DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9663 and abcg8

DIOPT Version :9

Sequence 1:	NP_608760.2	Gene:	CG9663 / 33541	FlyBaseID:	FBgn0031516	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001108041.2	Gene:	abcg8 / 100136850	ZFINID:	ZDB-GENE-050517-41	Length:	684	Species:	Danio rerio

Alignment Length:	761	Identity:	188/761 - (24%)
Similarity:	331/761 - (43%)	Gaps:	126/761 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TENTVLSTSESVYGTPLGATPVSSPANQSQRSQASQHSDESRNTSSTATSGGSIFPHEQYKTIKK 145
            :::||..:.||...:......|:.|.|...|.......:|..:...|.:.|.:        .::.
Zfish     2 SDDTVFHSGESFSSSYEKQIKVALPQNTQGRDILFSSPEEDSSLYFTYSGGRN--------ELEV 58

  Fly   146 INIGFE-----NIRYTTKFGVFQ------RETKDVLMGLTGYFKSGELSAVIGPSGAGKSTLLNI 199
            .|:.:|     .|.:..|...|:      ...:.|:..|..:..||::.||||.||.||::||:|
Zfish    59 RNLNYEVDTAAQIPWYEKLSEFKMPWEMHSNKQTVIKDLNLHVHSGQMLAVIGSSGCGKTSLLDI 123

  Fly   200 LSGYTTYGF--TGDFRVNGNRRDLKAFKSNVAFIRQDTSLQAFLSVKEAMHFAANLKIGTHMTHS 262
            ::.....|.  :|:..:||........|.::|.:|||..|...|:|:|.:.|.|.|::..:.:..
Zfish   124 ITCRDEGGSMNSGEILINGKPSTRSLVKKSIAHVRQDDRLLPHLTVRETLAFVAKLRLPANFSQK 188

  Fly   263 EKRERVKCILEAIGMYENRHTRTGQ-----LSGGQKKRLAIALELVNNPPVLILDEPTTGLDSFT 322
            ::.:||..::..:.:.:..|||.|.     :|||:::|::||::|:.||.:|||||||:||||||
Zfish   189 QRDQRVDDVIAELRLRQCAHTRVGNEYVRGVSGGERRRVSIAVQLLWNPGILILDEPTSGLDSFT 253

  Fly   323 SNQLINLLKKLAIEGRTVICTIHQPSALTFAMFDHLYAIGEGKCIYAGGAQNLLPFLGALNLHCP 387
            ::.|:..|.:||...|.|:.::|||.:..|.:||.:..:..|..:|.|.|::::.:...|...||
Zfish   254 AHNLVITLYRLARGNRLVLLSVHQPRSDIFQLFDLVVLLSSGSAVYCGQAKDMVSYFTTLGYPCP 318

  Fly   388 ESYNPADYLMEIATHDYDTAEDNQLEKLVALMDNGRNEDYRQSKTARVAQLAAMKKVDQLMAAGL 452
            ...||:||.:::.:.|..|.|                      |.|:..:.|:|
Zfish   319 RYCNPSDYYVDLISIDRRTPE----------------------KEAQCLEKASM----------- 350

  Fly   453 ITPVTAPVMSTSVPAHFMQGNTFKPLTPINELSSRVWDSQTAGIGNAGSCCKP---KKKNKSRPA 514
                        :.|.|::        .:......:|.|:.         |.|   :....|.|:
Zfish   351 ------------LAAQFLE--------KVKNNEDFMWKSEV---------CGPPALEAPQSSVPS 386

  Fly   515 IELDPSHL-CKRQNIYATPFYRQLSILLVRTFLLIWRDSSLTTMRFAIH----LITGILIGTLYF 574
            :.:..|.: ..:|.........|.:.|:.|.....:||  |.|:  .:|    |:..:|||.|||
Zfish   387 VSMKESVITVSKQKDQLPGKVHQFTTLIRRQVFNDYRD--LVTL--VVHGLEALLMSLLIGFLYF 447

  Fly   575 GIGNDAAQTLNIFRYLFYTIMFIMYCAFSGILVKFPLEFPIVSREHFNR----------WYSLRA 629
            |...:.....:... |.|.|         |.|..|.:...::::.|..|          .||:..
Zfish   448 GCTEEGLSIQDTVA-LLYMI---------GALTPFAVVLDVIAKCHSERAMLYHELEDGMYSVTP 502

  Fly   630 YYVAITLADLPIQIICSALFIVPTYLMTQQPLELWRFGMFFLIVFVTALVSQSIGLAVGAAL-SL 693
            |:.|..|.:||.....:.::.||.|.:....:...||.:.||:|::|...|:|:.|.|.||| :|
Zfish   503 YFFAKVLGELPEHCAFTLVYGVPIYWLAGLNVAPDRFLLNFLLVWLTVYCSRSMALFVAAALPTL 567

  Fly   694 KLGSILGPFFICPFLQFSGFFLMEKDAPVFLRWMFDISFLKYSLEGATMAIFGYDREPLACNELY 758
            :..|.:|......|...:||.:..::..:...|...|||:::..||.....|...|.|:....|.
Zfish   568 QTSSFMGNALFTVFYLTAGFVISLENMWMVASWFSYISFMRWGFEGMLQVQFRGTRIPITIGNLT 632

  Fly   759 CHLRHPQFILKSLDMANGN-YTLALIFLFGVLVFLRILAFYIMSFR 803
            .....    :|.::|...| |.|...:|..:.|.|..:..|.:|.:
Zfish   633 VEFDG----IKVVEMMKMNQYPLFSCYLVLIAVSLVFILLYYLSLK 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9663	NP_608760.2	ABCG_EPDR	145..370	CDD:213180	78/242 (32%)
		3a01204	149..808	CDD:273361	176/693 (25%)
		ABC2_membrane	540..743	CDD:279410	58/217 (27%)
abcg8	NP_001108041.2	3a01204	47..674	CDD:273361	179/714 (25%)
		ABCG_White	72..301	CDD:213201	75/228 (33%)
		ABC2_membrane	413..617	CDD:279410	58/217 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750