DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and Fgfr4

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_006517162.3	Gene:	Fgfr4 / 14186	MGIID:	95525	Length:	829	Species:	Mus musculus

Alignment Length:	671	Identity:	185/671 - (27%)
Similarity:	289/671 - (43%)	Gaps:	182/671 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 YQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRK 234
            |..:||.|...:|.|   |:...||        .:|.:.:..|.:.:|.|..:...:   |||
Mouse   249 YTCLVENSLGSIRYS---YLLDVLE--------RSPHRPILQAGLPANTTAVVGSDV---ELL-- 297

  Fly   235 EQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEGVMKLGLGT 299
                            .|:..:..|.:.|   |||::     ::..:|.|....:..|:|.   |
Mouse   298 ----------------CKVYSDAQPHIQW---LKHVV-----INGSSFGADGFPYVQVLKT---T 335

  Fly   300 QL--KEKASLSLQAVIIDPTG---CEGPRSVTKVPVPANPVLLTEGD-----------------S 342
            .:  .|...|.|:.|..:..|   |....|:......|...:|.|.|                 .
Mouse   336 DINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDLTWTTATPEARYTDIILY 400

  Fly   343 VSNSIIVMSAMLIAIILAGLIMLLLRR----RRARTTAK-----LRKQEQIYIQTFATSAIEMED 398
            ||.|::    :|:.::|||:....:.|    |:..|..|     |.:|..:..::...|::.:..
Mouse   401 VSGSLV----LLVLLLLAGVYHRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSSGKSSLSLVR 461

  Fly   399 NVNY-------------VDKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINL-- 448
            .|..             :|        |.|..::|.|...:.:|:.||||.||||..|.|..:
Mouse   462 GVRLSSSGPPLLTGLVNLD--------LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDP 518

  Fly   449 RRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKG 513
            .|...|:.||||.||.|....::|:.::|:|::|.:|.|.|:::.||.||.:.|..:|:|...||
Mouse   519 SRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKG 583

  Fly   514 NLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTA 578
            ||..:||..|.....|                  |...|:|          |...:..|
Mouse   584 NLREFLRARRPPGPDL------------------SPDGPRS----------SEGPLSFP------ 614

  Fly   579 HMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVL 643
                                             .|.:.|.|:|.||::||.::..||||||||||
Mouse   615 ---------------------------------ALVSCAYQVARGMQYLESRKCIHRDLAARNVL 646

  Fly   644 IDSNKTLKISDFGLSR--HGI--YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGT 704
            :..:..:||:||||:|  |.|  |..|...:||::|::.||:.:.||:.:||:|::|::||||.|
Mouse   647 VTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT 711

  Fly   705 LGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTF----DALYKV-LS 764
            ||.||||.|..:||...|..|:|:|||..|..::|.:|.:||...|.:||||    :||.|| |:
Mouse   712 LGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLA 776

  Fly   765 PKTTYVDINSLSDDYVFPPIS 785
            ....|:|:.     ..|.|.|
Mouse   777 VSEEYLDLR-----LTFGPFS 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	121/347 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	120/343 (35%)
Fgfr4	XP_006517162.3	IGc2	77..134	CDD:197706
		Ig	184..268	CDD:386229	7/21 (33%)
		Ig3_FGFR-2	291..378	CDD:143266	22/118 (19%)
		PTKc_FGFR4	481..794	CDD:133230	131/384 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810