DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Fgfr1

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_034336.2	Gene:	Fgfr1 / 14182	MGIID:	95522	Length:	822	Species:	Mus musculus

Alignment Length:	803	Identity:	201/803 - (25%)
Similarity:	326/803 - (40%)	Gaps:	220/803 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SSEKEPEQMESHR-----YVTGLSEPIAMEPLTRMRLNPNPDGEITEL------TTNVTLYMEKI 96
            |.|||.:..:.:|     |.|   .|..||    .:|:..|..:..:.      |.|.||
Mouse   136 SEEKETDNTKPNRRPVAPYWT---SPEKME----KKLHAVPAAKTVKFKCPSSGTPNPTL----- 188

  Fly    97 PRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNLPVNPNLNVESVD 161
                 ||   |..|..:.           ||.....|.::....|....||         |.|..
Mouse   189 -----RW---LKNGKEFK-----------PDHRIGGYKVRYATWSIIMDSV---------VPSDK 225

  Fly   162 CNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSI 226
            .||.  |    |||.....:..:.::.:           :..:|.:.:..|.:.:|:|:::..::
Mouse   226 GNYT--C----IVENEYGSINHTYQLDV-----------VERSPHRPILQAGLPANKTVALGSNV 273

  Fly   227 LASELLRKEQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEG 291
                                 :...|:..:..|.:.|   |||:.....|:...|.     .:..
Mouse   274 ---------------------EFMCKVYSDPQPHIQW---LKHIEVNGSKIGPDNL-----PYVQ 309

  Fly   292 VMK-LGLGTQLKEKASLSLQAVIIDPTG---CEGPRSV----------TKVPVPANPVLLTEGDS 342
            ::| .|:.|..||...|.|:.|..:..|   |....|:          ....:...|.::|....
Mouse   310 ILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLY 374

  Fly   343 VSNSIIVMSAMLIAIILAGLIMLLLRR-------------RRARTTAKLRKQEQIYIQTFATSAI 394
            :...|....|.||:.:|..:|:..::.             .:...:..||:|    :...|.|:.
Mouse   375 LEIIIYCTGAFLISCMLGSVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQ----VTVSADSSA 435

  Fly   395 EMEDNVNYV-DKYVEKSQVLGLADI----------FEVPHSAIQIGRMLGEGAFGQVHEATAINL 448
            .|...|..| ...:..|....||.:          :|:|...:.:|:.||||.||||..|.||.|
Mouse   436 SMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGL 500

  Fly   449 RRMR--GTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVN 511
            .:.:  ..|.||||.||.:....::::.::|:||:|.:|.|.|:::.||.||...|..:|:||.:
Mouse   501 DKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 565

  Fly   512 KGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDS 576
            ||||..||:.         .|......|      .|.:.:|:.|
Mouse   566 KGNLREYLQA---------RRPPGLEYC------YNPSHNPEEQ--------------------- 594

  Fly   577 TAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARN 641
                                           |.:|:|.:.|.|:|.||.:|..::..||||||||
Mouse   595 -------------------------------LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN 628

  Fly   642 VLIDSNKTLKISDFGLSR--HGI--YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEI 702
            ||:..:..:||:||||:|  |.|  |..|...:||::|::.||:.:.:|:.:||:|::||:||||
Mouse   629 VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEI 693

  Fly   703 GTLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYK------ 761
            .|||.||||.:..:||...|..|:|:::|..||.::|.:|..||...|.:||||..|.:
Mouse   694 FTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 758

  Fly   762 VLSPKTTYVDINSLSDDY--VFP 782
            .|:....|:|::...|.|  .||
Mouse   759 ALTSNQEYLDLSIPLDQYSPSFP 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	116/348 (33%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	115/344 (33%)
Fgfr1	NP_034336.2	Ig1_FGFR	40..118	CDD:143174
		IG_like	41..118	CDD:214653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..162		8/28 (29%)
		I-set	160..247	CDD:254352	26/129 (20%)
		Heparin-binding	160..177		4/20 (20%)
		Ig2_FGFR	163..247	CDD:143265	24/122 (20%)
		IG_like	262..358	CDD:214653	21/124 (17%)
		Ig3_FGFR	270..359	CDD:143175	19/117 (16%)
		PTKc_FGFR1	464..765	CDD:270678	119/367 (32%)
		Pkinase_Tyr	478..754	CDD:285015	116/342 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	782..822		201/803 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810