DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3277 and fgfr4

DIOPT Version :9

Sequence 1:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_571505.1	Gene:	fgfr4 / 100000160	ZFINID:	ZDB-GENE-980526-488	Length:	922	Species:	Danio rerio

Alignment Length:	663	Identity:	170/663 - (25%)
Similarity:	279/663 - (42%)	Gaps:	181/663 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 YQVIVETSNAMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRK 234
            |..:||.....:   |..|:...||        .:|.:.:..|.:..|.|     :|:..:.
Zfish   333 YSCVVENKYGSI---AHTYLLDVLE--------RSPHRPILQAGLPKNTT-----AIVGGDA--- 378

  Fly   235 EQDSHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELN-FRATPKG--FEGVMKLG 296
                         :...|:..:..|.:.|   |||:        |:| .|..|.|  :..::|.|
Zfish   379 -------------QFLCKVYSDAQPHIQW---LKHI--------EMNGSRYGPDGIPYVKIVKTG 419

  Fly   297 LGTQLKEKASLSLQAVIIDPTG---CEGPRSVTKVPVPANPVLLTEGDSVS---------NSIIV 349
             ...:.|...|.|..:.::..|   |....|:......|...:|:|.|...         ..||:
Zfish   420 -SLNMSEVEVLYLTNISMEDAGEYSCLAGNSIGFSHQSAWLTVLSEEDVAKEVDLMEAKYTDIII 483

  Fly   350 MSAMLIAIILAGLIMLLLR-----------------------RRR--------ARTTAKLRKQEQ 383
            .::..:|:::|.:|::|.|                       ||:        .:::|.|.:..:
Zfish   484 YASGFLALVMAIVIVVLCRMQVHPSREPFDTLPVQKLSKFPLRRQYSVESNSSGKSSASLMRVAR 548

  Fly   384 IYIQTFATSAIEMEDNVNYVDKYVEKSQVLGLADIFEVPHSAIQIGRMLGEGAFGQV--HEATAI 446
            :........|..||..:.|...:             |.|...:.:|:.||||.||||  .||..|
Zfish   549 LSSSCSPMLAGVMEFELPYDPDW-------------EFPRENLTLGKPLGEGCFGQVVRAEAYGI 600

  Fly   447 NLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVN 511
            |.........||||.||.:....::|:.::|:|::|.:..|.|:::.||.||...|..:::||.:
Zfish   601 NKENQDHMATVAVKMLKDDATDKDLADLISEMELMKVMDKHKNIINLLGVCTQDGPLYVLVEYAS 665

  Fly   512 KGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDS 576
            ||:|..|||..|..       ..:||                            ....::|:|..
Zfish   666 KGSLREYLRARRPP-------GMDYT----------------------------FDVTKVPEEQL 695

  Fly   577 TAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARN 641
            |.                                |:|.:.|.|:|.||.:|..:...||||||||
Zfish   696 TF--------------------------------KDLVSCAYQVARGMEYLASKRCIHRDLAARN 728

  Fly   642 VLIDSNKTLKISDFGLSR--HGI--YTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEI 702
            ||:..:..:||:||||:|  |.|  |..|...::|::|::.||:.:.||:.:||:|::||::|||
Zfish   729 VLVTEDNVMKIADFGLARGVHQIDYYKKTTNGRMPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI 793

  Fly   703 GTLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVLSPKT 767
            .|||.||||.|..:||...|..|:|:::|..||.::|..|.:||...|.:||||..|.:.|...
Zfish   794 FTLGGSPYPGIPVEELFKLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEELDRV- 857

  Fly   768 TYVDINSLSDDYV 780
                :.|:||:|:
Zfish   858 ----LVSISDEYL 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	113/342 (33%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	112/338 (33%)
fgfr4	NP_571505.1	IG_like	44..135	CDD:214653
		Ig	52..136	CDD:299845
		IG_like	150..224	CDD:214653
		IGc2	156..212	CDD:197706
		Ig2_FGFR	268..352	CDD:143265	5/21 (24%)
		IG_like	273..352	CDD:214653	5/21 (24%)
		IG_like	367..461	CDD:214653	23/126 (18%)
		Ig3_FGFR-2	375..462	CDD:143266	20/114 (18%)
		PTKc_FGFR4	565..877	CDD:133230	121/387 (31%)
		Pkinase_Tyr	578..854	CDD:285015	113/342 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810