DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9663 and Abcg8

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_080456.1	Gene:	Abcg8 / 67470	MGIID:	1914720	Length:	673	Species:	Mus musculus

Alignment Length:	764	Identity:	174/764 - (22%)
Similarity:	309/764 - (40%)	Gaps:	188/764 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 SQRSQASQHSDESRNTSSTATSGGS---------------------------IFPHEQYKTIKKI 146
            ||..|.|..|.||.|:.....||.|                           ..|...:.:....
Mouse    21 SQGLQDSLFSSESDNSLYFTYSGQSNTLEVRDLTYQVDIASQVPWFEQLAQFKIPWRSHSSQDSC 85

  Fly   147 NIGFENIRYTTKFGVFQRETKDVLMGLTGYFKSGELSAVIGPSGAGKSTLLNILSGYTTYG--FT 209
            .:|..|:.:..                    :||::.|:||.||.|:::||::::|....|  .:
Mouse    86 ELGIRNLSFKV--------------------RSGQMLAIIGSSGCGRASLLDVITGRGHGGKMKS 130

  Fly   210 GDFRVNGNRRDLKAFKSNVAFIRQDTSLQAFLSVKEAMHFAANLKIGTHMTHSEKRERVKCILEA 274
            |...:||.....:..:..||.:||...|...|:|:|.:.|.|.:::....:.:::.:||:.::..
Mouse   131 GQIWINGQPSTPQLVRKCVAHVRQHDQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAE 195

  Fly   275 IGMYENRHTRTGQ-----LSGGQKKRLAIALELVNNPPVLILDEPTTGLDSFTSNQLINLLKKLA 334
            :.:.:..:||.|.     :|||:::|::|.::|:.||.:|||||||:||||||::.|:..|.:||
Mouse   196 LRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVTTLSRLA 260

  Fly   335 IEGRTVICTIHQPSALTFAMFDHLYAIGEGKCIYAGGAQNLLPFLGALNLHCPESYNPADYLMEI 399
            ...|.|:.::|||.:..|.:||.:..:..|..||.|.||.::.:..::...||...||||:.:::
Mouse   261 KGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQQMVQYFTSIGHPCPRYSNPADFYVDL 325

  Fly   400 ATHDYDTAEDNQLEKLVALMDNGRNEDYRQSKTARVAQLAAMKKVDQLMAAGLITPVTAPVMSTS 464
            .:.|                        |:||...|   |.::|...|.|.
Mouse   326 TSID------------------------RRSKEREV---ATVEKAQSLAAL-------------- 349

  Fly   465 VPAHFMQGNTFKPLTPINELSSRVWDSQTAGIGNAGSCCKPKKKNKSRPAIELDPSHLCKRQNIY 529
                |::        .:......:|.::.            |:.|.|...:.|..:.........
Mouse   350 ----FLE--------KVQGFDDFLWKAEA------------KELNTSTHTVSLTLTQDTDCGTAV 390

  Fly   530 ATP-FYRQLSILLVRTFLLIWRDSSLTTMRFAIH----LITGILIGTLYFGIGNDAAQTLNIFRY 589
            ..| ...|.|.|:.|.....:||  |.|:  .||    .:..::||.||:|.|......::....
Mouse   391 ELPGMIEQFSTLIRRQISNDFRD--LPTL--LIHGSEACLMSLIIGFLYYGHGAKQLSFMDTAAL 451

  Fly   590 LFYTIMFIMYCAFSGILVKFPLEFPIVSREHFNR---WYSLR-------AYYVAITLADLPIQII 644
            ||          ..|.|:.|.:...:||:.|..|   :|.|.       .|:.|..|.:||....
Mouse   452 LF----------MIGALIPFNVILDVVSKCHSERSMLYYELEDGLYTAGPYFFAKILGELPEHCA 506

  Fly   645 CSALFIVPTYLMTQ-QPL-ELWRFGMFFLIVFVTALVSQSIGLAVGAAL-SLKLGSILGPFFIC- 705
            ...::.:|.|.:|. :|: ||  |.:.||:|::.....:::.||..|.| :..:.|     |.|
Mouse   507 YVIIYAMPIYWLTNLRPVPEL--FLLHFLLVWLVVFCCRTMALAASAMLPTFHMSS-----FFCN 564

  Fly   706 ----PFLQFSGFFLMEKDAPVFLRWMFDISFLKYSLEGATMAIFGYDREPLACNELYCHLRHPQF 766
                .|...:||.:...:..:...|:..:|||::...|.....|.            .||...|.
Mouse   565 ALYNSFYLTAGFMINLDNLWIVPAWISKLSFLRWCFSGLMQIQFN------------GHLYTTQI 617

  Fly   767 -----------ILKSLDMANGNYTLALIFLFGVLVFLRILAFYIMSFRL 804
                       ::.::|:  .::.|..|:|..:.:....|..|.:|.:|
Mouse   618 GNFTFSILGDTMISAMDL--NSHPLYAIYLIVIGISYGFLFLYYLSLKL 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	68/231 (29%)
		3a01204	149..808	CDD:273361	162/697 (23%)
		ABC2_membrane	540..743	CDD:279410	55/224 (25%)
Abcg8	NP_080456.1	ABCG_White	71..296	CDD:213201	69/244 (28%)
		3a01204	89..664	CDD:273361	160/694 (23%)
		ABC2_membrane	402..606	CDD:279410	55/224 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831355
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650