DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9663 and Abcg8

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_569098.2	Gene:	Abcg8 / 155192	RGDID:	620300	Length:	672	Species:	Rattus norvegicus

Alignment Length:	757	Identity:	170/757 - (22%)
Similarity:	320/757 - (42%)	Gaps:	184/757 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 QASQHSDESRNTSSTATSGGSIFPHEQYKTIKKINIGFE-----NIRYTTKFGVFQ-----RETK 167
            |.|..|.||.|:.....||       |..|::..::.::     .:.:..:...|:     |.::
  Rat    24 QDSVFSSESDNSLYFTYSG-------QSNTLEVRDLTYQVDMASQVPWFEQLAQFKLPWRSRGSQ 81

  Fly   168 DV----LMGLTGYFKSGELSAVIGPSGAGKSTLLNILSGYTTYG--FTGDFRVNGNRRDLKAFKS 226
            |.    :..|:...:||::.|:||.:|.|::|||::::|....|  .:|...:||.....:..:.
  Rat    82 DSWDLGIRNLSFKVRSGQMLAIIGSAGCGRATLLDVITGRDHGGKMKSGQIWINGQPSTPQLIQK 146

  Fly   227 NVAFIRQDTSLQAFLSVKEAMHFAANLKIGTHMTHSEKRERVKCILEAIGMYENRHTRTGQ---- 287
            .||.:||...|...|:|:|.:.|.|.:::....:.:::.:||:.::..:.:.:..:||.|.
  Rat   147 CVAHVRQQDQLLPNLTVRETLTFIAQMRLPKTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVR 211

  Fly   288 -LSGGQKKRLAIALELVNNPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICTIHQPSALT 351
             :|||:::|::|.::|:.||.:|||||||:||||||::.|:..|.:||...|.|:.::|||.:..
  Rat   212 GVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVRTLSRLAKGNRLVLISLHQPRSDI 276

  Fly   352 FAMFDHLYAIGEGKCIYAGGAQNLLPFLGALNLHCPESYNPADYLMEIATHDYDTAEDNQLEKLV 416
            |.:||.:..:..|..||.|.||:::.:..::...||...||||:.:::.:.|
  Rat   277 FRLFDLVLLMTSGTPIYLGVAQHMVQYFTSIGYPCPRYSNPADFYVDLTSID------------- 328

  Fly   417 ALMDNGRNEDYRQSKTARVAQLAAMKKVDQLMAAGLITPVTAPVMSTSVPAHFMQGNTFKPLTPI 481
                       |:||...|   |.|:|. :|:||..:..|              ||
  Rat   329 -----------RRSKEQEV---ATMEKA-RLLAALFLEKV--------------QG--------- 355

  Fly   482 NELSSRVWDSQTAGIG--------------NAGSCCKPKKKNKSRPAIELDPSHLCKRQNIYATP 532
              ....:|.::...:.              |.|:            |.|| |..:
  Rat   356 --FDDFLWKAEAKSLDTGTYAVSQTLTQDTNCGT------------AAEL-PGMI---------- 395

  Fly   533 FYRQLSILLVRTFLLIWRDSSLTTMRFAIHLITGILIGTLYFGIGNDAAQTLNIFRYLFYTIMFI 597
              :|.:.|:.|.....:||.....:..|...:..::||.||:|..:.....:::...||
  Rat   396 --QQFTTLIRRQISNDFRDLPTLFIHGAEACLMSLIIGFLYYGHADKPLSFMDMAALLF------ 452

  Fly   598 MYCAFSGILVKFPLEFPIVSREHFNR---WYSLR-------AYYVAITLADLPIQIICSALFIVP 652
                ..|.|:.|.:...:||:.|..|   :|.|.       .|:.|..|.:||.......::.:|
  Rat   453 ----MIGALIPFNVILDVVSKCHSERSLLYYELEDGLYTAGPYFFAKVLGELPEHCAYVIIYGMP 513

  Fly   653 TYLMTQ-QP---LELWRFGMFFLIVFVTALVSQSIGLAVGAAL------SLKLGSILGPFFICPF 707
            .|.:|. :|   |.|..|.:.:|:||    ..:::.||..|.|      |....::...|::.
  Rat   514 IYWLTNLRPGPELFLLHFMLLWLVVF----CCRTMALAASAMLPTFHMSSFCCNALYNSFYLT-- 572

  Fly   708 LQFSGFFLMEKDAPVFLRWMFDISFLKYSLEGATMAIFGYDREPLACNELYCHLRHPQF------ 766
               :||.:...:..:...|:..:|||::...|.....|.            .|:...|.
  Rat   573 ---AGFMINLNNLWIVPAWISKMSFLRWCFSGLMQIQFN------------GHIYTTQIGNLTFS 622

  Fly   767 -----ILKSLDMANGNYTLALIFLFGVLVFLRILAFYIMSFR 803
                 ::.::|:  .::.|..|:|..:.:....|:.|.:|.:
  Rat   623 VPGDAMVTAMDL--NSHPLYAIYLIVIGISCGFLSLYYLSLK 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	70/245 (29%)
		3a01204	149..808	CDD:273361	160/721 (22%)
		ABC2_membrane	540..743	CDD:279410	49/222 (22%)
Abcg8	NP_569098.2	ABCG_White	60..295	CDD:213201	70/234 (30%)
		3a01204	88..662	CDD:273361	157/684 (23%)
		ABC2_membrane	401..605	CDD:279410	49/222 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750