DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Flt3

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001094292.1	Gene:	Flt3 / 140635	RGDID:	61308	Length:	1000	Species:	Rattus norvegicus

Alignment Length:	819	Identity:	194/819 - (23%)
Similarity:	326/819 - (39%)	Gaps:	194/819 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RIVLILLLVLVRNAVGQAPRENATNPTLISLVRSSEKEPEQMESHRYVTGLSEPIAMEPLTRMRL 74
            ||:|..:..:.||..|.....::.:|:..:||...||      .....|...|...::|..:...
  Rat   311 RILLAFVSSVGRNNTGYYTCSSSKHPSQTALVTILEK------GFINATSSQEEYEIDPYEKFCF 369

  Fly    75 NPNPDGEITELTTNVTLYMEKIPRLQVRW----------QDNLPQGTSYNVLVSAVNNSRCPDAP 129
                           ::..:..|:::.:|          |..|..|.|.:......||.
  Rat   370 ---------------SVRFKAYPQIRCKWTFSQTSFPCEQSGLEDGYSISKFCDHKNNP------ 413

  Fly   130 CSEYGIKEKNASAETHSVNLPVNPNLNVESVDCNYMFGCQYQVIVETSNAMVRRSARVY-IPQCL 193
             .||....:|..|:...:.:     ||:..         :.||:...|.:.....:..| :|...
  Rat   414 -GEYIFHGENDDAQFTKMFI-----LNIRR---------KPQVLANASASQASCFSDGYPLPNWT 463

  Fly   194 EGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLHETLRTYKMQLKINEETN 258
            ..|||                                                         :.:
  Rat   464 WKKCS---------------------------------------------------------DKS 471

  Fly   259 PS----LPWGGVLKHLMTRVY----KLSELNFRATPKGFEGVMKL----GLGTQLKEKASLSLQA 311
            |:    :|.|...|....:|:    ..|.||.....:||  ::|.    .:||        |.:.
  Rat   472 PNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGRGF--LVKCCAYNSMGT--------SCET 526

  Fly   312 VIIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNSIIVMSAMLIAIILAGLIMLLLRRRRARTTA 376
            ::::..|               |.|..: |::|....:.......::|..||....::
  Rat   527 ILLNSPG---------------PFLFIQ-DNISFYATIGLCPPFIVVLTVLICHKYKK------- 568

  Fly   377 KLRKQEQI-YIQTFATSAIEMEDNVNYVD----KYVEKSQVLGLADIFEVPHSAIQIGRMLGEGA 436
            :.|.:.|: .||...    .:::...|:|    :|..|         :|.|...::.|::||.||
  Rat   569 QFRYESQLQMIQVTG----PLDNEYFYIDFRDYEYDLK---------WEFPRENLEFGKVLGSGA 620

  Fly   437 FGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKP 501
            ||:|..|||..:.:...:..||||.||......|....:||::|:..:|.|.|:|:.||.||:..
  Rat   621 FGRVMNATAYGISKTGVSIQVAVKMLKEKADRCEREALMAELKMMTHLGHHDNIVNLLGACTLSG 685

  Fly   502 PYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASS 566
            |..:|.||...|:||:|||:.|::..:      .:|.   |....|.:..|..||.:...:..|.
  Rat   686 PVYLIFEYCCHGDLLNYLRSKREKFHR------TWTE---IFKEHNFSFYPTFQSHSNSSMPGSR 741

  Fly   567 QTIEMPQEDSTAHMNG--IRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEE 629
            :....|..|..:..||  |........|....:.|:|:....:|..::|..||.|:|.||.|||.
  Rat   742 EVQIYPPVDQVSGFNGNSIHSEGNIEYENQKRLEEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEF 806

  Fly   630 QEITHRDLAARNVLIDSNKTLKISDFGLSR----HGIYTNTRTRKLPLRWLSIEAIRENVYSSKS 690
            :...||||||||||:...|.:||.||||:|    ...|......:||::|::.|::.|.:|:.||
  Rat   807 KSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKS 871

  Fly   691 DIWAYGVVLWEIGTLGASPYPTISND-ELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERP 754
            |:|:||::||||.:||.:|||.|..| .....:.:|.::|:|...|.::|.:|..||..:..:||
  Rat   872 DVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEEIYFVMQSCWAFDSRKRP 936

  Fly   755 TFDALYKVLSPKTTYVD---INSLSDDYVF--PPISENR 788
            :|..|...|..:....:   ..::..|...  |.|.:||
  Rat   937 SFPNLTSFLGCQLAEAEAAMYQNMGGDVPLEHPAIYQNR 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	120/343 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	119/339 (35%)
Flt3	NP_001094292.1	ig	255..345	CDD:278476	9/33 (27%)
		PKc_like	572..949	CDD:304357	130/398 (33%)
		Pkinase_Tyr	610..945	CDD:285015	120/343 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010