DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and CSF1R

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001275634.1	Gene:	CSF1R / 1436	HGNCID:	2433	Length:	972	Species:	Homo sapiens

Alignment Length:	465	Identity:	143/465 - (30%)
Similarity:	229/465 - (49%)	Gaps:	68/465 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 GPRSVTKVPV-------PANPVLLTEGDSVSNSIIVMSAMLIAIILAGLIMLLLRRRRARTTAKL 378
            |..|...:|:       |.:..|.|.        :|::.|.|..:|..|::|||.:.:.:...::
Human   492 GSGSWAFIPISAGAHTHPPDEFLFTP--------VVVACMSIMALLLLLLLLLLYKYKQKPKYQV 548

  Fly   379 RKQEQIYIQTFATSAIEMEDNVNYVDKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEA 443
            |           ...||..:..:|.  :::.:| |...:.:|.|.:.:|.|:.||.||||:|.||
Human   549 R-----------WKIIESYEGNSYT--FIDPTQ-LPYNEKWEFPRNNLQFGKTLGAGAFGKVVEA 599

  Fly   444 TAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIME 508
            ||..|.:......||||.||....|||....::|::::..:|.|.|:|:.||.||...|.|:|.|
Human   600 TAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITE 664

  Fly   509 YVNKGNLLSYLRTVRKEASKL---------RNRNANYTSCRPIMTRTNSTSSPKSQSVN-YIELK 563
            |...|:||::||  ||..:.|         .....:|.:...........|...||.|: |:|::
Human   665 YCCYGDLLNFLR--RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMR 727

  Fly   564 ASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLE 628
            ..|.:                 .:.||:|..   ::.||...  |:.::|.:|:.|:|.||.||.
Human   728 PVSTS-----------------SNDSFSEQD---LDKEDGRP--LELRDLLHFSSQVAQGMAFLA 770

  Fly   629 EQEITHRDLAARNVLIDSNKTLKISDFGLSR----HGIYTNTRTRKLPLRWLSIEAIRENVYSSK 689
            .:...|||:||||||:.:....||.||||:|    ...|......:||::|::.|:|.:.||:.:
Human   771 SKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQ 835

  Fly   690 SDIWAYGVVLWEIGTLGASPYPTI-SNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEER 753
            ||:|:||::||||.:||.:|||.| .|.:....:..|.::.:|......:|:||..||..||..|
Human   836 SDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 900

  Fly   754 PTFDALYKVL 763
            |||..:...|
Human   901 PTFQQICSFL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	120/351 (34%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	118/347 (34%)
CSF1R	NP_001275634.1	IG_like	28..85	CDD:214653
		ig	207..293	CDD:365836
		Ig4_SCFR_like	299..400	CDD:319281
		Ig	416..495	CDD:319273	1/2 (50%)
		Regulatory juxtamembrane domain	542..574		6/45 (13%)
		PTKc_CSF-1R	543..914	CDD:133237	129/406 (32%)
		Activation loop	796..818		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..950
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810