DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Flt1

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_034358.2	Gene:	Flt1 / 14254	MGIID:	95558	Length:	1333	Species:	Mus musculus

Alignment Length:	820	Identity:	212/820 - (25%)
Similarity:	358/820 - (43%)	Gaps:	208/820 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TNPTLISLVRSSEKEP-------------EQMESHRYVTGLSE--PIAMEPLTRMRLNPNPDGEI 82
            ||.|:.:||.:..:.|             .:.....|||.:..  .:::|.:.       .:||.
Mouse   516 TNKTVSTLVVADSQTPGIYSCRAFNKIGTVERNIKFYVTDVPNGFHVSLEKMP-------AEGED 573

  Fly    83 TELTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGI-KEKNASAETHS 146
            .:|:..|..::.:    .:.|           :|:..|||.      ...:.| |:|.|:.:.:|
Mouse   574 LKLSCVVNKFLYR----DITW-----------ILLRTVNNR------TMHHSISKQKMATTQDYS 617

  Fly   147 VNLPVNPNLNVESVDCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAV 211
            :.|    ||.:::|.            :|.|.....|:..:|               |...:|..
Mouse   618 ITL----NLVIKNVS------------LEDSGTYACRARNIY---------------TGEDILRK 651

  Fly   212 AKMLSNETISINLSILASELLRKEQDSHLHETLRTYKMQLKINEETN----------PSLPWGGV 266
            .::                |:|..:..||.:.|..|  ::.|:..|.          |.:.|
Mouse   652 TEV----------------LVRDSEAPHLLQNLSDY--EVSISGSTTLDCQARGVPAPQITW--- 695

  Fly   267 LKHLMTRVYKLSELNFRATPKGFEGVMKLGLGTQLKEKASLSLQAVIIDPTGCEGPRSVT-KVPV 330
                ....:|:.:          |..:.||.|     .::|.::.|..:..|....|:.. |..|
Mouse   696 ----FKNNHKIQQ----------EPGIILGPG-----NSTLFIERVTEEDEGVYRCRATNQKGAV 741

  Fly   331 PANPVLLTEG--DSVSNSIIVMSAMLIAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSA 393
            .:...|..:|  |..:..:|.::...:|..|..|::.|..|:..|::::::..   |:      :
Mouse   742 ESAAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKLKRSSSEVKTD---YL------S 797

  Fly   394 IEMEDNVNYVDKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVA 458
            |.|:.:...:|:..|:...  .|..:|.....:::|:.||.||||:|.:|:|..:::......||
Mouse   798 IIMDPDEVPLDEQCERLPY--DASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVA 860

  Fly   459 VKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIK-PPYLMIMEYVNKGNLLSYLRTV 522
            ||.||....|.|....:.|:::|..:|.|.|||:.||.||.: .|.::|:||...|||.:||::.
Mouse   861 VKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSK 925

  Fly   523 R------KEAS---KLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTA 578
            |      |:|:   :|:..     |..|.:   .....|:..||:...:.:||    .|::.|.:
Mouse   926 RDLFCLNKDAALHMELKKE-----SLEPGL---EQGQKPRLDSVSSSSVTSSS----FPEDRSVS 978

  Fly   579 HMNGIRQPHPSFAETTYTIVEDEDAFEYI---LDNKELHNFALQIANGMRFLEEQEITHRDLAAR 640
            .:.|                 |||..|..   |..::|.:::.|:|.||.||..::..|||||||
Mouse   979 DVEG-----------------DEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAAR 1026

  Fly   641 NVLIDSNKTLKISDFGLSRHGIYTN--------TRTRKLPLRWLSIEAIRENVYSSKSDIWAYGV 697
            |:|:..|..:||.||||:| .||.|        ||   |||:|::.|:|.:.|||:|||:|:|||
Mouse  1027 NILLSENNVVKICDFGLAR-DIYKNPDYVRRGDTR---LPLKWMAPESIFDKVYSTKSDVWSYGV 1087

  Fly   698 VLWEIGTLGASPYPTISNDE-LIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYK 761
            :||||.:||.||||.:..|| ....|..|.|:..||..||::|.|||.||.::|:|||.|..|.:
Mouse  1088 LLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVE 1152

  Fly   762 ---------VLSPKTTYVDINSL-----SDDYVFPPISEN 787
                     |......|:.:|::     ...|..|..||:
Mouse  1153 KLGDLLQANVQQDGKDYIPLNAILTRNSGFTYSTPTFSED 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	133/367 (36%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	132/363 (36%)
Flt1	NP_034358.2	IG_like	40..129	CDD:214653
		Ig	46..127	CDD:299845
		IG_like	144..220	CDD:214653
		IG_like	238..329	CDD:214653
		Ig	246..328	CDD:299845
		Ig	354..425	CDD:299845
		IG_like	440..553	CDD:214653	6/36 (17%)
		Ig	452..550	CDD:143165	6/33 (18%)
		IG	570..641	CDD:214652	21/107 (20%)
		IGc2	570..641	CDD:197706	21/107 (20%)
		I-set	662..749	CDD:254352	20/110 (18%)
		IGc2	677..739	CDD:197706	12/83 (14%)
		PKc_like	820..1157	CDD:304357	134/369 (36%)
		Pkinase_Tyr	828..1154	CDD:285015	133/358 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..983		9/59 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810