DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and FES

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001996.1	Gene:	FES / 2242	HGNCID:	3657	Length:	822	Species:	Homo sapiens

Alignment Length:	911	Identity:	197/911 - (21%)
Similarity:	333/911 - (36%)	Gaps:	328/911 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 EQMESHRYVTGLSEPIAMEPLTRMRLNPNPDGEITELTTNVTLYMEKIPRLQVRWQDNLPQGTSY 113
            ::::|.|...||...::::.........:||..|::....:|...|.:.||..:..::|..|
Human    36 QRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSG--- 97

  Fly   114 NVLVSAVNNSRCPDAPCSEYG--IKEKNASAETHS-------VNLPVNPNLNVESVDCNYMFGCQ 169
                           |.|:..  |:|:....:|:|       ..|....:.::|.:.      .|
Human    98 ---------------PLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLK------SQ 141

  Fly   170 YQVIVETSNAMVR------------------------------------RSARVY--------IP 190
            |:.:...|....|                                    |:|:::        :|
Human   142 YRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLP 206

  Fly   191 ------QCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLHETLRTYKM 249
                  |.|..:.:|.|.....:.|.::.::.:|.::|:.. :|:...|.:.::.....||.|..
Human   207 GLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHRE-MAAAAARIQPEAEYQGFLRQYGS 270

  Fly   250 ------------------------QLKINEETNPSLPWGGVLKHLMTRVYK----LSELNFR--- 283
                                    :|::||.|..|      ::|.:|.|..    .:|:.||
Human   271 APDVPPCVTFDESLLEEGEPLEPGELQLNELTVES------VQHTLTSVTDELAVATEMVFRRQE 329

  Fly   284 ---------------ATPKGFEGVMKLGLGTQLKEKASLSLQAVIIDPTGCEGPRSV--TKV--- 328
                           ..|:  |.|..|| ..|:.::|...||..:......:..:.:  ||:
Human   330 MVTQLQQELRNEEENTHPR--ERVQLLG-KRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHL 391

  Fly   329 -PVPANPVLLTEGDSVSNS-------------IIVMSAMLIAII--------------------- 358
             |....||||.:.|..|.|             :.::.:.:..|.
Human   392 GPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLH 456

  Fly   359 -------------LAGLIM----LLLRRRRARTTAKLRKQEQIYIQTFATSA------IEMEDNV 400
                         :|.|::    .|:|..:.       |||  |:.:.....      |:..||:
Human   457 EQLWYHGAIPRAEVAELLVHSGDFLVRESQG-------KQE--YVLSVLWDGLPRHFIIQSLDNL 512

  Fly   401 N------------YVDKYVEKSQVL----GLA-------DIFEVPHSAIQIGRMLGEGAFGQVHE 442
            .            .:|..:...|.|    |:.       |.:.:.|..:.:|..:|.|.||:|..
Human   513 YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFS 577

  Fly   443 ATAINLRRMRG-TTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMI 506
            .      |:|. .|:||||..:.....|..|::|.|..:||.. :|.|:|..:|.||.|.|..::
Human   578 G------RLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQY-SHPNIVRLIGVCTQKQPIYIV 635

  Fly   507 MEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEM 571
            ||.|..|:.|::|||   |.::||
Human   636 MELVQGGDFLTFLRT---EGARLR----------------------------------------- 656

  Fly   572 PQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRD 636
                               .:|...:|.|                   .|.||.:||.:...|||
Human   657 -------------------VKTLLQMVGD-------------------AAAGMEYLESKCCIHRD 683

  Fly   637 LAARNVLIDSNKTLKISDFGLSRH---GIY-TNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGV 697
            |||||.|:.....|||||||:||.   |:| .:...|::|::|.:.||:....|||:||:|::|:
Human   684 LAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGI 748

  Fly   698 VLWEIGTLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKV 762
            :|||..:|||||||.:||.:...|:..|.||..||:|...|:.:|.|||..||.:||:|..:|:.
Human   749 LLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQE 813

  Fly   763 L 763
            |
Human   814 L 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	108/341 (32%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	107/337 (32%)
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300		41/288 (14%)
		F-BAR_Fes	7..239	CDD:153369	33/226 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421		7/26 (27%)
		SH2_Fps_family	453..537	CDD:198224	13/92 (14%)
		Pkinase_Tyr	561..814	CDD:285015	108/341 (32%)
		PTKc_Fes	564..815	CDD:270667	109/340 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910