DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9664 and ABCG2

DIOPT Version :9

Sequence 1:	NP_722889.1	Gene:	CG9664 / 33540	FlyBaseID:	FBgn0031515	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001335914.1	Gene:	ABCG2 / 9429	HGNCID:	74	Length:	655	Species:	Homo sapiens

Alignment Length:	657	Identity:	185/657 - (28%)
Similarity:	319/657 - (48%)	Gaps:	84/657 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QAQPNGLGPQKQKALE-------LHFSQVSYSLKGATKGSTP--------IINEACGVFKSGRLT 56
            |...||........|:       |.|..:.|.:| ...|..|        |::...|:.|.| |.
Human    14 QGNTNGFPATASNDLKAFTEGAVLSFHNICYRVK-LKSGFLPCRKPVEKEILSNINGIMKPG-LN 76

  Fly    57 AILGPSGAGKSTLLNALAGFK-LQGVTGQFLLNGRPRDIMSFRKMSAYIAQNFVMLNLLTVEETL 120
            |||||:|.|||:||:.||..| ..|::|..|:||.||. .:|:..|.|:.|:.|::..|||.|.|
Human    77 AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP-ANFKCNSGYVVQDDVVMGTLTVRENL 140

  Fly   121 RVSTDLKMPSSTAAQEKQKIIDDIIDILQLQSCRRT-----LVKNLSGGEHKRLSIGIELVTNPP 180
            :.|..|::.::....||.:.|:.:|..|.|.....:     .::.:||||.||.|||:||:|:|.
Human   141 QFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPS 205

  Fly   181 IMFFDEPTSGLDCVGSYQVICHLQRLAHDGRIVVCVVHQPGSRLFQLFDDVLVLAHGEVLYAGEQ 245
            |:|.||||:|||...:..|:..|:|::..||.::..:|||...:|:|||.:.:||.|.:::.|..
Human   206 ILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPA 270

  Fly   246 REMLPTFAQSGHICPQYYNPADFALEVCSQSSTT-------------------------ERCESL 285
            :|.|..|..:|:.|..|.|||||.|::.:..||.                         |:...:
Human   271 QEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEI 335

  Fly   286 ITQNKMMHSTASNVVKLQVDEETALIDVHKDALDLSHLRGKEQVGFWTQLSVLLRRHLRSMSRDM 350
            ...:.....|.:.:.:|...|:...|.|.|   ::|:     ...|..||..:.:|..:::..:.
Human   336 YVNSSFYKETKAELHQLSGGEKKKKITVFK---EISY-----TTSFCHQLRWVSKRSFKNLLGNP 392

  Fly   351 FAVQMRLVMHVVVALLLGVVYWQIGGDAQKIVSNVSCLFFVI---LFVFAGNAMPSILLCMQDSA 412
            .|...::::.||:.|::|.:|:.:..|:..|.:....|||:.   .|    :::.::.|.:.:..
Human   393 QASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCF----SSVSAVELFVVEKK 453

  Fly   413 VFIREYYNGWYSLGAYYLSKVLAD-LPLQLTCPTMFISIGYFMTGQPPEFQRFAMCWALCVMTAF 476
            :||.||.:|:|.:.:|:|.|:|:| ||:::....:|..|.|||.|..|:...|.:.....:|.|:
Human   454 LFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAY 518

  Fly   477 IGHFIGV-IAGSLFTMQLAIFLVPSATIPFLLFSGFFIRLNELSWFLRPICDVSFFRYIFEGLMR 540
            ....:.: ||.....:.:|..|:....:..::|||..:.|..::.:|..:...|..||.|..|..
Human   519 SASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQH 583

  Fly   541 AIYGYDRGELEC---YAT-SNFCYYR--TAEQFLKDFQMEGNEFD-WDM-----AVLGIFLILLL 593
            ..:   .|:..|   .|| :|.|.|.  |.|::|   ..:|.:.. |.:     |:..:.:|.|.
Human   584 NEF---LGQNFCPGLNATGNNPCNYATCTGEEYL---VKQGIDLSPWGLWKNHVALACMIVIFLT 642

  Fly   594 LAFFVTL 600
            :|:...|
Human   643 IAYLKLL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	88/243 (36%)
		EcfA2	23..247	CDD:224047	88/237 (37%)
		ABC2_membrane	338..539	CDD:279410	50/205 (24%)
		YadH	<388..547	CDD:223912	42/163 (26%)
ABCG2	NP_001335914.1	3a01204	55..649	CDD:273361	174/613 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850