DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9664 and AUS1

DIOPT Version :9

Sequence 1:	NP_722889.1	Gene:	CG9664 / 33540	FlyBaseID:	FBgn0031515	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_014654.1	Gene:	AUS1 / 854175	SGDID:	S000005537	Length:	1394	Species:	Saccharomyces cerevisiae

Alignment Length:	679	Identity:	181/679 - (26%)
Similarity:	294/679 - (43%)	Gaps:	111/679 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADNAVQAQPNGLGPQKQKALELHFSQVSYSLKGATKGSTPIINEACGVFKSGRLTAILGPSGAG 65
            ||.|....||.....:.||.: :.:..::|     |.|:..:||.|.|...|| |||::|.||||
Yeast   730 MALNDYNEQPITETVETQKHI-ISWKNINY-----TVGTKKLINNASGFISSG-LTALMGESGAG 787

  Fly    66 KSTLLNALAGFKLQG-VTGQFLLNGRP-RDIMSFRKMSAYIAQNFVMLNLLTVEETLRVSTDLKM 128
            |:||||.|:.....| |:|:.|::|.| .|..:|::...::.|..:.|:||:|:|:|.:|..|:.
Yeast   788 KTTLLNVLSQRVETGVVSGEILIDGHPLTDEDAFKRSIGFVQQQDLHLDLLSVKESLEISCLLRG 852

  Fly   129 PSSTAAQEKQKIIDDIIDILQLQSCRRTLVKNLSGGEHKRLSIGIELVTNPP-IMFFDEPTSGLD 192
            ....|      .:|.:.::|:|.|  ..||.:|:..:.|.||||:||||.|. ::|.||||||||
Yeast   853 DGDRA------YLDTVSNLLKLPS--DILVADLNPTQRKLLSIGVELVTKPSLLLFLDEPTSGLD 909

  Fly   193 CVGSYQVICHLQRLAHDGRIVVCVVHQPGSRLFQLFDDVLVLAH-GEVLYAGEQREMLPTFAQSG 256
            ...:..::..|::|:..|:.:.|.:|||...:...||::.:|.. ||.::.|...:....|....
Yeast   910 AEAALTIVKFLKQLSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGECVFFGPMDDACGYFMSHD 974

  Fly   257 HIC---PQYYNPADFALEVCSQSSTT---ERCESLITQNKMMHSTA----SNVVKLQVDEETALI 311
            :..   .::.|||||.::....|:::   :..|..:|.||.....:    |:|.|..|.:|||.:
Yeast   975 NTLVYDKEHDNPADFVIDAVGNSNSSAGKDTAEEALTLNKEAIDWSALWESSVEKKLVKKETARL 1039

  Fly   312 --DVHKDALDLSHLRGKEQVGFWTQLSVLLRRHLRSMSRDMFAVQMRLVMHVVVALLLGVVYWQI 374
              |.....:|.:....| |..:..||:::.||......|||..|..:..::....|.:|..:|.
Yeast  1040 EDDARASGVDYTTSLWK-QPSYLQQLALITRRQYICTKRDMTYVMAKYCLNGGAGLFIGFSFWH- 1102

  Fly   375 GGDAQKIVSNVSCLFFVILFVFAGNAMPSILL-CMQDSAVFIREYY------NGWYSLGAYYLSK 432
                  |..|:..|...|.|.|....:.|.|: .:||.|:..:|.|      :..|......||:
Yeast  1103 ------IKHNIIGLQDSIFFCFMALCVSSPLINQIQDKALKTKEVYVAREARSNTYHWTVLLLSQ 1161

  Fly   433 VLADLPLQLTCPTMFISIGYFMTG-------------------------------QPPEFQRFAM 466
            .:.:|||.||..|:|....:|..|                               ..|..|..|
Yeast  1162 SIIELPLALTSSTLFFVCAFFSCGFNNAGWSAGVFFLNYMLFAAYYSTLGLWLIYTAPNLQTAA- 1225

  Fly   467 CWALCVMTAFIGHFIGVIAG-----SLF-TMQLAIFLVPSATIPFLLFSGFFIRLNELSWFLRPI 525
                 |..|||..|.....|     ||| |....::.|.    |:..|...|:.:...:|.::
Yeast  1226 -----VFVAFIYSFTASFCGVMQPYSLFPTFWKFMYRVS----PYTYFVETFVSILLHNWEIK-- 1279

  Fly   526 CDVSFF-----------RYIFEGLMRAIYGYDRGELECYATSNFCYYRTAEQFLKDFQME----G 575
            ||:|..           ....|..:....||...: ..:....:|.|...:.|||:..|.    .
Yeast  1280 CDMSEMVPGQPLTGQSCGQFMEAFIEEYGGYLHNK-NTFTVCAYCTYTVGDDFLKNENMSYDHVW 1343

  Fly   576 NEFDWDMAVLGIFLILLLLAFFVTLNAVI 604
            ..|..:.|.:|.....:...:::|..|.|
Yeast  1344 RNFGIEWAFVGFNFFAMFAGYYLTYVARI 1372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	79/226 (35%)
		EcfA2	23..247	CDD:224047	80/227 (35%)
		ABC2_membrane	338..539	CDD:279410	56/255 (22%)
		YadH	<388..547	CDD:223912	47/213 (22%)
AUS1	NP_014654.1	3a01205	56..1369	CDD:273362	179/674 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	3	3.000