DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9663 and abt-2

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_490949.3	Gene:	abt-2 / 171782	WormBaseID:	WBGene00000020	Length:	2146	Species:	Caenorhabditis elegans

Alignment Length:	896	Identity:	172/896 - (19%)
Similarity:	286/896 - (31%)	Gaps:	353/896 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 VFQRETKDV-LMGLTGYFKSGELSAVIGPSGAGKSTLLNILSG-YTTYGFTGDFRVNGNRRDLKA 223
            |::..||.: .:.|..|  .|:::.::|.:||||:|.::||.| |.....|........|.||:.
Worm   937 VYENGTKALDCLNLRLY--EGQITGLLGHNGAGKTTTMSILCGLYAPSSGTAKIYQRDIRTDLRR 999

  Fly   224 FKSNVAFIRQDTSLQAFLSVKEAMHFAANLKIGTHMTHSEKRERVKCILEAIGMYENRHTRTGQL 288
            .:..:....|...|.:.|:|.|.:...|.||   .:..||...:|..||.::.:.|..:.....|
Worm  1000 VRDVLGICPQHNVLFSHLTVSEQLRLFAALK---GVPDSELTSQVDEILASVSLTEKANKLASTL 1061

  Fly   289 SGGQKKRLAIALELVNNPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICTIH-------- 345
            |||.|:||.|.:..:.....:||||||.|:|......:..||::.. ||||::.:.|
Worm  1062 SGGMKRRLCIGIAFIGGSRFVILDEPTAGVDVTARKDIWKLLQRNK-EGRTILLSTHHMDEADVL 1125

  Fly   346 ------------QPSAL--TFAMFDHLYAIGEGKCIYAGGA------QNLLP-FLGALNLHCPES 389
                        :|..|  ...:|.|.||:...:..|...:      |.::| ||.||    .|.
Worm  1126 SDRIAILSQDFEKPDLLDGKRLIFQHFYALLVCRINYTLKSKRTFLFQVIIPLFLLAL----AEL 1186

  Fly   390 YNPADYLMEIAT---------------------------HDYDTAEDNQLEKLV----------- 416
            :    .|::::|                           :.:||||::....::
Worm  1187 F----VLLQVSTARPDLMVSMPPLPLETSIMGNHSDFYVNSWDTAENSTANDILHAMFSSPGTGP 1247

  Fly   417 --------ALMDN-------------GRN------------------------------------ 424
                    .|:|.             |||
Worm  1248 RCAKDVPNDLLDTMRRELMFRNRYGFGRNKPAPGVDKDSVDNEYQCQNIQGEFDYTEDISNATYN 1312

  Fly   425 ----------------EDYRQSKT-------------------------ARVAQLA--------- 439
                            ||::.::|                         .|.||||
Worm  1313 APIYCGCEDFGWNCTLEDWKWNETNWLRLNTTDRIFDLTGRNLTQFRLITRFAQLANTTAPFFLG 1377

  Fly   440 --------------------------AMKKVDQLM------AAGLITPVTAPVMSTSVPAHFMQG 472
                                      .:|.:.|.|      ..| |.|.|..|:..     |.|.
Worm  1378 GFSLGHVNQRAQSQADIDTSKRGWLETIKDIAQSMRIINLNTTG-IEPATPKVLDP-----FAQN 1436

  Fly   473 NTFKPLTPINEL--------------SSRVW----------------------DSQTAGIGNAGS 501
            .|...:  :|:|              ::::|                      |.:..||....
Worm  1437 ITLNQV--VNDLLQNLDVRENVKVWFNNKIWPGFPIASNILSNALLRQEDYAIDPEDLGILTMN- 1498

  Fly   502 CCKPKKKNKSRPAIELDPSHLCKRQNIYATPFYRQLSILLVRTFLLIWRDSSLTTMRFAIHLITG 566
              .|..|..|:   .||       ||  |..|.:.|::..:...||:   .|:....|.::|:..
Worm  1499 --HPMNKTISQ---TLD-------QN--ALKFTQALAVFRITILLLV---LSMIPAGFTVYLVED 1546

  Fly   567 ILIGTLYFG-IGNDAAQTLNIFRYLF----YT-----IMFIMYC-----------AFSGILVKFP 610
            .:...|:.. :|.....|..:..||:    ||     ||.|..|           .|...|:.|.
Worm  1547 RICEALHLQLVGGLRKVTYWVTSYLYDMVVYTLVIIVIMLIYLCFRVSDFTADGATFFAFLLLFF 1611

  Fly   611 LE--FPIVSREHFNRWYSLRAY-YVAITLADLPIQIICSALFIVPTYLMTQQPLELWRFGMFFLI 672
            :.  ..|:....|.:.:|:.|. :|.|.:....:.|:|:...|:...||.|.| .|........|
Worm  1612 VHGMSTILYAYVFQKAFSVAALSFVLIAIGSYFVGIVCALTVIMLESLMVQDP-SLIPAHTVCSI 1675

  Fly   673 VFVTALVSQSIGLAVGAALSLKLGSILGPFFICPFLQFSGFFLMEKDAPVFLRWMFDISFLKYSL 737
            ||: .|...::|:|:...|.:.....:|           ..||.:.:.|..:..:...|.|.:..
Worm  1676 VFL-VLPQYNLGIAIFRGLMIYQVRAIG-----------SNFLQQMNRPDMINQLPLPSLLAFDQ 1728

  Fly   738 EG------------ATMAI-------FGYD-------------REPLACNE 756
            .|            ||:.:       ||:.             |||..|::
Worm  1729 MGIHIMCLFIHVIIATICLIFSQMDEFGFVRKRERNLTDAMMLREPSTCDD 1779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	64/232 (28%)
		3a01204	149..808	CDD:273361	172/896 (19%)
		ABC2_membrane	540..743	CDD:279410	49/238 (21%)
abt-2	NP_490949.3	rim_protein	39..2117	CDD:130324	172/896 (19%)
		ABC_subfamily_A	929..1134	CDD:213230	57/202 (28%)
		ABC_subfamily_A	1802..2024	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000