DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9663 and abcg1

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001103924.1	Gene:	abcg1 / 556979	ZFINID:	ZDB-GENE-070424-84	Length:	673	Species:	Danio rerio

Alignment Length:	765	Identity:	277/765 - (36%)
Similarity:	410/765 - (53%)	Gaps:	117/765 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 TTPVPSKKLSSKRPPHLTLNIKAKSHDAPLAETENTVLSTSESVYGTPLGATPVSSPANQSQRSQ 113
            ||...|..:::..||.|.|:.:.      :..:.:.::|...|...|||....:....|....:|
Zfish    13 TTVTNSIIMNTNGPPDLMLDPRT------VCVSIDEMMSNHVSSQQTPLLHAHLKKVENNLTEAQ 71

  Fly   114 ASQHSDESRNTSSTATSGGSIFPHEQYKTIKKINIGFENIRYTTKFGVFQRET--KDVLMGLTGY 176
            ..                 |..|..     ..:||.|:::.|:...|.:.|:.  |.:|.|::|.
Zfish    72 RF-----------------SYLPRR-----PAVNIEFKDLSYSVPEGPWWRKKGYKTLLKGISGN 114

  Fly   177 FKSGELSAVIGPSGAGKSTLLNILSGYTTYGFTGDFRVNGNRRDLKAFKSNVAFIRQDTSLQAFL 241
            |..|.|.|::||||||||||:|||:||...|..|:..:||:.|||::|:....:|.||..|...|
Zfish   115 FTGGALVAIMGPSGAGKSTLMNILAGYRETGMKGEILINGHPRDLRSFRKVSCYIMQDDMLLPHL 179

  Fly   242 SVKEAMHFAANLKIGTHMTHSEK----RERVKCILEAIGMYENRHTRTGQLSGGQKKRLAIALEL 302
            :|:|||..:||||:      .||    ||.|:.||.|:|:.|...|||..|||||:|||||||||
Zfish   180 TVQEAMMVSANLKL------QEKDEGRREMVREILTALGLLECAKTRTSHLSGGQRKRLAIALEL 238

  Fly   303 VNNPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICTIHQPSALTFAMFDHLYAIGEGKCI 367
            ||||||:..||||:||||.:..|:::|:|.||..|||||||||||||..|.:||.||.:.:|:||
Zfish   239 VNNPPVMFFDEPTSGLDSSSCFQVVSLMKALAQGGRTVICTIHQPSAKVFELFDKLYVLSQGQCI 303

  Fly   368 YAGGAQNLLPFLGALNLHCPESYNPADYLMEIATHDYDTAEDNQLEKLV-ALMDNGRNEDYRQSK 431
            |.|...:|:|:|..|.|.||..:||||::||:|:.:|    .:|..:|| |:.::...:||:..
Zfish   304 YRGKVSSLIPYLRDLGLSCPTYHNPADFIMEVASGEY----GDQTARLVKAVQEHKCEKDYKTE- 363

  Fly   432 TARVAQLAAMKKVDQLMAAGLITPVTAPVMSTSVPAHFMQGNTFKPLTPINELSSRVWDSQTAGI 496
                                                  |.||                     |:
Zfish   364 --------------------------------------MNGN---------------------GV 369

  Fly   497 GNAGSCCKPKKKNKSRPAIELDPSHLCKRQNIYATPFYRQLSILLVRTFLLIWRDSSLTTMRFAI 561
            .|.....:|..:..|       .|..|   :.::.....|..||..||||.|.|||.||.:|...
Zfish   370 HNPFLWHRPSDEESS-------SSEGC---HSFSASCLTQFCILFKRTFLSIMRDSVLTHLRIMS 424

  Fly   562 HLITGILIGTLYFGIGNDAAQTLNIFRYLFYTIMFIMYCAFSGILVKFPLEFPIVSREHFNRWYS 626
            ||..|||||.||.||||:|.:.|:...:||::::|:|:.|....::.||||..:..|||.|.|||
Zfish   425 HLGIGILIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYS 489

  Fly   627 LRAYYVAITLADLPIQIICSALFIVPTYLMTQQPLELWRFGMFFLIVFVTALVSQSIGLAVGAA- 690
            |:|||:|.|:||:|.||:....:....|.||.||.:..||.:|..:..:|:||:||:||.:|||
Zfish   490 LKAYYLAKTMADVPFQIVFPVAYCSIVYWMTSQPSDAVRFILFLALGTLTSLVAQSLGLLIGAAS 554

  Fly   691 LSLKLGSILGPFFICPFLQFSGFFLMEKDAPVFLRWMFDISFLKYSLEGATMAIFGYDREPLACN 755
            .||::.:.:||....|.|.|||||:.....|.:|:|:..||:::|..||..::|:|.|||.|.|:
Zfish   555 TSLQVATFVGPVTAIPVLLFSGFFVSFDTIPKYLQWISYISYVRYGFEGVILSIYGLDREDLHCD 619

  Fly   756 -ELYCHLRHPQFILKSLDMANGNYTLALIFLFGVLVFLRILAFYIMSFRL 804
             :..||.:..:.|||.||:.:....:..|.|....:.||::|::::.:::
Zfish   620 KDETCHFQKSEAILKELDVEDAKLYMDFIVLGIFFISLRLIAYFVLRYKI 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	118/230 (51%)
		3a01204	149..808	CDD:273361	259/665 (39%)
		ABC2_membrane	540..743	CDD:279410	91/203 (45%)
abcg1	NP_001103924.1	3a01204	67..673	CDD:273361	264/705 (37%)
		ABCG_EPDR	81..306	CDD:213180	118/230 (51%)
		ABC2_membrane	403..605	CDD:279410	91/201 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574352
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.710