Protein Alignment CG3277 and Csk

DIOPT Version :9

• Sequence 1: NP_608762.3
• Gene: CG3277 / 33543
• FlyBaseID: FBgn0031518
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_001291690.1
• Gene: Csk / 12988
• MGIID: 88537
• Length: 450
• Species: Mus musculus
• Alignment Length: 546
• Identity: 137/546 - (25%)
• Similarity: 215/546 - (39%)
• Gaps: 166/546 - (30%)

  Fly   284 ATPKGFEGVMKLGL-GTQLKE----KAS-LSLQAVIIDPTGCEGPRSVTKVP-VPANPVLLTEGD 341
            |.|.|.|.:.|... ||..::    |.. |::.||..||...:....|.:.. :|||.|...||.
Mouse     7 AWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71

  Fly   342 SVSNSIIVM-----------SAMLIAIILAGLIMLLLRRRRART--------------------- 374
            .....:.:|           :..|:.....||.::     |..|
Mouse    72 KAGTKLSLMPWFHGKITREQAERLLYPPETGLFLV-----RESTNYPGDYTLCVSCEGKVEHYRI 131

  Fly   375 ---TAKLRKQEQIY-------IQTFATSA-------IE---MEDNVNYVDKYVEKSQVLGLADIF 419
               .:||...|::|       ::.:.|.|       |:   ||..|...|::......|.:.:
Mouse   132 MYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKE-- 194

  Fly   420 EVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGV 484
                  :::.:.:|:|.||.|      .|...||.. ||||.:|.:..|.   .:|||..::..:
Mouse   195 ------LKLLQTIGKGEFGDV------MLGDYRGNK-VAVKCIKNDATAQ---AFLAEASVMTQL 243

  Fly   485 GTHHNVVSFLGCCTIKPPYLMIM-EYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNS 548
             .|.|:|..||....:...|.|: ||:.||:|:.|||:        |.|:
Mouse   244 -RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS--------RGRS--------------- 284

  Fly   549 TSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKEL 613
                                                                      :|....|
Mouse   285 ----------------------------------------------------------VLGGDCL 291

  Fly   614 HNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRHGIYTNTRTRKLPLRWLSI 678
            ..|:|.:...|.:||.....||||||||||:..:...|:|||||::....|.. |.|||::|.:.
Mouse   292 LKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-TGKLPVKWTAP 355

  Fly   679 EAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIML 743
            ||:||..:|:|||:|::|::||||.:.|..|||.|...:::|.:..|.:::.|:.|.|.||.:|.
Mouse   356 EALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK 420

  Fly   744 QCWLEEPEERPTFDALYKVLSPKTTY 769
            .||..:...||||..|.:.|....|:
Mouse   421 NCWHLDAATRPTFLQLREQLEHIKTH 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	97/337 (29%)
		PTKc	430..763	CDD:270623	97/333 (29%)
Csk	NP_001291690.1	Interaction with PTPN22. /evidence=ECO:0000269|PubMed:8890164	9..70		17/60 (28%)
		SH3_CSK	11..67	CDD:212703	16/55 (29%)
		SH2_csk_like	78..175	CDD:198190	14/101 (14%)
		PTKc_Csk	188..443	CDD:133213	99/355 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910