DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9663 and ABCG4

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001135977.1	Gene:	ABCG4 / 64137	HGNCID:	13884	Length:	646	Species:	Homo sapiens

Alignment Length:	784	Identity:	284/784 - (36%)
Similarity:	404/784 - (51%)	Gaps:	149/784 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SETHLPSRGSGTGSGALPRPTTPVPSKKLSSKRPPHLTLNIKAKSHDAPLAETENTVLSTSESVY 93
            :|..|.:.|.|.|.||:....|     ......||.||.::|         :.||.:
Human     2 AEKALEAVGCGLGPGAVAMAVT-----LEDGAEPPVLTTHLK---------KVENHI-------- 44

  Fly    94 GTPLGATPVSSPANQSQRSQASQHSDESRNTSSTATSGGSIFPHEQYKTIKKINIGFENIRYTTK 158
                         .::||                       |.|...::  .::|.|..:.|:.:
Human    45 -------------TEAQR-----------------------FSHLPKRS--AVDIEFVELSYSVR 71

  Fly   159 FGVFQRET--KDVLMGLTGYFKSGELSAVIGPSGAGKSTLLNILSGYTTYGFTGDFRVNGNRRDL 221
            .|...|:.  |.:|..|:|.|...||..::|||||||||.:|||:||...|..|...|||..|:|
Human    72 EGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPREL 136

  Fly   222 KAFKSNVAFIRQDTSLQAFLSVKEAMHFAANLKIGTHMTHSEKRERVKCILEAIGMYENRHTRTG 286
            :.|:....:|.||..|...|:|.|||..:||||:..  ....|:|.|..||.|:|:....||||.
Human   137 RTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSE--KQEVKKELVTEILTALGLMSCSHTRTA 199

  Fly   287 QLSGGQKKRLAIALELVNNPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICTIHQPSALT 351
            .|||||:|||||||||||||||:..||||:||||.:..|:::|:|.||..|||:|||||||||..
Human   200 LLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKL 264

  Fly   352 FAMFDHLYAIGEGKCIYAGGAQNLLPFLGALNLHCPESYNPADYLMEIATHDYDTAEDNQLEKLV 416
            |.|||.||.:.:|:||:.|...||:|:|..|.||||..:||||:::|:|:.:|  .:.|.:  |.
Human   265 FEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEY--GDLNPM--LF 325

  Fly   417 ALMDNGRNEDYRQSKTARVAQLAAM--KKVDQLMAAGLITPVTAPVMSTSVPAHFMQGNTFKPLT 479
            ..:.||               |.||  ||             ::| ....|||         |..
Human   326 RAVQNG---------------LCAMAEKK-------------SSP-EKNEVPA---------PCP 352

  Fly   480 PINELSSRVWDSQTAGIGNAGSCCKPKKKNKSRPAIELDP--SHLCKRQNIYATPFYRQLSILLV 542
            |                      |.|          |:||  ||      .:||....|..||..
Human   353 P----------------------CPP----------EVDPIESH------TFATSTLTQFCILFK 379

  Fly   543 RTFLLIWRDSSLTTMRFAIHLITGILIGTLYFGIGNDAAQTLNIFRYLFYTIMFIMYCAFSGILV 607
            ||||.|.||:.||.:||..|::.|:|||.||..||:||::..|....||::::|:|:.|....::
Human   380 RTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVL 444

  Fly   608 KFPLEFPIVSREHFNRWYSLRAYYVAITLADLPIQIICSALFIVPTYLMTQQPLELWRFGMFFLI 672
            .||||..:..|||.|.||||:|||:|.|:||:|.|::|..::....|.||.||.|..||.:|..:
Human   445 TFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSAL 509

  Fly   673 VFVTALVSQSIGLAVGAAL-SLKLGSILGPFFICPFLQFSGFFLMEKDAPVFLRWMFDISFLKYS 736
            ...||||:||:||.:|||. ||::.:.:||....|.|.|||||:..|..|.:|:|...:|:::|.
Human   510 ATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYG 574

  Fly   737 LEGATMAIFGYDREPLACNELYCHLRHPQFILKSLDMANGNYTLALIFLFGVLVFLRILAFYIMS 801
            .||..:.|:|.:|..|.|.|..|..|.||.||::||:.:....:..:.|....:.||:||:.::.
Human   575 FEGVILTIYGMERGDLTCLEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLR 639

  Fly   802 FRLR 805
            :|::
Human   640 YRVK 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	112/226 (50%)
		3a01204	149..808	CDD:273361	264/664 (40%)
		ABC2_membrane	540..743	CDD:279410	90/203 (44%)
ABCG4	NP_001135977.1	3a01204	44..646	CDD:273361	269/728 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141414
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750