DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3277 and fgfr3

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	XP_012812743.1	Gene:	fgfr3 / 100196923	XenbaseID:	XB-GENE-479255	Length:	829	Species:	Xenopus tropicalis

Alignment Length:	798	Identity:	201/798 - (25%)
Similarity:	332/798 - (41%)	Gaps:	224/798 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 TELTTNVTLYMEKIP---------------RLQVRWQDNLPQGTSYNVLVSAVNNS---RCPDA- 128
            ||:..|.|:.:..:|               |...||..  |:.....:......|:   |||.|
Frog   134 TEILRNFTIRVTDLPSSGDDEDDDDEETEDREPPRWTQ--PEKMDKKLTAVPAANTIRFRCPAAG 196

  Fly   129 ---PCSEYGIKEKNASAETHSVNLPVNP---NLNVESV---DCNYMFGCQYQVIVETSNAMVRRS 184
               |...:....|....|.....:.:..   :|.:|||   |..     .|..:||.....:|::
Frog   197 NPTPTIHWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDKG-----NYTCVVENKYGSIRQT 256

  Fly   185 ARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLHETLRTYKM 249
            .::.:           |..:..:.:..|.:.:|:|:.|.            .|...|
Frog   257 YQLDV-----------LERSSHRPILQAGLPANQTVVIG------------SDVEFH-------- 290

  Fly   250 QLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFEG------VMKLGLGTQLKEKASLS 308
             .|:..:..|.:.|   |||:        |:|  .:..|.:|      :.....||::  ..:||
Frog   291 -CKVYSDAQPHIQW---LKHV--------EVN--GSKYGPDGDPYVTVLQSFTNGTEV--DTTLS 339

  Fly   309 LQAVIIDPTG---CEGPRSVTKV----------PVPANPV-LLTEGDSVSNSIIVMSAMLIAIIL 359
            |:.|.....|   |.....:...          |..|.|| ..|...|.|.:::::.:::...||
Frog   340 LKNVTETHEGQYVCRANNFIGVAEASFWLHIYKPASAEPVEKPTTTSSSSTTVLIVVSVITGFIL 404

  Fly   360 AGLIMLLLR----RRRARTTAKLR-------KQEQIYIQTFATSAIEMEDNVNYVD-KYVEKSQV 412
            ..:|.:..|    .::|.:...:.       |::|:.::    |...|..|...|. .::..|..
Frog   405 LVIIFVTYRVKVPSKKAMSAPPVHKVSKFPLKRQQVSLE----SNSSMNSNTPLVRITHLSSSDG 465

  Fly   413 LGLADI----------FEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGT--TIVAVKQLKPN 465
            ..||::          :|:..:.:.:|:.||||.||||..|.||.:.:.|..  ..||||.||.:
Frog   466 TMLANVSELGLPLDPKWELLRTRLTLGKPLGEGCFGQVVMAEAIGIEKERPNKPVTVAVKMLKDD 530

  Fly   466 PKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLR 530
            ....::::.::|:||:|.:|.|.|:::.||.||...|..:::||.:||||..||:..|
Frog   531 ATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLKARR------- 588

  Fly   531 NRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTY 595
                                   ...::|     |..|.::|.|..|.
Frog   589 -----------------------PPGMDY-----SFDTCKIPAEQLTF----------------- 608

  Fly   596 TIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR- 659
                           |:|.:.|.|:|.||.:|..|:..||||||||||:..:..:||:||||:|
Frog   609 ---------------KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARD 658

  Fly   660 -HGI--YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPF 721
             |.|  |..|...:||::|::.||:.:.:|:.:||:|:|||:|||..|||.||||.|..:||...
Frog   659 IHNIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSYGVLLWETFTLGGSPYPGIPVEELFKL 723

  Fly   722 LMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTF----DALYKVLSPKTT--YVDIN------- 773
            |..|:|:::|..||.::|.||.:||...|.:||||    :.|.:||:..:|  |:|::
Frog   724 LKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSVPFEQYS 788

  Fly   774 ----------SLSDDYVF 781
                      |..||.||
Frog   789 PACQDSHSTCSSGDDSVF 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	118/346 (34%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	117/342 (34%)
fgfr3	XP_012812743.1	IGc2	74..129	CDD:197706
		Ig2_FGFR	177..261	CDD:143265	17/88 (19%)
		Ig3_FGFR	284..371	CDD:319280	20/122 (16%)
		PTKc_FGFR3	476..809	CDD:173652	129/398 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910