DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9663 and wht-5

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_502352.1	Gene:	wht-5 / 178182	WormBaseID:	WBGene00008950	Length:	695	Species:	Caenorhabditis elegans

Alignment Length:	798	Identity:	210/798 - (26%)
Similarity:	342/798 - (42%)	Gaps:	170/798 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 AKSHDA-PLAETEN--------------TVLSTSESVYGTP----LGATPVSSPANQSQRSQASQ 116
            :||.:| ||.:.:|              |..|.|.:...||    :..|||:|...|.::..|
Worm     3 SKSEEAEPLLKPKNVEDEGLITSLDVDPTQKSRSPTPKPTPIPVLINDTPVASEIEQVEKELA-- 65

  Fly   117 HSDE----SRNTSSTATSGGSIFPHEQYKTIKKINIGFENIRYTT--KFGVFQRETKDVLMGLTG 175
            ||.|    .:..|.|..:..:..| .|.||..| .:.|:||:...  |.||.|    ::|..:.|
Worm    66 HSSERFRKPKTLSVTNDTESARIP-SQVKTNAK-KLVFQNIQAVVLKKKGVRQ----EILKKIDG 124

  Fly   176 YFKSGELSAVIGPSGAGKSTLLNILSGYTTYGF--TGDFRVNGNRRDLKAFKSNVAFIRQDTSLQ 238
            ..:.|||:.::|.|||||:||||||:|......  .||..:||........|...|:::||....
Worm   125 VARPGELTFIMGSSGAGKTTLLNILTGRNLKNIETDGDIMINGRNMISNEMKKLSAYVQQDDVFI 189

  Fly   239 AFLSVKEAMHFAANLKIGTHMTHSEKRERVKCILEAIGMYENRHTRTG-----QLSGGQKKRLAI 298
            ..|:|:|.:.|||.|:..:.:..:|....|..:|..:.:.:..:|:.|     .||.|::||||.
Worm   190 GTLTVRETLRFAAKLRSPSALGATELDSIVDELLVMMSLKKCENTKVGTMTEKSLSRGERKRLAF 254

  Fly   299 ALELVNNPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICTIHQPSALTFAMFDHLYAIGE 363
            |.|::.:||:|..||||:|||||.|:|:|..|::|.|||:||||||||||...:.|.|.|..:.:
Worm   255 ACEILTDPPILFCDEPTSGLDSFMSHQVIKALRQLTIEGKTVICTIHQPSTSVYHMADQLILLSQ 319

  Fly   364 GKCIYAGGAQNLLPFLGALNLHCPESYNPADYLMEIATH-DYDTAED--NQLEKLVALMDNGRNE 425
            |...|||.|:.:..|.|......|:..:..|:.|.:.:| .::|.:|  .::||:|.      ..
Worm   320 GHVAYAGPAKQVDAFFGRCGYPIPKFVSSPDHFMRVISHKSFETEDDYNKRIEKIVL------EH 378

  Fly   426 DYRQSKTARVAQLAAMKKVDQLMAAGLITPVTAPVMSTSVPAHFMQGNTFKPLTPINELSSRVWD 490
            |..:.:.:..:.|::.::..         |.|||.             ||          .|.|.
Worm   379 DIMKKEQSTHSTLSSSRREH---------PETAPF-------------TF----------PRTWT 411

  Fly   491 SQTAGIGNAGSCCKPKKKNKSRPAIELDPSHLCKRQNIYATPFYRQLSILLVRTFLLIWRDSSLT 555
            :|                                        |:    .:..|:.:.:||:.|:.
Worm   412 AQ----------------------------------------FF----FIFQRSSIQLWRERSVL 432

  Fly   556 TMRFAIHLITGILIGTLYFGIGNDAAQTLNIFRYLFYTIMFIMYCAFSGILVKFPLEFPIVSREH 620
            .::....||..|:||:.|:|:..|.....:...:.|.::..:........:..|..::|:|.||.
Worm   433 LVKLIQTLIMSIMIGSTYYGLEIDKKSLPSFKGFAFVSVQMMHMLFMMPAMTVFWKDYPVVVREF 497

  Fly   621 FNRWYSLRAYYVAITLAD----LPIQIICSALFIVPTYLMTQQPLELWRFGMFFLIVFVTALVSQ 681
            ....||..|||:|.|.||    |...:|.|.:.:.    ||..|..:.....:.:|..:.:|.:.
Worm   498 QANMYSPSAYYLAKTTADSIQYLVFPVIFSGILLG----MTSLPYSVVIITNYLIINILLSLNAC 558

  Fly   682 SIGLAVGAALS-LKLGSILGPFFICPFLQFSGFFLMEKDAPVFLRWMF----DISFLKYSLEGAT 741
            |:|.:..|... |..|..:.|....|.:.|.||.:..:..|    |.|    .:|:.||..|..|
Worm   559 SVGQSFAAMCGHLATGMTVLPIVCVPLMVFGGFMITYEAIP----WYFLPFAWVSWYKYGFEAIT 619

  Fly   742 MAIFGYDREPLAC--NELYCHLRHPQFILKSLDMANGNYTLALIF-----------------LFG 787
            :..|.::.....|  |.....|:      .|:|   .|.|..:.|                 :..
Worm   620 IVYFNHNSTISGCESNSSVATLK------MSID---SNCTTGIEFIKAQAFEETHLWLDYTVILA 675

  Fly   788 VLVFLRILAFYIMSFRLR 805
            |::|.:||...:.::|:|
Worm   676 VILFWKILGALLFTWRIR 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	90/233 (39%)
		3a01204	149..808	CDD:273361	183/697 (26%)
		ABC2_membrane	540..743	CDD:279410	53/211 (25%)
wht-5	NP_502352.1	3a01204	88..695	CDD:273361	188/711 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720