DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9664 and ADP1

DIOPT Version :9

Sequence 1:	NP_722889.1	Gene:	CG9664 / 33540	FlyBaseID:	FBgn0031515	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_009937.2	Gene:	ADP1 / 850369	SGDID:	S000000604	Length:	1049	Species:	Saccharomyces cerevisiae

Alignment Length:	709	Identity:	184/709 - (25%)
Similarity:	325/709 - (45%)	Gaps:	131/709 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NGLGPQK-------QKALE------------LHFSQVSYSLKGATKGST--PIINEACGVFKSGR 54
            ||||..|       :.|:.            |.|..::||:........  .::||..|:.|.|:
Yeast   353 NGLGSSKSPIRLPDEDAVNNFLQNEDDTLATLSFENITYSVPSINSDGVEETVLNEISGIVKPGQ 417

  Fly    55 LTAILGPSGAGKSTLLNALAGFKLQG-VTGQFLLNGRPRDIMSFRKMSAYIAQNFVMLNLLTVEE 118
            :.||:|.|||||:|||:.||..:..| |:|...:||...|..||.|:..::.|:..:|..|||.|
Yeast   418 ILAIMGGSGAGKTTLLDILAMKRKTGHVSGSIKVNGISMDRKSFSKIIGFVDQDDFLLPTLTVFE 482

  Fly   119 TLRVSTDLKMPSSTAAQEKQKIIDDIIDILQLQSCRRTLVKN-----LSGGEHKRLSIGIELVTN 178
            |:..|..|::|.:.:.:.|:..:..:::.|::...:..::.|     :||||.:|:||..||||:
Yeast   483 TVLNSALLRLPKALSFEAKKARVYKVLEELRIIDIKDRIIGNEFDRGISGGEKRRVSIACELVTS 547

  Fly   179 PPIMFFDEPTSGLDCVGSYQVICHLQRLAHD-GRIVVCVVHQPGSRLFQLFDDVLVLAHGEVLYA 242
            |.::|.||||||||...:..||..|.||:.| .|.:|..:|||.|.:|.|||.:::|:.||::|:
Yeast   548 PLVLFLDEPTSGLDASNANNVIECLVRLSSDYNRTLVLSIHQPRSNIFYLFDKLVLLSKGEMVYS 612

  Fly   243 GEQREMLPTFAQSGHICPQYYNPADFALEV----------------------------------- 272
            |..:::.......|:|||..||.||:.:::
Yeast   613 GNAKKVSEFLRNEGYICPDNYNIADYLIDITFEAGPQGKRRRIRNISDLEAGTDTNDIDNTIHQT 677

  Fly   273 --CSQSSTTER-----------CESLITQNKMMHSTASNVVKLQVDEETALI-DVHKDALDLSHL 323
              .|...||:|           ..||:...:.:..|.......::|..|.|: |.:||::..:.|
Yeast   678 TFTSSDGTTQREWAHLAAHRDEIRSLLRDEEDVEGTDGRRGATEIDLNTKLLHDKYKDSVYYAEL 742

  Fly   324 -----------------------RGKEQVGFWTQLSVLLRRHLRSMSRDMFAVQMRLVMHVVVAL 365
                                   .|::..||..|||:|..|..::|.|:...:....::.::::|
Yeast   743 SQEIEEVLSEGDEESNVLNGDLPTGQQSAGFLQQLSILNSRSFKNMYRNPKLLLGNYLLTILLSL 807

  Fly   366 LLGVVYWQIGGDAQKIVSNVSCLFFVILF----VFAGNAMPSILLCMQDSAVFIREYYNGWYSLG 426
            .||.:|:.:..|.....:.:...||::.:    .|.|  :.|..|   :..:||:|..|.:||..
Yeast   808 FLGTLYYNVSNDISGFQNRMGLFFFILTYFGFVTFTG--LSSFAL---ERIIFIKERSNNYYSPL 867

  Fly   427 AYYLSKVLAD-LPLQLTCPTMFISIGYFMTGQPPEFQRFAMCWALCVMTAFIGHFIGVIA-GSLF 489
            |||:||:::: :||::..|.:...|.|.|||...:...|..|..:.::.. :|..:.::. |.:|
Yeast   868 AYYISKIMSEVVPLRVVPPILLSLIVYPMTGLNMKDNAFFKCIGILILFN-LGISLEILTIGIIF 931

  Fly   490 -TMQLAIFLVPSATIPFLLFSGFFIRLNELS----WFLRPICDVSFFRYIFEGLMRAIYGYDRGE 549
             .:..:|.|.....:..|||||.||....::    .:|:   :.|.|.|.:|.|:       ..|
Yeast   932 EDLNNSIILSVLVLLGSLLFSGLFINTKNITNVAFKYLK---NFSVFYYAYESLL-------INE 986

  Fly   550 LECYATSNFCYYRTAE----QFLKDFQMEGNEFDWDMAVLGIFLILLLLAFFVTLNAVI 604
            ::........|....|    ..|..|........:|:.:|.:|.::.|:..::.|..::
Yeast   987 VKTLMLKERKYGLNIEVPGATILSTFGFVVQNLVFDIKILALFNVVFLIMGYLALKWIV 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	86/243 (35%)
		EcfA2	23..247	CDD:224047	86/232 (37%)
		ABC2_membrane	338..539	CDD:279410	53/211 (25%)
		YadH	<388..547	CDD:223912	45/169 (27%)
ADP1	NP_009937.2	EGF_CA	<70..>90	CDD:419698
ADP1	NP_009937.2	3a01204	402..1042	CDD:273361	173/655 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	5	4.840