DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9663 and Abca5

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_775429.1	Gene:	Abca5 / 286970	RGDID:	628661	Length:	1642	Species:	Rattus norvegicus

Alignment Length:	710	Identity:	143/710 - (20%)
Similarity:	260/710 - (36%)	Gaps:	186/710 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 SQHSDESRNTS--STATSGGSIFPHEQYKTIKKINIGFENIRYTTKFGVFQR--ETKDVLMGLTG 175
            |..|...||..  |.....|:|..:|..:.:....||.|.||.:.....:::  ||.:.|..|:.
  Rat   438 SYWSKNKRNYKELSEGNINGNISLNEIVEPVSSEFIGKEAIRISGIQKAYRKKNETVEALRNLSF 502

  Fly   176 YFKSGELSAVIGPSGAGKSTLLNILSGY--TTYGFTGDFRVNGNR----RDLKAFKSNVAFIRQD 234
            ....|:::|::|.||.|||||:|||.|.  .:.||..   :.|:|    .::...:..:....|.
  Rat   503 DIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFAS---IYGHRVSEIDEMFEARKMIGICPQS 564

  Fly   235 TSLQAFLSVKEAMHFAANLKIGTHMTHSEKRERVKCILEAIGMYENRHTRTGQLSGGQKKRLAIA 299
            ......|:|:|.:...|::|   .:..:...:.|:.:|..:.|...:..:..:||||||::|::.
  Rat   565 DMNFDVLTVEENLSILASVK---GIPANNIIQEVQKVLLDLDMQAIKDNQAKKLSGGQKRKLSLG 626

  Fly   300 LELVNNPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICTIHQPSALTFAMFDHLYAIGEG 364
            :.::.||.:|:|||||.|:|..:.:.:.||||.......||..|.....|...|  |....|.:|
  Rat   627 IAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILA--DRKAVISQG 689

  Fly   365 --KCIYAG---------------------GAQNL------------------------LPF---- 378
              ||:.:.                     ..::|                        |||
  Rat   690 MLKCVGSSIFLKSKWGIGYRLSMYIDRYCATESLSSLVRQHIPAAALLQQNDQQIVYSLPFKDMD 754

  Fly   379 -----LGALNLH-----------------------CPESYNPADYLM--------EIATHDYDTA 407
                 ..||::|                       .....:.|||.:        |..:..:|..
  Rat   755 KFSGLFSALDIHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPREEETDSKSFDEM 819

  Fly   408 EDNQL------EKLVALMDNGRNEDYRQSKTARVAQLAAMKKVDQLMAAGLITPVTAPVMSTSVP 466
            |.:.|      ..||:.|...:.:   .|..|:...|:..::...:.:..|:..:...|......
  Rat   820 EQSLLILSETKASLVSTMSLWKQQ---VSTIAKFHFLSLKRESKSVRSVLLLLLIFFAVQIFMFL 881

  Fly   467 AHFMQGNTFKPLTPINELSSRVWDSQTAGIGNAGSCCKP-KKKNKSRPAIELDPS---------H 521
            .|....|...|:..:.:|                ...|| .|.:|.:.::.|..|         .
  Rat   882 VHHSFKNAVVPIKLVPDL----------------YFLKPGDKPHKYKTSLLLQNSTDSDINDLID 930

  Fly   522 LCKRQNIY-----------ATPFYRQLSILLVR---TFLLIWRDSSLTTMRFAIHLITGILIGTL 572
            ...:|||.           |.|....|:::...   .|..::.    :||.:::.::..|:  :.
  Rat   931 FFTQQNIIVAMFNDSDYVSAAPHSAALNVVQSEKDYVFTAVFN----STMVYSLPVMMNII--SN 989

  Fly   573 YFGIGNDAAQTLNIFRYLF--------YTIMFIMYCAFSGILV-KFPLEFPIVSRE-HFNRWYSL 627
            |:....:...|:.|:...|        :.:......|..||:| ..|..|.:.:.| |..:.|:.
  Rat   990 YYLYHLNVTDTIQIWSTPFIQEITDIVFKVELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQ 1054

  Fly   628 --------RAYYVAITLADLPIQIICSALFIVPTYLMTQQPLELWRFGMFFLIVFVTALV 679
                    .||::...:.|:|:      .|:|.|.::..  |..:..|::|..|...|:|
  Rat  1055 LKLSGLLPSAYWIGQAVVDIPL------FFVVLTLMLGS--LFAFHHGLYFYPVKFLAVV 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	67/234 (29%)
		3a01204	149..808	CDD:273361	134/674 (20%)
		ABC2_membrane	540..743	CDD:279410	30/161 (19%)
Abca5	NP_775429.1	ABC2_membrane_3	<214..416	CDD:289468
		CcmA	476..788	CDD:224054	72/319 (23%)
		ABC_subfamily_A	478..701	CDD:213230	64/230 (28%)
		ABC2_membrane_3	<957..1224	CDD:289468	31/164 (19%)
		CcmA	1288..1615	CDD:224054
		ABC_subfamily_A	1290..1521	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000