (20%)
		IG_like	295..391	CDD:214653	21/124 (17%)
		Ig3_FGFR	303..392	CDD:143175	19/117 (16%)
		PTKc_FGFR1	497..797	CDD:270678	121/372 (33%)
		Pkinase_Tyr	511..787	CDD:285015	116/342 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810