Protein Alignment CG9664 and ABCG8

DIOPT Version :9

• Sequence 1: NP_722889.1
• Gene: CG9664 / 33540
• FlyBaseID: FBgn0031515
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: XP_011531331.1
• Gene: ABCG8 / 64241
• HGNCID: 13887
• Length: 677
• Species: Homo sapiens
• Alignment Length: 626
• Identity: 170/626 - (27%)
• Similarity: 297/626 - (47%)
• Gaps: 75/626 - (11%)

  Fly    15 PQKQKALELHFSQVSYSLKGATKGSTPIINEACGVFKSGRLTAILGPSGAGKSTLLNALAGFKLQ 79
            |..|.:.||....:|:.:                  :||::.||:|.||.|:::||:.:.|....
Human    82 PSCQNSCELGIQNLSFKV------------------RSGQMLAIIGSSGCGRASLLDVITGRGHG 128

  Fly    80 G--VTGQFLLNGRPRDIMSFRKMSAYIAQNFVMLNLLTVEETLRVSTDLKMPSSTAAQEKQKIID 142
            |  .:||..:||:|......||..|::.|:..:|..|||.|||.....:::|.:.:..::.|.::
Human   129 GKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVE 193

  Fly   143 DIIDILQLQSCRRTLVKN-----LSGGEHKRLSIGIELVTNPPIMFFDEPTSGLDCVGSYQVICH 202
            |:|..|:|:.|..|.|.|     |||||.:|:|||::|:.||.|:..||||||||...::.::..
Human   194 DVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKT 258

  Fly   203 LQRLAHDGRIVVCVVHQPGSRLFQLFDDVLVLAHGEVLYAGEQREMLPTFAQSGHICPQYYNPAD 267
            |.|||...|:|:..:|||.|.:|:|||.||::..|..:|.|..:.|:..|...|:.||:|.||||
Human   259 LSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPAD 323

  Fly   268 FALEVCSQSSTTERCESLITQNKMMHSTASNVVKLQ-------------VDEETALIDVHKDALD 319
            |.:::.| .....|.:.|.|:.|.....|..:.|::             :||:|. ::.....||
Human   324 FYVDLTS-IDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTC-VESSVTPLD 386

  Fly   320 LSHLRGKEQV-GFWTQLSVLLRRHLRSMSRDMFAVQMRLVMHVVVALLLGVVYWQIGGDAQKIVS 383
            .:.|....:: |...|.:.|:||.:.:..||:..:.:......::::.:|.:|:..|......:.
Human   387 TNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMD 451

  Fly   384 NVSCLFFVILFVFAGNAMPSILLCMQDSAVFIREYYNGWYSLGAYYLSKVLADLPLQLTCPTMFI 448
            ..:.||.:...:.....:..|..|..:.|:...|..:|.|:.|.|:.:|:|.:||.......::.
Human   452 TAALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYG 516

  Fly   449 SIGYFMTGQPPEFQRFAMCWALCVMTAFIGHFIGVIAGSLF-TMQLAIFLVPSATIPFLLFSGFF 512
            ...|::....|..|.|.:.:.|..:..|....:.:.|.:|. |..:|.|...:....|.|..||.
Human   517 MPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFM 581

  Fly   513 IRLNEL----SWFLRPICDVSFFRYIFEGLM-----RAIYGYDRGELECYATSNFCYYRTAEQFL 568
            |.|:.|    :|    |..|||.|:.|||||     |..|....|.|....        :.::.|
Human   582 INLSSLWTVPAW----ISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAV--------SGDKIL 634

  Fly   569 KDFQMEGNEFDWDMAVLGIFLILL------LLAFFVTLNAV 603
            ...:::      ...:..|:||::      ::.::|:|..:
Human   635 SVMELD------SYPLYAIYLIVIGLSGGFMVLYYVSLRFI 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	80/229 (35%)
		EcfA2	23..247	CDD:224047	80/230 (35%)
		ABC2_membrane	338..539	CDD:279410	49/205 (24%)
		YadH	<388..547	CDD:223912	45/168 (27%)
ABCG8	XP_011531331.1	ABCG_White	64..299	CDD:213201	82/234 (35%)
		3a01204	92..667	CDD:273361	165/612 (27%)
		ABC2_membrane	406..610	CDD:279410	51/207 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3602
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.770