DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9663 and abcg4

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	XP_004916110.1	Gene:	abcg4 / 101734071	XenbaseID:	XB-GENE-22063023	Length:	639	Species:	Xenopus tropicalis

Alignment Length:	730	Identity:	272/730 - (37%)
Similarity:	394/730 - (53%)	Gaps:	121/730 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 PLGATPVS--SPANQSQRS--------QASQHSDESRNTSSTATSGGSIFPHEQYKTIKKINIGF 150
            |:.||.::  .|....|.:        :...|..::|.           |.|...::  .::|.|
Frog     8 PIQATGIAEDGPCQHPQETTLLATHLKKVENHITDARR-----------FCHLPKRS--AVDIEF 59

  Fly   151 ENIRYTTKFGVFQRET--KDVLMGLTGYFKSGELSAVIGPSGAGKSTLLNILSGYTTYGFTGDFR 213
            :::.|:.:.|...|:.  |.:|..|:|.|.|.||..::||||||||||:|||:||...|.||...
Frog    60 KDLSYSVREGPCWRKRGYKTLLKCLSGMFCSRELIGIMGPSGAGKSTLMNILAGYRESGMTGQIL 124

  Fly   214 VNGNRRDLKAFKSNVAFIRQDTSLQAFLSVKEAMHFAANLKIGTHMTHSEKRERVKCILEAIGMY 278
            |||.:|:|:.|:....:|.||..|...|:|||||..:.|||:...|  ..|::.|..||.|:|:.
Frog   125 VNGKQRELRTFRKMSCYIMQDDMLLPHLTVKEAMMVSTNLKLNEKM--EVKKKLVNEILTALGLL 187

  Fly   279 ENRHTRTGQLSGGQKKRLAIALELVNNPPVLILDEPTTGLDSFTSNQLINLLKKLAIEGRTVICT 343
            :...|||..|||||:|||||||||||||||:..||||:||||.:..|:::||..||..|||:|||
Frog   188 DCSGTRTLFLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLLNSLAQGGRTIICT 252

  Fly   344 IHQPSALTFAMFDHLYAIGEGKCIYAGGAQNLLPFLGALNLHCPESYNPADYLMEIATHDYDTAE 408
            ||||||..|.||:.||.:.:|:|||.|...:|:|:|..|.||||..:||||:::|:|:.:|
Frog   253 IHQPSAKLFEMFNKLYILSQGQCIYRGSVTHLIPYLKGLGLHCPTYHNPADFIIELASGEY---- 313

  Fly   409 DNQLEKLVALMDNGRNEDYRQSKTARVAQLAAMKKVDQLMAAGLITPVTAPVMSTSVPAHFMQGN 473
                                                      |.:.|:
Frog   314 ------------------------------------------GDLNPL----------------- 319

  Fly   474 TFKPLTPINELSSRVWDSQTAGIGNAGSCCKPKKKNKSRPAIELDPSHLCK-------RQNIYAT 531
                      |...|.|         |.|  |..::||:.. :||..| |.       ..:.:||
Frog   320 ----------LFRAVED---------GLC--PITRDKSQQT-KLDQEH-CPNDVSVHVESHTFAT 361

  Fly   532 PFYRQLSILLVRTFLLIWRDSSLTTMRFAIHLITGILIGTLYFGIGNDAAQTLNIFRYLFYTIMF 596
            ....|..||..||||.|.||:.||.:||..||..|:|||.||..||:||::..|...:||::::|
Frog   362 SSLNQFCILFKRTFLSILRDTVLTHLRFMSHLCIGVLIGLLYLHIGDDASKVFNNTGFLFFSMLF 426

  Fly   597 IMYCAFSGILVKFPLEFPIVSREHFNRWYSLRAYYVAITLADLPIQIICSALFIVPTYLMTQQPL 661
            :|:.|....::.||||..:..|||.|.||||:|||:|.|:||:|.||:|...:....|.||.||.
Frog   427 LMFAALMPTVLTFPLEMSVFLREHLNYWYSLKAYYLAKTMADVPFQIVCPVAYCSIVYWMTSQPP 491

  Fly   662 ELWRFGMFFLIVFVTALVSQSIGLAVG-AALSLKLGSILGPFFICPFLQFSGFFLMEKDAPVFLR 725
            |:.||.:|..:...||||:||:||.:| |:.||::.:.:||....|.|.|||||:..|..|.:|:
Frog   492 EVSRFLLFSALATSTALVAQSLGLLIGVASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQ 556

  Fly   726 WMFDISFLKYSLEGATMAIFGYDREPLACNELYCHLRHPQFILKSLDMANGNYTLALIFLFGVLV 790
            |...||:::|..||..:||:|.||.||.|.||.|..:.||.:|:.||:.:....:..:.|.|..:
Frog   557 WCSYISYVRYGFEGVILAIYGMDRAPLQCRELPCTFQLPQQVLQELDVEDAKLYVDFLVLGGFFL 621

  Fly   791 FLRILAFYIMSFRLR 805
            .||:||:.::.:|::
Frog   622 GLRLLAYLVLRYRVK 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	114/226 (50%)
		3a01204	149..808	CDD:273361	262/667 (39%)
		ABC2_membrane	540..743	CDD:279410	92/203 (45%)
abcg4	XP_004916110.1	3a01204	40..639	CDD:273361	266/698 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9946
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020