DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Kdr

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_034742.2	Gene:	Kdr / 16542	MGIID:	96683	Length:	1345	Species:	Mus musculus

Alignment Length:	885	Identity:	228/885 - (25%)
Similarity:	369/885 - (41%)	Gaps:	210/885 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TNPTLISLVRSSEKEPEQMESHRYVTGLSEPIAMEPLTRM---RLNPNPD-GEI----------- 82
            :|.|:|.....:..|..:.::..|...|:.||:||..:.|   .:|..|. ||.
Mouse   375 SNYTMIVGDELTIMEVTERDAGNYTVILTNPISMEKQSHMVSLVVNVPPQIGEKALISPMDSYQY 439

  Fly    83 -TELTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKE--------- 137
             |..|...|:|... |...::|...|.:..||.            ....|.|..||
Mouse   440 GTMQTLTCTVYANP-PLHHIQWYWQLEEACSYR------------PGQTSPYACKEWRHVEDFQG 491

  Fly   138 -------KNASAETHSVNLPVNPNLNVESVDCNYMFGCQ--------YQVI----VETSNAMVRR 183
                   ||..|.....|..|: .|.:::.:.:.::.|:        .:||    :......|:.
Mouse   492 GNKIEVTKNQYALIEGKNKTVS-TLVIQAANVSALYKCEAINKAGRGERVISFHVIRGPEITVQP 555

  Fly   184 SARVYIPQCLEGKCSC------------------------QLAPTPPKVLAVAK----MLSNETI 220
            :|:....:.:...|:.                        .|.|....:.|:.|    |.||.|.
Mouse   556 AAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPVCKNLDALWKLNGTMFSNSTN 620

  Fly   221 SINLSILASELLRKEQD----SHLHETLRTYKM--QLKINEETNPSLPWGGVLKHLMTRVYKLSE 279
            .|.:....:..|:.:.|    :...:|.:.:.:  ||.|.|...|.:.  |.|::..|.:.:..|
Mouse   621 DILIVAFQNASLQDQGDYVCSAQDKKTKKRHCLVKQLIILERMAPMIT--GNLENQTTTIGETIE 683

  Fly   280 LNFRA----TP--------------KGF---EGVMKLGLGTQLKEKASL-SLQAVIIDPTGC--- 319
            :...|    ||              .|.   :|...|.:....||...| :.||..:  .||
Mouse   684 VTCPASGNPTPHITWFKDNETLVEDSGIVLRDGNRNLTIRRVRKEDGGLYTCQACNV--LGCARA 746

  Fly   320 ------EGPRSVTKVPVPANPVLLTEGDSVSNSIIVMSAMLIAIILAGLIMLLLRRRRARTTAKL 378
                  ||.:..|.:.|                ||::...:||:....|::::||..:.....:|
Mouse   747 ETLFIIEGAQEKTNLEV----------------IILVGTAVIAMFFWLLLVIVLRTVKRANEGEL 795

  Fly   379 RKQEQIYIQTFATSAIEMEDNVNYVDKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEA 443
            :..   |:      :|.|:.:...:|:..|:...  .|..:|.|...:::|:.||.||||||.||
Mouse   796 KTG---YL------SIVMDPDELPLDERCERLPY--DASKWEFPRDRLKLGKPLGRGAFGQVIEA 849

  Fly   444 TAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKP--PYLMI 506
            .|..:.:......||||.||......|....::|:::|..:|.|.|||:.||.|| ||  |.::|
Mouse   850 DAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACT-KPGGPLMVI 913

  Fly   507 MEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCR--------PIMTRTNS-TSSPKSQSVNYIEL 562
            :|:...|||.:|||..|.|....:::.|.:...:        .:..|.:| |||..|.|..::|.
Mouse   914 VEFCKFGNLSTYLRGKRNEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSSQSSASSGFVEE 978

  Fly   563 KASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYI----LDNKELHNFALQIANG 623
            |:.|.                              ||:|:|.|.:    |..:.|..::.|:|.|
Mouse   979 KSLSD------------------------------VEEEEASEELYKDFLTLEHLICYSFQVAKG 1013

  Fly   624 MRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR----HGIYTNTRTRKLPLRWLSIEAIREN 684
            |.||..::..||||||||:|:.....:||.||||:|    ...|......:|||:|::.|.|.:.
Mouse  1014 MEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDR 1078

  Fly   685 VYSSKSDIWAYGVVLWEIGTLGASPYPTIS-NDELIPFLMAGNRLERPEICTPQVYTIMLQCWLE 748
            ||:.:||:|::||:||||.:|||||||.:. ::|....|..|.|:..|:..||::|..||.||.|
Mouse  1079 VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHE 1143

  Fly   749 EPEERPTFDALYKVLSPKTTYVDINSLSD--DYVFPPISE 786
            :|.:||:|..|.:.|.   ..:..|:..|  ||:..|:||
Mouse  1144 DPNQRPSFSELVEHLG---NLLQANAQQDGKDYIVLPMSE 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	126/356 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	125/352 (36%)
Kdr	NP_034742.2	Ig_3	31..105	CDD:404760
		Ig	226..327	CDD:416386
		Ig strand A	226..230	CDD:409353
		Ig strand A'	236..240	CDD:409353
		Ig strand B	242..251	CDD:409353
		Ig strand C	258..263	CDD:409353
		Ig strand C'	266..268	CDD:409353
		Ig strand D	272..280	CDD:409353
		Ig strand E	288..296	CDD:409353
		Ig strand F	306..312	CDD:409353
		Ig strand G	317..323	CDD:409353
		Ig	331..419	CDD:416386	11/43 (26%)
		Ig strand A	331..334	CDD:409353
		Ig strand A'	341..345	CDD:409353
		Ig strand B	347..358	CDD:409353
		Ig strand C	362..368	CDD:409353
		Ig strand C'	370..373	CDD:409353
		Ig strand D	378..381	CDD:409353	1/2 (50%)
		Ig strand E	383..388	CDD:409353	0/4 (0%)
		Ig strand F	396..404	CDD:409353	2/7 (29%)
		Ig strand G	410..419	CDD:409353	1/8 (13%)
		Ig_3	549..643	CDD:404760	14/93 (15%)
		I-set	665..742	CDD:400151	16/80 (20%)
		Ig strand B	682..686	CDD:409353	1/3 (33%)
		Ig strand C	695..699	CDD:409353	0/3 (0%)
		Ig strand E	718..722	CDD:409353	1/3 (33%)
		Ig strand F	732..737	CDD:409353	1/4 (25%)
		VEGFR-2_TMD	757..791	CDD:375470	9/49 (18%)
		PTKc_VEGFR2	824..1165	CDD:270681	129/374 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1272..1316
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810