Protein Alignment CG15406 and SLC2A3

DIOPT Version :10

• Sequence 1: NP_608761.2
• Gene: CG15406 / 33542
• FlyBaseID: FBgn0031517
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 112/423 - (26%)
• Similarity: 189/423 - (44%)
• Gaps: 51/423 - (12%)

  Fly    68 AVISIGGISGNFSFSYLMNRFGRKVS---IYALAVPHTCIWFLFYFAQSIEWLYVARVFAGLTGG 129
            |:.|:||:.|:||....:|||||:.|   :..|||...|...|...|:|:|.|.:.|:..||..|
Human    68 AIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCG 132

  Fly   130 GMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHIAYHVI-------PCAVVGLPV 187
            .....:|::||||:..::||   :|.||. ..||:||.:|:.......|       | .::|..:
Human   133 LCTGFVPMYIGEISPTALRG---AFGTLN-QLGIVVGILVAQIFGLEFILGSEELWP-LLLGFTI 192

  Fly   188 LYVLLATR----YPEPPQQLIRWKREEEAEKSLRYYRRCDGPNVSKEEERAYQKHFDEMRLAIQQ 248
            |..:|.:.    .||.|:.|:..::|||..|.: ..|.....:||::        ..||:....:
Human   193 LPAILQSAALPFCPESPRFLLINRKEEENAKQI-LQRLWGTQDVSQD--------IQEMKDESAR 248

  Fly   249 QNNDTDDNGLSMSDFLTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQLDPNTNTII 313
            .:.:.....|.:  |......:.:...:||.::...:|..|...|.:.||.....| :|...||.
Human   249 MSQEKQVTVLEL--FRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQ-EPIYATIG 310

  Fly   314 IGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGTSAFGLYAFYAEEQKVDL---SAFSAWLPV 375
            .|.|..:.|:.|::||:|.||:.|.::...|          .||.:....|.|   ..::....|
Human   311 AGVVNTIFTVVSLFLVERAGRRTLHMIGLGG----------MAFCSTLMTVSLLLKDNYNGMSFV 365

  Fly   376 TLMAFIIFIA--NVGVISVTMVVLVEILPQKIR--AVATSFCLGCLSFFAFASLKTFPLMMFHLG 436
            .:.|.::|:|  .:|...:...::.|:..|..|  |:|.:.|....|.|....|  ||....:||
Human   366 CIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLL--FPSAAHYLG 428

  Fly   437 LAATMWFCAAVSVICLFYVVVCLEETKGRSMYD 469
            ....:.|...: :..|.:....:.||:||:..|
Human   429 AYVFIIFTGFL-ITFLAFTFFKVPETRGRTFED 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15406	NP_608761.2	MFS_GLUT6_8_Class3_like	19..469	CDD:340916	111/421 (26%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	109/417 (26%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)