DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and Flt4

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_446104.2	Gene:	Flt4 / 114110	RGDID:	621737	Length:	1363	Species:	Rattus norvegicus

Alignment Length:	821	Identity:	202/821 - (24%)
Similarity:	328/821 - (39%)	Gaps:	230/821 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KVPSRIVL------ILLLVLVRNAVGQAPRENATNPTLISLVRSSEKEPEQMESHRYVTGLSEPI 64
            |..|::|:      .:...:|.|.|||..|......|.|....|.|.||.:
  Rat   516 KTVSKLVIQDANVSAMYKCVVFNKVGQDERLIYFYVTTIPDGFSIESEPSE-------------- 566

  Fly    65 AMEPLTRMRLNPNPDGEITELTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAP 129
              :||         :|:...|:.....|..:    .:||         |.:.:|.:::::
  Rat   567 --DPL---------EGQSVRLSCRADNYTYE----HLRW---------YRLNLSTLHDAQ----- 602

  Fly   130 CSEYGIKEKNASAETHSVNLPVNPNLNVESVDCN--YMFGCQYQVIVETSNAMVRRSARVYIPQC 192
                                 .||.|    :||.  ::|....:..:|.:....|.:
  Rat   603 ---------------------GNPLL----LDCKNVHLFATPLEANLEEAEPGARHA-------- 634

  Fly   193 LEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASE---------LLRKEQDSHLHETLRTYK 248
                                      |:|:|:..:|.|         ..|:.||.|.|      |
  Rat   635 --------------------------TLSLNIPRVAPEDEGDYVCEVQDRRNQDKHCH------K 667

  Fly   249 MQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGF----------EGVMKLGLGTQLKE 303
            ..|.:.....|.|...  |..|:..|  ...|..|....|.          |.:::...|..|.:
  Rat   668 KYLSVQALEAPRLTQN--LTDLLVNV--SDSLEMRCPVAGAHVPSIVWYKDERLLEKESGIDLAD 728

  Fly   304 -KASLSLQAV-----------IIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNS---IIVMSAM 353
             ...||:|.|           :.:..||          |.::..:..||.....|   :|::...
  Rat   729 SNQRLSIQRVREEDAGRYLCSVCNAKGC----------VNSSASVAVEGSEDKGSMEIVILIGTG 783

  Fly   354 LIAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAI------EMEDNVNYVDKYVEKSQV 412
            :||:....|::|:.        ..:::.....|:|...|.|      .:|:...|:...|.:
  Rat   784 VIAVFFWVLLLLIF--------CNMKRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDVSQ--- 837

  Fly   413 LGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAE 477
                  :|.|...:.:||:||.||||:|.||:|..:.:......||||.||....|.|....::|
  Rat   838 ------WEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSE 896

  Fly   478 IEMLKGVGTHHNVVSFLGCCTIKP--PYLMIMEYVNKGNLLSYLRTVR--------KEASKLRNR 532
            :::|..:|.|.|||:.||.|| ||  |.::|:|:...|||.::||..|        |...:.|..
  Rat   897 LKILIHIGNHLNVVNLLGACT-KPNGPLMVIVEFCKYGNLSNFLRVKRETFDPYAEKSPEQRRRF 960

  Fly   533 NANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTI 597
            .|.....:....|..||.  ::....::..|.|::                |.|.         :
  Rat   961 RAMVEGAKADRRRLGSTD--RALFTRFLMGKGSAR----------------RAPF---------V 998

  Fly   598 VEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR--- 659
            .|.||.:...|..::|..::.|:|.||.||..::..||||||||:|:..:..:||.||||:|
  Rat   999 QEAEDLWLSPLTMEDLVCYSFQVALGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIY 1063

  Fly   660 -HGIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTIS-NDELIPFL 722
             ...|....:.:|||:|::.|:|.:.||:::||:|::||:||||.:|||||||.:. |:|....|
  Rat  1064 KDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRL 1128

  Fly   723 MAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVL 763
            ..|.|:..||:.||.:..||..||..:|:.||.|..|.::|
  Rat  1129 KDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEIL 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	122/351 (35%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	121/347 (35%)
Flt4	NP_446104.2	Ig_2	137..220	CDD:404734
		IgI_VEGFR	230..329	CDD:409448
		Ig strand B	248..252	CDD:409448
		Ig strand C	263..267	CDD:409448
		Ig strand E	293..297	CDD:409448
		Ig strand F	307..312	CDD:409448
		Ig strand G	320..323	CDD:409448
		Ig	331..418	CDD:416386
		Ig strand A	332..337	CDD:409353
		Ig strand A'	342..347	CDD:409353
		Ig strand B	349..360	CDD:409353
		Ig strand C	364..370	CDD:409353
		Ig strand C'	372..375	CDD:409353
		Ig strand D	378..380	CDD:409353
		Ig strand E	382..387	CDD:409353
		Ig strand F	395..403	CDD:409353
		Ig strand G	409..418	CDD:409353
		IG_like	570..663	CDD:214653	22/169 (13%)
		Ig strand B	574..578	CDD:409353	1/3 (33%)
		Ig strand C	587..591	CDD:409353	2/12 (17%)
		Ig strand E	636..640	CDD:409353	1/3 (33%)
		Ig strand F	650..655	CDD:409353	0/4 (0%)
		IGc2	693..755	CDD:197706	10/61 (16%)
		Ig strand B	695..699	CDD:409353	1/3 (33%)
		Ig strand C	708..712	CDD:409353	0/3 (0%)
		Ig strand E	731..735	CDD:409353	1/3 (33%)
		Ig strand F	745..750	CDD:409353	0/4 (0%)
		VEGFR-2_TMD	770..804	CDD:375470	6/41 (15%)
		PKc_like	837..1175	CDD:419665	125/370 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1289..1330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810