DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9663 and wht-3

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_497825.2	Gene:	wht-3 / 175528	WormBaseID:	WBGene00007631	Length:	614	Species:	Caenorhabditis elegans

Alignment Length:	722	Identity:	175/722 - (24%)
Similarity:	302/722 - (41%)	Gaps:	161/722 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 ESRNTSSTATSGGSIFPHEQYKTIKKINIGFENIRYTTKFGVFQRETKDVLMGLTGYFKSGELSA 184
            ||.:|||...:          :.:..|.:.:|||...|:..:|.::.|.:|..::|..|.||:.|
Worm    21 ESIDTSSQKLT----------EVVTPITVTWENIEVKTRKKLFSKKQKQLLNRVSGIAKPGEMVA 75

  Fly   185 VIGPSGAGKSTLLNILSGYTTYGF--TGDFRVNGNR--RDLKAFKSNVAFIRQDTSLQAFLSVKE 245
            ::|.|||||:||:|:|......|.  .|..:|||.:  :::....   .|.:|.......|:|.|
Worm    76 LMGASGAGKTTLMNVLMCRNMKGLEKNGTVKVNGTKIGKEISLIS---GFAQQQEIFIPTLTVDE 137

  Fly   246 AMHFAANLKIGTHMTHSEKRERVKCILEAIGMYENRHTRTGQ------LSGGQKKRLAIALELVN 304
            .:...|.|::..: .|: :||||..|:|.:.:...|..:.|.      :|||:.:||..|.||::
Worm   138 YLMIQARLRMKAN-KHT-RRERVDEIIEMLRLQNCRDLKIGTPGLVKGISGGEARRLTFACELLS 200

  Fly   305 NPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICTIHQPSALTFAMFDHLYAIGEGKCIYA 369
            ||.:|..||||:|||||.:..::.:||.||..|||:   ||||:|..|..||.:..:..||..:.
Worm   201 NPSLLFADEPTSGLDSFMAASVVQILKNLANSGRTL---IHQPTAELFFQFDKIIFLSMGKTAFM 262

  Fly   370 GGAQNLLPFLGALNLHCPESYNPADYL---MEIATHDYDTAEDNQLEKLVALMDNGRNEDYRQSK 431
            |.....:.|........|:.:||.:::   :.:..:: :|.....:.|::        |.|.:|
Worm   263 GTPHESVKFFADCGHPIPKLFNPPEWIQSKLSVIPNN-ETKSRETIGKII--------EFYEKS- 317

  Fly   432 TARVAQLAAMKKVDQLMAAGLITPVTAPVMSTSVPAHFMQGNTFKPLTPINELSSRVWDSQTAGI 496
                  :...|.:.::..          :.:|.:|.:                           |
Worm   318 ------IIHQKSIVEIRV----------IATTELPPY---------------------------I 339

  Fly   497 GNAGSCCKPKKKNKSRPAIELDPSHLCKRQNIYATPFYRQLSILLVRTFLLIWRDSSLTTMRFAI 561
            .|.|                                |:.:...||.|..|.:.|..:...|:...
Worm   340 ENPG--------------------------------FFAETGALLKRACLDVIRSPAQMRMKLIQ 372

  Fly   562 HLITGILIGTLYFGIGNDAAQTLNIFRYLFYTIMFIMYCAFSGILVKFPLEFPIVSREHFNRWYS 626
            .::.|:.||:||:....|.....|....|::.|..:.:....||:.....|.|:::||:.:..:.
Worm   373 KVVMGLFIGSLYWQQPLDPRGVRNTNSALYFLIAELTFSTMFGIMTFMEHELPLIAREYHDGLFY 437

  Fly   627 LRAYYVAITLADLPIQIICSALFIVPTYLMTQQPLELWRFGM------FFLIVFVTALVSQSIGL 685
            :.:||::..|:.||:..|..||.||.:|         |..|:      ....:.::.||.||
Worm   438 VISYYISRFLSYLPLFTIDGALMIVISY---------WMIGLNSTWQQVAKSILISVLVEQS--- 490

  Fly   686 AVGAALSLKL---GSILGPFFICP----FLQFSGFFLMEKDAPVFLRWMFDISFLKYSLEGATMA 743
            |....|.|..   .:.|...|..|    |...||.:....:.||::|||...|:.:|..||
Worm   491 ATSCGLFLACLFETTSLAIAFAVPASGLFALLSGLYGNTNNFPVYIRWMQWTSWCRYGFEG---- 551

  Fly   744 IFGYDREPLACNELYCHLRHP-------QFILKSLDMANGNYTLALIFLFGVLVFLRILAFYIMS 801
                    |..|: :..:.:|       :.|||.......||.|.:|.|..:::|..:..:..:.
Worm   552 --------LVVNQ-WSQVDNPKWDPFYRELILKQFSFNKDNYQLDVIGLCSIVIFFYLAGYIALF 607

  Fly   802 FRLRLFR 808
            .|:||.|
Worm   608 IRIRLSR 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	81/234 (35%)
		3a01204	149..808	CDD:273361	168/691 (24%)
		ABC2_membrane	540..743	CDD:279410	56/215 (26%)
wht-3	NP_497825.2	ABCG_EPDR	36..263	CDD:213180	81/234 (35%)
		3a01204	37..614	CDD:273361	169/694 (24%)
		ABC2_membrane	351..555	CDD:279410	57/227 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720