Protein Alignment CG9663 and ABCG5

DIOPT Version :10

• Sequence 1: NP_608760.2
• Gene: CG9663 / 33541
• FlyBaseID: FBgn0031516
• Length: 808
• Species: Drosophila melanogaster
• Sequence 2: NP_071881.1
• Gene: ABCG5 / 64240
• HGNCID: 13886
• Length: 651
• Species: Homo sapiens
• Alignment Length: 760
• Identity: 183/760 - (24%)
• Similarity: 309/760 - (40%)
• Gaps: 176/760 - (23%)

  Fly   100 TPVSSPANQSQRSQASQHSDESRNTSSTATSGGSIFPHEQYKTIKKINIGFENIRYTTKFGV--- 161
            ||..|...|..|  .||.|.|  ...:||..     ||         ::|..:..|:....|
Human     8 TPGGSMGLQVNR--GSQSSLE--GAPATAPE-----PH---------SLGILHASYSVSHRVRPW 54

  Fly   162 ------FQRETKDVLMGLTGYFKSGELSAVIGPSGAGKSTLLNILSGYTTYG--FTGDFRVNGNR 218
                  .|:.|:.:|..::.|.:||::..::|.||:||:|||:.:||.....  |.|:..|||..
Human    55 WDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRA 119

  Fly   219 RDLKAFKSNVAFIRQDTSLQAFLSVKEAMHFAANLKI--GTHMTHSEKRERVKCIL-------EA 274
            ...:.|:...:::.|..:|.:.|:|:|.:|:.|.|.|  |...:..:|.|.|...|       ..
Human   120 LRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRL 184

  Fly   275 IGMYENRHTRTGQLSGGQKKRLAIALELVNNPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRT 339
            ||.|.     .|.:|.|:::|::||.:|:.:|.|::.||||||||..|:||::.||.:||...|.
Human   185 IGNYS-----LGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRI 244

  Fly   340 VICTIHQPSALTFAMFDHLYAIGEGKCIYAGGAQNLLPFLGALNLHCPESYNPADYLMEIATHDY 404
            |:.|||||.:..|.:||.:..:..|:.|:.|....:|.|.......|||..||.|:.|::.:.|.
Human   245 VVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDT 309

  Fly   405 DTAE-DNQLEKLVALMDNGRNEDYRQS----KTARVAQLAAMKKVDQLMAAGLITPVTAPVMSTS 464
            .:.| :.:..|.|.::::.    |::|    ||.:  .:..||.:..|
Human   310 QSKEREIETSKRVQMIESA----YKKSAICHKTLK--NIERMKHLKTL----------------- 351

  Fly   465 VPAHFMQGNTFKPLTPINELSSRVWDSQTAGIGNAGSCCKPKKKNKSRPAIELDPSHLCKR--QN 527
                        |:.|.                          |.|..|.:......|.:|  :|
Human   352 ------------PMVPF--------------------------KTKDSPGVFSKLGVLLRRVTRN 378

  Fly   528 IYATP---FYRQLSILLVRTFLLIWRDSSLTTMRFAIHLITGILIGTLYFGIGNDAAQTLNIFRY 589
            :....   ..|.|..|::..|||.          |.:.:.:.:|.|.:...:|
Human   379 LVRNKLAVITRLLQNLIMGLFLLF----------FVLRVRSNVLKGAIQDRVG------------ 421

  Fly   590 LFYTIMFIMYCAFSGILVKFPLEFPI---VSREH-----FNRWYSLRAYYVAITLADLPIQIICS 646
            |.|  .|:....::|:|....| ||:   ||.:.     :.:|..:.||.:.:    ||..::.:
Human   422 LLY--QFVGATPYTGMLNAVNL-FPVLRAVSDQESQDGLYQKWQMMLAYALHV----LPFSVVAT 479

  Fly   647 ALFIVPTYLMTQQPLELWRFGMFFLIVFVTALVSQSIGLAVGAALSLKLGSILGP---------F 702
            .:|....|.......|:.|||.|...:....|:.:.:.|.:       ||.:..|         .
Human   480 MIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVL-------LGIVQNPNIVNSVVALL 537

  Fly   703 FICPFLQFSGFFLMEKDAPVFLRWMFDISFLKYSLEGATMAIF-------GYDREPLACNELYCH 760
            .|...|..|||....::.|:..:.:...:|.||..|...:..|       |.....:..|.:...
Human   538 SIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSNVSVTTNPMCAF 602

  Fly   761 LRHPQFILKSLDMANGNYTLALIFLFGVLVFLRILAFYIMSFRLR 805
            .:..|||.|:...|...:|:..:.|:..:..|.||.  |:.|::|
Human   603 TQGIQFIEKTCPGATSRFTMNFLILYSFIPALVILG--IVVFKIR 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	3a01204	149..808	CDD:273361	170/711 (24%)
ABCG5	NP_071881.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		9/27 (33%)
		ABCG_White	50..275	CDD:213201	76/229 (33%)
		3a01204	60..645	CDD:273361	166/688 (24%)