DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9664 and Abca6

DIOPT Version :9

Sequence 1:	NP_722889.1	Gene:	CG9664 / 33540	FlyBaseID:	FBgn0031515	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_671751.2	Gene:	Abca6 / 76184	MGIID:	1923434	Length:	1624	Species:	Mus musculus

Alignment Length:	746	Identity:	157/746 - (21%)
Similarity:	259/746 - (34%)	Gaps:	217/746 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QKQKALELHFSQVSYSLKGATKGSTPIINEACGVF---KSGRLTAILGPSGAGKSTLLNALAGFK 77
            |.::|:.:.      ::|...||.:..:....|:|   ...::|||||.||||||:|||.|:|..
Mouse   473 QGKEAIRIR------NIKKEYKGKSGKVKALKGLFLDIYESQITAILGHSGAGKSSLLNILSGLY 531

  Fly    78 LQGVTGQFLLN---GRPRDIMSFRKMSAYIAQNFVMLNLLTVEETLRVSTDLK--MPSSTAAQEK 137
            :.......:.|   ...:|:...||......|:.|..:.|||:|.|.:...:|  :|.. ..||.
Mouse   532 VPTAGSVTVYNKNLSDMQDLKEIRKAIGVCPQHNVQFDALTVKENLTLFAKIKGILPQD-VEQEV 595

  Fly   138 QKIIDDIIDILQLQSCRRTLVKNLSGGEHKRLSIGIELVTNPPIMFFDEPTSGLDCVGSYQVICH 202
            |:|:.:    |.:|:.|..|.::||.|:.::|:.||..|.:|.|:..||||.|||.....::...
Mouse   596 QQILSE----LDMQNIRDDLAEHLSEGQKRKLTFGIATVGDPQILLLDEPTVGLDPFSRQRIWGF 656

  Fly   203 LQRLAHDGRIVVCVVHQPGSRLFQLFDDVLVLAHGEVLYAGEQREMLPTFAQSGHICPQY---YN 264
            |:....|..|:...         |..|:..:||..:||.|   ...|.....|..:..::   |:
Mouse   657 LKERRADHVILFST---------QFMDEADILADRKVLIA---NGALKCTGSSVFLKRKWGLGYH 709

  Fly   265 PADFALEVCSQSSTTERCESLITQNKMMHSTASNVVKLQVDEETALIDVHKDALDLSHLRGKEQV 329
            .:.|..|.|.....|......|...|:...|...:|.:...|.|:  :..:...||....|:..:
Mouse   710 LSLFMDETCDSERLTSFINHHIPYAKLKAKTKEKLVYILPLERTS--EFPEFFSDLDKYSGQGLM 772

  Fly   330 GFWTQLSVLLRRHLRSMSRDMF------------------AVQMRLVMHVVVALLLGVVYWQIGG 376
            .:...:|.|         .|:|                  |.....:..:.||      |..: .
Mouse   773 SYEVSMSTL---------NDVFLNLEGEPSTKQDFEKRETATDSESLNDMEVA------YPSL-S 821

  Fly   377 DAQKIVSNVS------CLF--------------FVILFVFAGNAMPSILLCMQDSAVFIREYYNG 421
            ..|:.||.:|      |..              |:|:.:..|.|:  :.|.::..|..:.|..|.
Mouse   822 QVQETVSTMSLWRMQVCAIARLRILKLKRERKAFLIILLLLGIAL--LPLVIEYVANALLEVKNN 884

  Fly   422 W-YSLGAYYLSKVLADLPLQLTCPTMFI---------------------------------SIGY 452
            | :....|:||.  ..||..|....:.|                                 |:.|
Mouse   885 WEFKTDLYFLSP--GQLPQGLRTSLLVINNTESNIEDFLQSLKHQNIVLEVDDFENRNATNSLSY 947

  Fly   453 ----FMTGQPPEFQRFAMC-------------------------------------------WA- 469
                .::|:..:::..|:|                                           |.
Mouse   948 NGAIIVSGRQKDYRFSAVCNTKRLHCFPILMNVISNGILHMLNHTQYIRIKEDIFSPFIVLVWTG 1012

  Fly   470 --------LCVMTAFIGHFIGVIAGSLFT-------MQLAIF-LVPS------ATIPFLLFSGFF 512
                    |||:.:...|    ||.|..:       .||.|. |.||      |.:...||||..
Mouse  1013 IQETCLFILCVICSLSPH----IAMSSVSDYKKKADSQLWISGLYPSAYWCGQAVVDISLFSGML 1073

  Fly   513 IRLNELSWFLRPICDVSFFRYIFEGLMRAIYGYDRGELECYATSNFCYYRTAEQFLKDFQMEGNE 577
            :.....|:..:.:........:|..::.|        |.|.|:..|..|..:..|.|   .:.|.
Mouse  1074 LTSYFTSYTSKLLNIDMTSEIVFSVIVLA--------LGCAASLVFLTYVISFVFGK---RKKNS 1127

  Fly   578 FDWDMAVLGIFLILLLLAFFVTLNAVIRRAL 608
            ..|.:.    ||:::.:.|....|.....||
Mouse  1128 TLWSIC----FLLVIAITFEKVANGPFNEAL 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	68/230 (30%)
		EcfA2	23..247	CDD:224047	68/231 (29%)
		ABC2_membrane	338..539	CDD:279410	54/342 (16%)
		YadH	<388..547	CDD:223912	43/276 (16%)
Abca6	NP_671751.2	rim_protein	<169..1600	CDD:130324	157/746 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000