DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9663 and Abcg3

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	XP_017176394.1	Gene:	Abcg3 / 27405	MGIID:	1351624	Length:	683	Species:	Mus musculus

Alignment Length:	769	Identity:	181/769 - (23%)
Similarity:	316/769 - (41%)	Gaps:	162/769 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSWSLASAVSPNVTGGDVIRLNHLKSSSETHLPSRGSGTGSGALPRPTTPV--PSKKLS----- 58
            ||..:|.||..|..:..    |....:....|   |||.:.:...|.|..|.  ||.|.|
Mouse     1 MSRPTLPSAPLPATSSA----LFGFPAPDHDH---RGSKSSAEQKPEPLAPSKDPSCKSSCASSN 58

  Fly    59 ---------SKRPPHLTLNIKAKSHDAPLAETENTVLSTSESVYGTPLGATPVSSPANQSQRSQA 114
                     .|.||.:..|            .:.||:|..|
Mouse    59 LSPCIISQWKKEPPEMASN------------NDPTVISMIE------------------------ 87

  Fly   115 SQHSDESRNTSSTATSGGSIFPHEQYKTI-KKINIGFENIRY--TTKFGVFQRETKDV---LMGL 173
             :|..:...|:::           ..||: ::..:.|.||.|  |.:.|...|:...|   |..:
Mouse    88 -RHLCDLPETNTS-----------DLKTLTEEAVLSFHNISYQETVQSGFPLRKKAYVIERLSNI 140

  Fly   174 TGYFKSGELSAVIGPSGAGKSTLLNILSG-YTTYGFTGDFRVNGNRRDLKAFKSNVAFIRQDTSL 237
            :|..|.| |:|::||....:|.||::|:. ....|.:||..:||..|... ||....::.|:..:
Mouse   141 SGIMKPG-LNAIMGPQDGSRSLLLDVLAARRDPRGLSGDILINGKPRPAN-FKCTSGYVPQNDVV 203

  Fly   238 QAFLSVKEAMHFAANLKIGTHMTHSEKRERVKCILEAIGM--YENRHTRTGQLSGGQKKRLAIAL 300
            ...::|::.:.|:|.|::...:|..|||.|:..:||.:.:  .:|...|:.:|    :||.:||:
Mouse   204 LGTVTVRDNLEFSAALRLPVTITRDEKRRRINEVLELLHLNKEQNIKPRSKEL----RKRTSIAM 264

  Fly   301 ELVNNPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICTIHQPSALTFAMFDHLYAIGEGK 365
            |||...|:|.||:||||||..|:..:|.:|::::.:|||:|.:|:||....|..||.|..:..||
Mouse   265 ELVTEHPILFLDDPTTGLDLRTTTDVILVLRRMSKKGRTIIFSINQPQYSIFKFFDSLTLVASGK 329

  Fly   366 CIYAGGAQNLLPFLGALNLHCPESYNPADYLMEIATHDY----DTAEDNQLEKLVALMDNGRNED 426
            .::.|.||:.|.:..:...:.....||||:.:::....:    ||.||            |..:|
Mouse   330 VMFHGPAQDALEYFRSAGYNYESHNNPADFFLDVINGGFSNILDTEED------------GHEDD 382

  Fly   427 YRQSKTARVAQLAAMKKVDQLMAAGLITPVTAPVMSTSVPAHFMQGNTFKPLTPINELSSRVWDS 491
            ..:....|..|:..  |:..:.|...:...|..::                             .
Mouse   383 KYEELFERQYQVTG--KLANMYAQSPLYSETRAIL-----------------------------D 416

  Fly   492 QTAGIGNAGSCCKPKKKNKSRPAIELDPSHLCKRQNIYATPFYRQLSILLVRTFLLIWRDSSLTT 556
            |..|          ::|.:...|:|.    .|      .|||..||..::.::|........:|.
Mouse   417 QLLG----------EQKLERSSAVET----TC------VTPFCHQLKWIICQSFKNFKGFPWVTV 461

  Fly   557 MRFAIHLITGILIGTLYFGIGNDAAQTLNIFRYLFYTIMFIMYCAFS---GILVKFPLEFPIVSR 618
            ::..|.:|....:||.:..:.||..: :.:...|.| ::.|..|..|   |.|  |.::......
Mouse   462 IQAIITVILATAVGTAFRVLKNDCIE-VQMRAGLLY-LLTIFQCITSVSAGEL--FVIDRVRFLH 522

  Fly   619 EHFNRWYSLRAYYVAITLADL-PIQIICSALFIVPTYLMTQQPLELWRFGMFFLIVFVTALVSQS 682
            ||.:.:|.:.:|:....||:| |.:::.|.:|.:.||::....:.:..|......:.|.|..:.|
Mouse   523 EHTSGYYRVSSYFFGKLLAELIPRRLLPSTVFSLITYVIAGVKMSMKCFFTMICTIMVLAYSASS 587

  Fly   683 IGLAVGAA-LSLKLGSILGPFFICPFLQFSGFFLMEKDAPVFLRWMFDISFLKY 735
            :.|::||. .::.:.::|...:....|.|||..|........|.|:...|...|
Mouse   588 LPLSIGAGENAVAVPTLLVTIYFVFMLFFSGLSLYSGSFLPKLSWIQYFSIPHY 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	76/232 (33%)
		3a01204	149..808	CDD:273361	151/604 (25%)
		ABC2_membrane	540..743	CDD:279410	45/201 (22%)
Abcg3	XP_017176394.1	3a01204	137..670	CDD:273361	143/578 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.800