DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Flt3

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_034359.2	Gene:	Flt3 / 14255	MGIID:	95559	Length:	1000	Species:	Mus musculus

Alignment Length:	844	Identity:	201/844 - (23%)
Similarity:	338/844 - (40%)	Gaps:	229/844 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STKVPSRIVLILLLVLV----RNAVGQAPRENATNPTLISLVRSSEKEPEQMESHRYVTGLSEPI 64
            ||...:|.::.:||..|    ||..|.....::.:|:..:||...||      .....|...|..
Mouse   302 STYSTNRTMIRILLAFVSSVGRNDTGYYTCSSSKHPSQSALVTILEK------GFINATSSQEEY 360

  Fly    65 AMEPLTRMRLNPNPDGEITELTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAP 129
            .::|..:...               ::..:..||::..|           :...|       ..|
Mouse   361 EIDPYEKFCF---------------SVRFKAYPRIRCTW-----------IFSQA-------SFP 392

  Fly   130 CSEYGIKE----------KNASAETHSVNLPVNPNLNVESVDCNYMFGCQYQVIVETSNAMVRRS 184
            |.:.|:::          ||...|                    |:|      ..|..:|...:.
Mouse   393 CEQRGLEDGYSISKFCDHKNKPGE--------------------YIF------YAENDDAQFTKM 431

  Fly   185 ARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLHETLRTYKM 249
            ..:.|.:             .|:|||.|. .|..:.|.:...|.|...:|..|...:.|
Mouse   432 FTLNIRK-------------KPQVLANAS-ASQASCSSDGYPLPSWTWKKCSDKSPNCT------ 476

  Fly   250 QLKINEETNPSLPWGGVLKHLMTRVY----KLSELNFRATPKGFEGVMKL----GLGTQLKEKAS 306
                 ||    :|.|...|....:|:    ..|.||.....||.  ::|.    .:||
Mouse   477 -----EE----IPEGVWNKKANRKVFGQWVSSSTLNMSEAGKGL--LVKCCAYNSMGT------- 523

  Fly   307 LSLQAVIIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNSIIVMSAMLIAI-ILAGLIMLLLRRR 370
             |.:.:.::..|          |.|          .:.::|...:.:.:.: .:..||:|:..:.
Mouse   524 -SCETIFLNSPG----------PFP----------FIQDNISFYATIGLCLPFIVVLIVLICHKY 567

  Fly   371 RARTTAKLRKQEQI-YIQTFATSAIEMEDNVNYVD----KYVEKSQVLGLADIFEVPHSAIQIGR 430
            :    .:.|.:.|: .||...    .:::...|||    :|..|         :|.|...::.|:
Mouse   568 K----KQFRYESQLQMIQVTG----PLDNEYFYVDFRDYEYDLK---------WEFPRENLEFGK 615

  Fly   431 MLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLG 495
            :||.||||:|..|||..:.:...:..||||.||....:.|....::|::|:..:|.|.|:|:.||
Mouse   616 VLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLG 680

  Fly   496 CCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASK-----LRNRNANYTSCRPIMTRTNSTSSPKSQ 555
            .||:..|..:|.||...|:||:|||:.|::..:     .:..|.::   .|.....:::|.|.|:
Mouse   681 ACTLSGPVYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSF---YPTFQAHSNSSMPGSR 742

  Fly   556 SVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEY-------------- 606
            .|..           .|..|..:..||             .::..||..||
Mouse   743 EVQL-----------HPPLDQLSGFNG-------------NLIHSEDEIEYENQKRLAEEEEEDL 783

  Fly   607 -ILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR----HGIYTNT 666
             :|..::|..||.|:|.||.|||.:...||||||||||:...|.:||.||||:|    ...|...
Mouse   784 NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVR 848

  Fly   667 RTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISND-ELIPFLMAGNRLER 730
            ...:||::|::.|::.|.:|:.|||:|:||::||||.:||.:|||.|..| .....:.:|.::|:
Mouse   849 GNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQ 913

  Fly   731 PEICTPQVYTIMLQCWLEEPEERPTFDALYKVL------SPKTTYVDINSLSDDYVFPPISENR 788
            |...|..:|.:|..||..:..:||:|..|...|      :.:..|.::.....::  |.|.:||
Mouse   914 PFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEEAMYQNMGGNVPEH--PSIYQNR 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	118/361 (33%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	117/357 (33%)
Flt3	NP_034359.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..67
		ig	256..346	CDD:278476	12/43 (28%)
		PKc_like	573..950	CDD:304357	129/416 (31%)
		Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding. /evidence=ECO:0000250	592..598		3/5 (60%)
		Pkinase_Tyr	611..946	CDD:285015	118/361 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	968..1000		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910