DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and Kit

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001116205.1	Gene:	Kit / 16590	MGIID:	96677	Length:	979	Species:	Mus musculus

Alignment Length:	442	Identity:	142/442 - (32%)
Similarity:	230/442 - (52%)	Gaps:	42/442 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 VMSAMLIAIILA----GLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAIEMEDNVNYVDKYVEK 409
            :.:.:||..::|    |:|:::|       |.|..::....:|   ...:|..:..|||  |::.
Mouse   524 LFTPLLIGFVVAAGAMGIIVMVL-------TYKYLQKPMYEVQ---WKVVEEINGNNYV--YIDP 576

  Fly   410 SQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEY 474
            :| |.....:|.|.:.:..|:.||.||||:|.||||..|.:......||||.|||:....|....
Mouse   577 TQ-LPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREAL 640

  Fly   475 LAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSC 539
            ::|:::|..:|.|.|:|:.||.||:..|.|:|.||...|:||::||  ||..|.:.::.......
Mouse   641 MSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLR--RKRDSFIFSKQEEQAEA 703

  Fly   540 RPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDS--TAHMNGIRQPHPSFAE--TTYTIVED 600
            .......:||......|..|:::|.....:...:.|.  :|.::       |:.|  .|..|:||
Mouse   704 ALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARID-------SYIERDVTPAIMED 761

  Fly   601 EDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR----HG 661
            :   |..||..:|.:|:.|:|.||.||..:...||||||||:|:...:..||.||||:|    ..
Mouse   762 D---ELALDLDDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDS 823

  Fly   662 IYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISND-ELIPFLMAG 725
            .|......:||::|::.|:|...||:.:||:|:||:.|||:.:||:||||.:..| :....:..|
Mouse   824 NYVVKGNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEG 888

  Fly   726 NRLERPEICTPQVYTIMLQCWLEEPEERPTF----DALYKVLSPKTTYVDIN 773
            .|:..||....::|.:|..||..:|.:||||    ..:.|.:|..|.::..|
Mouse   889 FRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLIEKQISDSTKHIYSN 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	121/349 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	120/345 (35%)
Kit	NP_001116205.1	ig	217..308	CDD:278476
		IG_like	221..310	CDD:214653
		Ig4_SCFR	314..414	CDD:143268
		IG_like	325..412	CDD:214653
		Ig	427..501	CDD:299845
		PTKc_Kit	556..930	CDD:270682	131/391 (34%)
		Important for interaction with phosphotyrosine-binding proteins. /evidence=ECO:0000250	571..573		2/3 (67%)
		Pkinase_Tyr	592..926	CDD:285015	120/345 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810