DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9663 and Abcg5

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_446206.2	Gene:	Abcg5 / 114628	RGDID:	620298	Length:	652	Species:	Rattus norvegicus

Alignment Length:	777	Identity:	183/777 - (23%)
Similarity:	304/777 - (39%)	Gaps:	194/777 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 SESVYGTPLGATPVSSPANQSQRSQASQHSDESRNTSSTATSGGSIFPHEQYKTIKKINIGFE-- 151
            ||..:.:|.||   ..|.|    ::.||.|.|.          ||:...|...::..:|:.|.
  Rat     2 SELPFLSPEGA---RGPHN----NRGSQSSLEE----------GSVTGSEARHSLGVLNVSFSVS 49

  Fly   152 -------NIRYTTKFGVFQRETKDVLMGLTGYFKSGELSAVIGPSGAGKSTLLNILSG--YTTYG 207
                   ||:     ...|:..:.:|..::.|.:||:...::|.||:||:|||:.:||  ..|..
  Rat    50 NRVGPWWNIK-----SCQQKWDRKILKDVSLYIESGQTMCILGSSGSGKTTLLDAISGRLRRTGT 109

  Fly   208 FTGDFRVNG--NRRDLKAFKSNVAFIRQDTSLQAFLSVKEAMHFAANLKIGTHMT--HSEKRERV 268
            ..|:..|||  .|||  .|:..|:::.|.....:.|:|:|.:.:.|.|.:.:...  :.:|.|.|
  Rat   110 LEGEVFVNGCELRRD--QFQDCVSYLLQSDVFLSSLTVRETLRYTAMLALRSSSADFYDKKVEAV 172

  Fly   269 KCIL-------EAIGMYENRHTRTGQLSGGQKKRLAIALELVNNPPVLILDEPTTGLDSFTSNQL 326
            ...|       :.||.|     ..|.:|.|:::|::||.:|:.:|.|::|||||||||..|:|.:
  Rat   173 LTELSLSHVADQMIGNY-----NFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANHI 232

  Fly   327 INLLKKLAIEGRTVICTIHQPSALTFAMFDHLYAIGEGKCIYAGGAQNLLPFLGALNLHCPESYN 391
            :.||.:||...|.||.|||||.:..|..||.:..:..|:.::.|..:.:|.|.......|||..|
  Rat   233 VLLLVELARRNRIVIVTIHQPRSELFHHFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSN 297

  Fly   392 PADYLMEIATHDYDTAEDNQLEKLVALMDNGRNEDYRQSKTARVAQLAAMKKVDQLMAAGLITPV 456
            |.|:.|::      |:.|.|                     :|..::...|:|..|.:|...:.:
  Rat   298 PFDFYMDL------TSVDTQ---------------------SREREIETYKRVQMLESAFRQSDI 335

  Fly   457 TAPVMSTSVPAHFMQGNTFKPLTPINELSSRVWDSQTAGIGNAGSCCKPKKKNKSRPAIELDPSH 521
            ...::........::   ..|:.|.                        |.||        .|..
  Rat   336 CHKILENIERTRHLK---TLPMVPF------------------------KTKN--------PPGM 365

  Fly   522 LCKRQNIYATPFYRQLSILLVRTFLLIWRDSSLTTMRFAIHLITGILIGTLYFGIGNDAAQTLNI 586
            .||            |.:||.|....:.|:..:..||...:||.|:.:......:.|      |:
  Rat   366 FCK------------LGVLLRRVTRNLMRNKQVVIMRLVQNLIMGLFLIFYLLRVQN------NM 412

  Fly   587 FRYLFYTIMFIMY-----CAFSGILVK---FPLEFPIVSREH----FNRWYSLRAYYVAITLADL 639
            .:......:.::|     ..::|:|..   ||:...:..:|.    :.:|..|.||    .|..|
  Rat   413 LKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYQKWQMLLAY----VLHAL 473

  Fly   640 PIQIICSALFIVPTYLMTQQPLELWRFGMFFLIVFVTALVSQSIGLAVGAALSLKLGSILGP--- 701
            |..|:.:.:|....|.......|:.|||.|...:....|:.:.:.|.:       ||.:..|
  Rat   474 PFSIVATVIFSSVCYWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVL-------LGMVQNPNIV 531

  Fly   702 ------FFICPFLQFSGFFLMEKDAPVFLRWMFDISFLKYSLEGATMAIFGYDREPLACNELY-- 758
                  ..|...|..|||....::.|:.|:.:...:|.||..            |.|..||.|
  Rat   532 NSIVALLSISGLLIGSGFIRNIEEMPIPLKILGYFTFQKYCC------------EILVVNEFYGL 584

  Fly   759 ----------------CHLRHP-QFILKSLDMANGNYTLALIFLFGVLVFLRILAFYIMSFR 803
                            |.:... |||.|:...|...:|...:.|:..:..|.||...:...|
  Rat   585 NFTCGGSNTSVPNNPMCSMTQGIQFIEKTCPGATSRFTTNFLILYSFIPTLVILGMVVFKVR 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	78/246 (32%)
		3a01204	149..808	CDD:273361	168/717 (23%)
		ABC2_membrane	540..743	CDD:279410	47/223 (21%)
Abcg5	NP_446206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		12/44 (27%)
		ABCG_White	50..276	CDD:213201	76/237 (32%)
		3a01204	61..646	CDD:273361	164/694 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820