DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9663 and ABCG2

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_181272.1	Gene:	ABCG2 / 818312	AraportID:	AT2G37360	Length:	755	Species:	Arabidopsis thaliana

Alignment Length:	858	Identity:	197/858 - (22%)
Similarity:	341/858 - (39%)	Gaps:	216/858 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SGALPRPTTPVPSKKLSSKRPPHLTLNIKAKSHDAPLAETENTVLSTSESVYGTPLGATPVSSPA 106
            ||.|.:.:   |:|::..             ::|.|:             .|..|:...|...|:
plant     2 SGLLGKSS---PAKRVDG-------------NNDLPM-------------YYVNPMSVEPQGRPS 37

  Fly   107 NQSQRSQA-SQH--------SDESRNT-----SSTATSGGSIFPHEQYKTIKKIN-----IGFEN 152
            :.::.|.. ::|        :|||.::     :|...|..|.|..........|:     :.|.:
plant    38 DTTRVSVTFAEHLMNVEDARNDESASSRALGIASPINSAASSFNSWASAPASSISSSPFVLSFTD 102

  Fly   153 IRYTTKFGVFQRE-----------------TKDVLMGLTGYFKSGELSAVIGPSGAGKSTLLNIL 200
            :.|:.|   .|::                 ||.:|.|::|..:.||:.||:|.||:|||||::.|
plant   103 LTYSVK---IQKKFNPLACCRRSGNDSSVNTKILLNGISGEAREGEMMAVLGASGSGKSTLIDAL 164

  Fly   201 SG-YTTYGFTGDFRVNGNRRDLKAFKSNVAFIRQDTSLQAFLSVKEAMHFAANLKIGTHMTHSEK 264
            :. .......|...:||...:....|...|::.||..|...|:|:|.:.|:|..::...::..:|
plant   165 ANRIAKDSLRGSITLNGEVLESSMQKVISAYVMQDDLLFPMLTVEETLMFSAEFRLPRSLSKKKK 229

  Fly   265 RERVKCILEAIGMYENRHTRTGQ-----LSGGQKKRLAIALELVNNPPVLILDEPTTGLDSFTSN 324
            :.||:.:::.:|:.....|..|.     :|||:::|::|..:::::|.:|.|||||:||||.::.
plant   230 KARVQALIDQLGLRSAAKTVIGDEGHRGVSGGERRRVSIGNDIIHDPIILFLDEPTSGLDSTSAY 294

  Fly   325 QLINLLKKLAIEGRTVICTIHQPSALTFAMFDHLYAIGEGKCIYAGGAQNLLPFLGALNLHCPES 389
            .:|.:|:::|..|..||.:|||||.....:.|.|..:.:|..:|:|...:|..|........||:
plant   295 MVIKVLQRIAQSGSIVIMSIHQPSYRIMGLLDQLIFLSKGNTVYSGSPTHLPQFFSEFKHPIPEN 359

  Fly   390 YNPADYLMEIATHDYDTAEDNQLEKLVALMDNGRNEDYRQSKTARVAQLAAMKKVDQLMAAGLIT 454
            .|..::.:::.                      |..:|....|..:.:.....:..|
plant   360 ENKTEFALDLI----------------------RELEYSTEGTKPLVEFHKQWRAKQ-------- 394

  Fly   455 PVTAPVMSTSVPAHFMQGNTFKPLTPINELSSRVWDSQTAGIGNAGSCCKPKKKNKSRPAIELDP 519
                      .|::   .|..|..|.::.|...:    ||.| :.|........|.|
plant   395 ----------APSY---NNNNKRNTNVSSLKEAI----TASI-SRGKLVSGATNNNS-------- 433

  Fly   520 SHLCKRQNIYATPFYRQLSILLVRTFLLIWRDSSLTTMRFAIHLITGILIGTLYFGIGND---AA 581
            |:|......:|.||:.::.::..|..|...|...|..||....::|||::.|::..:.|.   |.
plant   434 SNLTPSFQTFANPFWIEMIVIGKRAILNSRRQPELLGMRLGAVMVTGIILATMFTNLDNSPKGAQ 498

  Fly   582 QTLNIFRY----LFYTIMFIMYCAFSGILVKFPLEFPIVSREHFNRWYSLRAYYVAITLADLPIQ 642
            :.|..|.:    .|||      ||.:  :..|..|..|..||.....|...:|.::.::..:|..
plant   499 ERLGFFAFAMSTTFYT------CAEA--IPVFLQERYIFMRETAYNAYRRSSYVLSQSIISIPAL 555

  Fly   643 IICSALFIVPTYLMTQQPLELWRFGM------FFLIVFVTALVSQSIGLAV-----GAALSLKLG 696
            |:.||.|...|:         |..|:      ||...| |.|.|...|.:.     |...::.||
plant   556 IVLSASFAATTF---------WAVGLDGGANGFFFFYF-TILASFWAGSSFVTFLSGVIPNVMLG 610

  Fly   697 SILGPFFICPFLQFSGFFLMEKDAPVFLRWMFDISFLKYSLEGATMAIFG------------YDR 749
            ..:....:..||.|||||:.....||:..|...||.:||..||.....|.            :|.
plant   611 FTVVVAILAYFLLFSGFFISRDRIPVYWLWFHYISLVKYPYEGVLQNEFQNPTRCFARGVQLFDN 675

  Fly   750 EPLA--CNELYCHLRHPQFILKSL---------------------------DMANGN---YTLAL 782
            .||.  .|::..:|      |||:                           |::..|   .|:|.
plant   676 SPLGEFPNDVKVNL------LKSMSGVLGTNVTAETCVTTGIDILKQQGITDISKWNCLWITVAW 734

  Fly   783 IFLFGVLVFLRIL 795
            .|.|.||.:..:|
plant   735 GFFFRVLFYFTLL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	73/252 (29%)
		3a01204	149..808	CDD:273361	176/732 (24%)
		ABC2_membrane	540..743	CDD:279410	60/220 (27%)
ABCG2	NP_181272.1	3a01204	95..754	CDD:273361	176/736 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820