DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9664 and PDR15

DIOPT Version :9

Sequence 1:	NP_722889.1	Gene:	CG9664 / 33540	FlyBaseID:	FBgn0031515	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_010694.1	Gene:	PDR15 / 852015	SGDID:	S000002814	Length:	1529	Species:	Saccharomyces cerevisiae

Alignment Length:	578	Identity:	160/578 - (27%)
Similarity:	270/578 - (46%)	Gaps:	93/578 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ADNAVQAQPNGLGPQKQKALELHFSQVSYS--LKGATKGSTPIINEACGVFKSGRLTAILGPSGA 64
            :|||      |||..|.:|: .|:..:.|.  :||   |...|:|...|..|.|.|||::|.|||
Yeast   870 SDNA------GLGLSKSEAI-FHWRDLCYDVPIKG---GQRRILNNVDGWVKPGTLTALMGASGA 924

  Fly    65 GKSTLLNALAGFKLQGV-TGQFLLNGRPRDIMSFRKMSAYIAQNFVMLNLLTVEETLRVSTDLKM 128
            ||:|||:.||.....|| ||...::||.|| .||.:...|..|..:.|...||.|:||.|..|:.
Yeast   925 GKTTLLDCLAERVTMGVITGNIFVDGRLRD-ESFPRSIGYCQQQDLHLKTATVRESLRFSAYLRQ 988

  Fly   129 PSSTAAQEKQKIIDDIIDILQLQSCRRTLV----KNLSGGEHKRLSIGIELVTNPPIM-FFDEPT 188
            |||.:.:||.:.::::|.||::|.....:|    :.|:..:.|||:||:||...|.:: |.||||
Yeast   989 PSSVSIEEKNRYVEEVIKILEMQQYSDAVVGVAGEGLNVEQRKRLTIGVELAARPKLLVFLDEPT 1053

  Fly   189 SGLDCVGSYQVICHLQRLAHDGRIVVCVVHQPGSRLFQLFDDVLVLAH-GEVLYAGEQRE----M 248
            ||||...::.....:::||..|:.::|.:|||.:.|.|.||.:|.|.. |:.:|.|:..|    |
Yeast  1054 SGLDSQTAWDTCQLMRKLATHGQAILCTIHQPSAILMQQFDRLLFLQKGGQTVYFGDLGEGCKTM 1118

  Fly   249 LPTFAQSG-HICPQYYNPADFALEVCSQSSTTERCESLITQNKMMHSTAS-NVVKLQVDEETALI 311
            :..|...| |.||...|||::.|||...:..:             |:|.. |.|....||..|:
Yeast  1119 IDYFESKGAHKCPPDANPAEWMLEVVGAAPGS-------------HATQDYNEVWRNSDEYKAV- 1169

  Fly   312 DVHKDALDL--SHLRGKEQ-----------VGFWTQLSVLLRRHLRSMSRDMFAVQMRLVMHVVV 363
               ::.||.  .:|.|:.:           ...:.|..::..|..:...|....:..:.::.:..
Yeast  1170 ---QEELDWMEKNLPGRSKEPTAEEHKPFAASLYYQFKMVTIRLFQQYWRSPDYLWSKFILTIFN 1231

  Fly   364 ALLLGVVYWQIGGDAQKIVSNVSCLFF--VILFVFAGNAMPSILLCMQDSAVFIREYYNGWYSLG 426
            .:.:|..:::.....|.:.:.:..:|.  ||........:||.:  .|......||..:..:|..
Yeast  1232 QVFIGFTFFKADRSLQGLQNQMLSIFMYTVIFNPILQQYLPSFV--QQRDLYEARERPSRTFSWL 1294

  Fly   427 AYYLSKVLADLPLQLTCPTM-----FISIGYF----MTGQPPEFQRFAMCWALCV-MTAFIGHFI 481
            |::||:::.::|..:...|:     :.::|::    ..||..|  |.|:.|...: ...:||. :
Yeast  1295 AFFLSQIIVEIPWNILAGTIAYCIYYYAVGFYANASAAGQLHE--RGALFWLFSIAFYVYIGS-M 1356

  Fly   482 GVIAGS--------------LFTMQLA---IFLVPSATIPFLLFSGFFIRLNELSWFL 522
            |::..|              ||||.|:   :...|.....|.:   |..|::.|::.:
Yeast  1357 GLLMISFNEVAETAAHMGTLLFTMALSFCGVMATPKVMPRFWI---FMYRVSPLTYMI 1411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	88/231 (38%)
		EcfA2	23..247	CDD:224047	88/232 (38%)
		ABC2_membrane	338..539	CDD:279410	39/214 (18%)
		YadH	<388..547	CDD:223912	35/164 (21%)
PDR15	NP_010694.1	ABC_trans_N	47..162	CDD:405234
PDR15	NP_010694.1	3a01205	110..1518	CDD:273362	160/578 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	4	4.030