Protein Alignment CG9664 and ABCG4

DIOPT Version :9

• Sequence 1: NP_722889.1
• Gene: CG9664 / 33540
• FlyBaseID: FBgn0031515
• Length: 609
• Species: Drosophila melanogaster
• Sequence 2: NP_001135977.1
• Gene: ABCG4 / 64137
• HGNCID: 13884
• Length: 646
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 240/645 - (37%)
• Similarity: 360/645 - (55%)
• Gaps: 55/645 - (8%)

  Fly     1 MADNAVQAQPNGLGP--------------------------------------QKQKALELHFSQ 27
            ||:.|::|...||||                                      .|:.|:::.|.:
Human     1 MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVE 65

  Fly    28 VSYSLKGA----TKGSTPIINEACGVFKSGRLTAILGPSGAGKSTLLNALAGFKLQGVTGQFLLN 88
            :|||::..    .:|...::....|.|....|..|:|||||||||.:|.|||::..|:.||.|:|
Human    66 LSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVN 130

  Fly    89 GRPRDIMSFRKMSAYIAQNFVMLNLLTVEETLRVSTDLKMPSSTAAQEKQKIIDDIIDILQLQSC 153
            ||||::.:|||||.||.|:.::|..|||.|.:.||.:||:  |...:.|::::.:|:..|.|.||
Human   131 GRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKL--SEKQEVKKELVTEILTALGLMSC 193

  Fly   154 RRTLVKNLSGGEHKRLSIGIELVTNPPIMFFDEPTSGLDCVGSYQVICHLQRLAHDGRIVVCVVH 218
            ..|....||||:.|||:|.:|||.|||:|||||||||||....:||:..::.||..||.::|.:|
Human   194 SHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258

  Fly   219 QPGSRLFQLFDDVLVLAHGEVLYAGEQREMLPTFAQSGHICPQYYNPADFALEVCS-QSSTTERC 282
            ||.::||::||.:.:|:.|:.::.|....::|.....|..||.|:|||||.:||.| :.......
Human   259 QPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPM 323

  Fly   283 ESLITQNKM--MHSTASNVVKLQVDEETALIDVHKDALDLSHLRGKEQVGFWTQLSVLLRRHLRS 345
            .....||.:  |....|:..|.:|...........|.:: ||......:   ||..:|.:|...|
Human   324 LFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIE-SHTFATSTL---TQFCILFKRTFLS 384

  Fly   346 MSRDMFAVQMRLVMHVVVALLLGVVYWQIGGDAQKIVSNVSCLFFVILFVFAGNAMPSILLCMQD 410
            :.||.....:|.:.|||:.:|:|::|..||.||.|:.:|..||||.:||:.....||::|....:
Human   385 ILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLE 449

  Fly   411 SAVFIREYYNGWYSLGAYYLSKVLADLPLQLTCPTMFISIGYFMTGQPPEFQRFAMCWALCVMTA 475
            .|||:||:.|.||||.||||:|.:||:|.|:.||.::.||.|:|||||.|..||.:..||...||
Human   450 MAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATA 514

  Fly   476 FIGHFIGVIAGSLF-TMQLAIFLVPSATIPFLLFSGFFIRLNELSWFLRPICDVSFFRYIFEGLM 539
            .:...:|::.|:.. ::|:|.|:.|...||.|||||||:....:..:|:....:|:.||.|||::
Human   515 LVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVI 579

  Fly   540 RAIYGYDRGELECYATSNFCYYRTAEQFLKDFQMEGNEFDWDMAVLGI-FLILLLLAFFV 598
            ..|||.:||:|.|  ....|.:|..:..|:...:|..:...|..|||| ||.|.|||:.|
Human   580 LTIYGMERGDLTC--LEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLV 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	98/226 (43%)
		EcfA2	23..247	CDD:224047	98/227 (43%)
		ABC2_membrane	338..539	CDD:279410	85/201 (42%)
		YadH	<388..547	CDD:223912	69/159 (43%)
ABCG4	NP_001135977.1	3a01204	44..646	CDD:273361	232/602 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950