Protein Alignment CG9663 and ABCG1

DIOPT Version :10

• Sequence 1: NP_608760.2
• Gene: CG9663 / 33541
• FlyBaseID: FBgn0031516
• Length: 808
• Species: Drosophila melanogaster
• Sequence 2: XP_024307909.1
• Gene: ABCG1 / 9619
• HGNCID: 73
• Length: 786
• Species: Homo sapiens
• Alignment Length: 855
• Identity: 295/855 - (34%)
• Similarity: 437/855 - (51%)
• Gaps: 162/855 - (18%)

  Fly     4 WSLASAVSPNVTGGDVIRLNHLKSSSETHLPSRGSGTGSGALPRPTTPVPSKKLSSKRPPHLTLN 68
            | |..||:|......|:|.|     ..|::||..|||    |......|.:....:....|:.:.
Human    44 W-LQMAVAPGHLRAWVMRNN-----VTTNIPSAFSGT----LTHEEKAVLTVFTGTATAVHVQVA 98

  Fly    69 IKAKSHDAPLAETENTVLSTS------ESVYGTPLGA--TPVSS----------PANQSQRSQAS 115
            ..|.      |:.|::|..|.      |:|..:.|..  .|:|.          |:|:..::.|:
Human    99 ALAS------AKLESSVFVTDCVSCKIENVCDSALQGKRVPMSGLQGSSIVIMPPSNRPLKASAA 157

  Fly   116 ------QHSDESRNTSSTATSG-------------GSIFP----HEQYKTIKKINIGFENIRYTT 157
                  |......:....|.||             |..||    .|.|||:
Human   158 SCTWSVQVQGGPHHLGVVAISGKVLSAAHGAGRAYGWGFPGDPMEEGYKTL-------------- 208

  Fly   158 KFGVFQRETKDVLMGLTGYFKSGELSAVIGPSGAGKSTLLNILSGYTTYGFTGDFRVNGNRRDLK 222
                        |.|::|.|.||||.|::||||||||||:|||:||...|..|...:||..|||:
Human   209 ------------LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 261

  Fly   223 AFKSNVAFIRQDTSLQAFLSVKEAMHFAANLKIGTHMTHSEK----RERVKCILEAIGMYENRHT 283
            .|:....:|.||..|...|:|:|||..:|:||:      .||    ||.||.||.|:|:....:|
Human   262 CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKL------QEKDEGRREMVKEILTALGLLSCANT 320

  Fly   284 RTGQLSGGQKKRLAIALELVNNPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICTIHQPS 348
            |||.|||||:|||||||||||||||:..||||:||||.:..|:::|:|.||..||::||||||||
Human   321 RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 385

  Fly   349 ALTFAMFDHLYAIGEGKCIYAGGAQNLLPFLGALNLHCPESYNPADYLMEIATHDYDTAEDNQLE 413
            |..|.:||.||.:.:|:|:|.|...||:|:|..|.|:||..:||||::||:|:.:|    .:|..
Human   386 AKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEY----GDQNS 446

  Fly   414 KLVALMDNGR-NEDYRQSKTARVAQLAAMKKVDQLMAAGLITPVTAPVMSTSVPAHFMQGNTFKP 477
            :||..:..|. :.|:::.                                       :.|:.
Human   447 RLVRAVREGMCDSDHKRD---------------------------------------LGGDA--- 469

  Fly   478 LTPINELSSRVWDSQTAGIGNAGSCCKPKKKNKSRPAIELDPSHL--CKRQNIYATPFYRQLSIL 540
                 |::..:|...:..:          |:.|....:..|.|.:  |   :.::.....|..||
Human   470 -----EVNPFLWHRPSEEV----------KQTKRLKGLRKDSSSMEGC---HSFSASCLTQFCIL 516

  Fly   541 LVRTFLLIWRDSSLTTMRFAIHLITGILIGTLYFGIGNDAAQTLNIFRYLFYTIMFIMYCAFSGI 605
            ..||||.|.|||.||.:|...|:..|:|||.||.||||:|.:.|:...:||::::|:|:.|....
Human   517 FKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPT 581

  Fly   606 LVKFPLEFPIVSREHFNRWYSLRAYYVAITLADLPIQIICSALFIVPTYLMTQQPLELWRFGMFF 670
            ::.||||..:..|||.|.||||:|||:|.|:||:|.||:....:....|.||.||.:..||.:|.
Human   582 VLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFA 646

  Fly   671 LIVFVTALVSQSIGLAVGAA-LSLKLGSILGPFFICPFLQFSGFFLMEKDAPVFLRWMFDISFLK 734
            .:..:|:||:||:||.:||| .||::.:.:||....|.|.|||||:.....|.:|:||..||:::
Human   647 ALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVR 711

  Fly   735 YSLEGATMAIFGYDREPLACN-ELYCHLRHPQFILKSLDMANGNYTLALIFLFGVLVFLRILAFY 798
            |..||..::|:|.|||.|.|: :..||.:..:.||:.||:.|....|..|.|....:.||::|::
Human   712 YGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYF 776

  Fly   799 IMSFRLRLFR 808
            ::.:::|..|
Human   777 VLRYKIRAER 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	3a01204	149..808	CDD:273361	253/667 (38%)
ABCG1	XP_024307909.1	3a01204	202..786	CDD:273361	257/679 (38%)