Protein Alignment CG9663 and ABCG2

DIOPT Version :10

• Sequence 1: NP_608760.2
• Gene: CG9663 / 33541
• FlyBaseID: FBgn0031516
• Length: 808
• Species: Drosophila melanogaster
• Sequence 2: NP_004818.2
• Gene: ABCG2 / 9429
• HGNCID: 74
• Length: 655
• Species: Homo sapiens
• Alignment Length: 703
• Identity: 187/703 - (26%)
• Similarity: 331/703 - (47%)
• Gaps: 106/703 - (15%)

  Fly   129 TSGGSIFPHEQYKTIKKINIG----FENIRYTTKF--GVF---QRETKDVLMGLTGYFKSGELSA 184
            |:|   ||......:|....|    |.||.|..|.  |..   :...|::|..:.|..|.| |:|
Human    17 TNG---FPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNA 77

  Fly   185 VIGPSGAGKSTLLNILSG-YTTYGFTGDFRVNGNRRDLKAFKSNVAFIRQDTSLQAFLSVKEAMH 248
            ::||:|.|||:||::|:. ....|.:||..:||..|... ||.|..::.||..:...|:|:|.:.
Human    78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPAN-FKCNSGYVVQDDVVMGTLTVRENLQ 141

  Fly   249 FAANLKIGTHMTHSEKRERVKCILEAIGMYENRHTRTGQ-----LSGGQKKRLAIALELVNNPPV 308
            |:|.|::.|.||:.||.||:..:::.:|:.:...::.|.     :|||::||.:|.:||:.:|.:
Human   142 FSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSI 206

  Fly   309 LILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICTIHQPSALTFAMFDHLYAIGEGKCIYAGGAQ 373
            |.||||||||||.|:|.::.|||:::.:|||:|.:||||....|.:||.|..:..|:.::.|.||
Human   207 LFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQ 271

  Fly   374 NLLPFLGALNLHCPESYNPADYLMEIATHDYDTAEDNQLEKLVALMDNGRNEDYRQSKTARVAQL 438
            ..|.:..:...||....||||:.::|...| .||        |||   .|.||:      :..::
Human   272 EALGYFESAGYHCEAYNNPADFFLDIINGD-STA--------VAL---NREEDF------KATEI 318

  Fly   439 AAMKKVDQLMAAGLITPVTAPVMSTSVPAHFMQGNTFKPLTPINELSSRVWDSQTAGIGNAGSCC 503
            ....|.|:        |:...:....|.:.|.:    :....:::||.
Human   319 IEPSKQDK--------PLIEKLAEIYVNSSFYK----ETKAELHQLSG----------------- 354

  Fly   504 KPKKKNKSRPAIELDPSHLCKRQNIYATPFYRQLSILLVRTFLLIWRDSSLTTMRFAIHLITGIL 568
             .:||.|.....|:.          |.|.|..||..:..|:|..:..:...:..:..:.::.|::
Human   355 -GEKKKKITVFKEIS----------YTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLV 408

  Fly   569 IGTLYFGIGNDAAQTLNIFRYLFYTIMFIMYCAFSGILVKFPLEFPIVSREHFNRWYSLRAYYVA 633
            ||.:|||:.||:....|....||:......:.:.|.:.: |.:|..:...|:.:.:|.:.:|::.
Human   409 IGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSSYFLG 472

  Fly   634 ITLAD-LPIQIICSALFIVPTYLMT-QQPLELWRFGMFFLIVFVTALV---SQSIGLAVGAALS- 692
            ..|:| ||::::.|.:|....|.|. .:|    :...||:::|...:|   :.|:.||:.|..|
Human   473 KLLSDLLPMRMLPSIIFTCIVYFMLGLKP----KADAFFVMMFTLMMVAYSASSMALAIAAGQSV 533

  Fly   693 LKLGSILGPFFICPFLQFSGFFLMEKDAPVFLRWMFDISFLKYSLEGATMAIF-GYDREP----- 751
            :.:.::|........:.|||..:.......:|.|:...|..:|.........| |.:..|
Human   534 VSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNAT 598

  Fly   752 --LACNELYCHLRHPQFILK-SLDMA-----NGNYTLA-LIFLFGVLVFLRIL 795
              ..||  |......::::| .:|::     ..:..|| :|.:|..:.:|::|
Human   599 GNNPCN--YATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLL 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	3a01204	149..808	CDD:273361	182/683 (27%)
ABCG2	NP_004818.2	3a01204	55..649	CDD:273361	174/660 (26%)