DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9663 and Abca6

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	XP_006247716.1	Gene:	Abca6 / 303639	RGDID:	1308998	Length:	1630	Species:	Rattus norvegicus

Alignment Length:	876	Identity:	187/876 - (21%)
Similarity:	296/876 - (33%)	Gaps:	259/876 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 PLGA----------TPVSSPANQSQRSQASQHSDESRNTSSTATSGGSIFPHE-QYKTIKKINIG 149
            |.||          .|||....::.|::.::     |:......|.....|.: :|:..:.|.|
  Rat   426 PCGADRRAAPLFFLNPVSCFRKRTSRNKVTE-----RDIDPELPSDEYFEPVDPEYQGKEAIRI- 484

  Fly   150 FENIR--YTTKFGVFQRETKDVLMGLTGYFKSGELSAVIGPSGAGKSTLLNILSGYT--TYGFTG 210
             .|||  |..|.|     ..:.|.||.......:::||:|..|||||:|||||:|.:  |.|...
  Rat   485 -RNIRKEYKGKSG-----KVEALKGLFFDVYESQITAVLGHGGAGKSSLLNILNGLSVPTSGLAT 543

  Fly   211 DFRVN-GNRRDLKAFKSNVAFIRQDTSLQAFLSVKEAMHFAANLKIGTHMTHSEKRERVKCILEA 274
            .:..| ...:|||..:..:....|.......|:|||.:...||:|   .:......:.|:.||..
  Rat   544 VYNKNLSEMQDLKEIRKMIGVCPQHNVQFDALTVKENLTLFANIK---GIVPQSVAQEVQQILSE 605

  Fly   275 IGMYENRHTRTGQLSGGQKKRLAIALELVNNPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRT 339
            :.|...:......||.|||::|...:.::.:|.:|:|||||.|||.|:..::...||:...:...
  Rat   606 LDMQTIQDELAEHLSEGQKRKLTFGVAILGDPRILLLDEPTAGLDPFSRQRVWGFLKERRADRVI 670

  Fly   340 VICTIHQPSALTFAMFDHLYAIGEGKCIYAGGAQNLLPFLGALNLHCPESYN---PADYLMEIAT 401
            :..|.....|...|....:.:.|..||.   |:...|.....|..|.....|   .::.|.....
  Rat   671 LFSTQFTDEADILADRKVILSNGALKCT---GSSVFLKRKWGLGYHLSLFMNETCDSEQLTSFIN 732

  Fly   402 HDYDTA--EDNQLEKLVALMDNGRNEDYRQSKTARVAQLAAMKKVDQLMAAGLITPVTAPVMST- 463
            |....|  :....||||..:.        ..||::..:.  ...:|:....||:....:  |||
  Rat   733 HHIPGAKLKAKTKEKLVYTLP--------LEKTSKFPEF--FSDLDKYSGQGLMNYEVS--MSTL 785

  Fly   464 -----------SVPAHFMQGNTFKPLTPINELSSRVWDSQTAGIGNAGSCCKP--KKKNKSRPAI 515
                       |....|.:|.|......:||:                ....|  .|..|:..|:
  Rat   786 NEVFMNLEGEPSTTQDFEKGETLTDSDSLNEM----------------EVAPPSLSKAQKTMSAM 834

  Fly   516 ELDPSHLCKRQNIYATPFYRQLSILLVRTFLLIWRDSSLTTMRFAIHLITGILIGT--------- 571
            .|....:|....:......|:....|  |||.:...|       .|.|||..:...
  Rat   835 SLWRMQVCAIARLRVLKLRRERKAFL--TFLPLLGIS-------LIPLITEYMANALIEVKTNWE 890

  Fly   572 ----LYF---------------GIGN------DAAQTL---------------NIFRYLFYTIMF 596
                |||               .|.|      |..|:|               |....|.|....
  Rat   891 FKTDLYFLSPGQLPQGLRTSLLVINNTESNIEDFVQSLKHQNIVLEVDDFENRNATESLSYNGAI 955

  Fly   597 IM------YCAFSGI-----LVKFPLEFPIVSR---------EHFNR------------WYSLRA 629
            |:      | .||.:     |..||:...::|.         :|...            |:.:..
  Rat   956 IVSGRQKDY-RFSAVCNTKRLHCFPILMNVISNGILRMLNHTQHIRLEEDVLSSGIVVVWFGILE 1019

  Fly   630 YYVAITLADLPIQIICSALFIVPTYLMT-------QQPLELWRFGMF------------------ 669
            ..::|      :.|:||   :.|...|:       :...:||..|::
  Rat  1020 ASLSI------LFIVCS---VSPHIAMSSISDFKKKADSQLWISGLYPSAYWCGQALVDITLLSG 1075

  Fly   670 -----FLIVFVTAL---------VSQSIGLAVGAALSL------------KLGSILGPFFICPFL 708
                 ::.::.|.|         |...:.||.|.|.||            |.....|.:.||.|:
  Rat  1076 ILLTGYITLYTTKLMHIYLTGEIVLSIVLLAFGCAASLVFLTYVISFVFGKKRKNSGLWSICFFI 1140

  Fly   709 QFSGFF---LME--KDAPVFLRWM----FDISFLKYSLEGATMAIFGYDREPLACNELYCHLRHP 764
            ..:..|   ||:  .:|.:....|    |.::.|...||   |..:.|.||          ....
  Rat  1141 VITIMFDTVLMDPFNEALLISAMMLVPSFSLNALLIVLE---MRAYQYYRE----------FGES 1192

  Fly   765 QFILKSLDMANGNYTLALIFLFGVLVFLRIL 795
            ::.|..:|:     .|.||..|..|:|:.:|
  Rat  1193 KYGLSGVDL-----LLCLIPYFHTLLFIFVL 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	68/229 (30%)
		3a01204	149..808	CDD:273361	174/812 (21%)
		ABC2_membrane	540..743	CDD:279410	62/343 (18%)
Abca6	XP_006247716.1	ABC2_membrane_3	35..420	CDD:289468
		ABC2_membrane_4	220..409	CDD:289500
		CcmA	480..795	CDD:224054	88/339 (26%)
		ABC_subfamily_A	482..705	CDD:213230	69/235 (29%)
		ABC2_membrane_3	859..1171	CDD:289468	59/330 (18%)
		ABC2_membrane_4	1007..1178	CDD:289500	31/179 (17%)
		CcmA	1279..1605	CDD:224054
		ABC_subfamily_A	1300..1514	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000