DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9664 and E23

DIOPT Version :9

Sequence 1:	NP_722889.1	Gene:	CG9664 / 33540	FlyBaseID:	FBgn0031515	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster

Alignment Length:	701	Identity:	190/701 - (27%)
Similarity:	303/701 - (43%)	Gaps:	141/701 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QKQKALELHFSQVSYSLKGATKGSTPIINEACGVFKSGRLTAILGPSGAGKSTLLNALAGFKLQG 80
            |.|.:|:|.|..::     .......|:::..|......:.||:||||:||:|||:.|:| :...
  Fly   346 QPQHSLQLTFQNLN-----VLHNERQILSDVSGFVSPCEVLAIMGPSGSGKTTLLDCLSG-QRHI 404

  Fly    81 VTGQFLLNGRPRDIMSFRKMSAYIAQNFVMLNLLTVEETLRVSTDLKMPSSTAAQEKQKIIDDII 145
            .:|...||..|. ...:|:...|:.|..:....||:.||:..:..|::|.|....||.:.:|.|:
  Fly   405 DSGSVFLNREPL-TKKWRRRIGYVLQEEIFFPQLTLRETVVYTALLRLPESMPRAEKMRQVDHIL 468

  Fly   146 DILQLQSCRRT-----LVKNLSGGEHKRLSIGIELVTNPPIMFFDEPTSGLDCVGSYQVICHLQR 205
            :.|:|..|::|     |.:.|||||.||.:|..||:|||.:|..||||||||...:..::..|:|
  Fly   469 EALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSGLDSHSAISLMKVLKR 533

  Fly   206 LAH-DGRIVVCVVHQPGSRLFQLFDDVLVLAHGEVLYAGEQREMLPTFAQSGHICPQYYNPADFA 269
            .|. :.:.:|..||||.|::|.:||.:|:|..|...|.|:.:.:...|...|.....:||||||.
  Fly   534 YAQLEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFEDIGVTIKPHYNPADFV 598

  Fly   270 LEV--------------------------CSQSS-----------TTERCESLIT---------- 287
            ||.                          |..||           ..::.:|::.
  Fly   599 LEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQADSILIDDIINNYYNQ 663

  Fly   288 -------QNKMMHSTASNVVKLQVDEETA--LI----------------DVHK---------DAL 318
                   |.:.:|.| ||..:::.|||.|  |:                |.|.         .|.
  Fly   664 RSNRHHHQYENLHHT-SNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSDCHSYSAGSGPGHSAD 727

  Fly   319 D--LSHLRGKEQVGFWTQLSVLLRRHLRSMSRDMFAVQMRLVMHVVVALLLGVVYWQIGGDAQKI 381
            |  ||:     ...|.||..||..|:.|.....|.: ::.....:.:||:.|.:::|:....:.:
  Fly   728 DDWLSY-----PTSFHTQFCVLSSRNFREAKPRMLS-KLNWFQTIGLALMAGAIWFQLPRTEEFL 786

  Fly   382 VSNVSCLFFV----ILFVFAG--NAMPSILLCMQDSAVFIREYYNGWYSLGAYYLSKVLADLPLQ 440
            ......:||.    :||...|  |:.||      :..|..:|..:|.|.|.||||:|:.|:|||.
  Fly   787 HDLQGWMFFSQTYWMLFALFGALNSFPS------EREVVSKERRSGAYRLSAYYLAKMCAELPLV 845

  Fly   441 LTCPTMFISIGYFMTGQPPEFQRFAMCWALCVMTAF---IGHFIGVIAGSLFTMQLAIFLVPSAT 502
            :|.||:::.|.|.|.|.......|.|...|.:.|..   :|.|||...   ..|.::|.|....|
  Fly   846 ITLPTVYLMISYPMLGCTSLKLFFLMLIFLLINTIVAQSVGFFIGACC---MDMNVSITLSALYT 907

  Fly   503 IPFLLFSGFF-IRLNE-LSWFLRPICDVSFFRYIFEGLMRAIYGYDRGELECYATSNF--CYYRT 563
            :...||.|:. .|:.| |||    |...|...|.::. |:.:...:...:.|.:.|::  |..::
  Fly   908 LATQLFGGYLSSRIPEGLSW----IRYTSMIHYAYQN-MQILEFREGAAIGCGSPSSYEICKQQS 967

  Fly   564 A-----EQFLKDFQMEGNEFDWDMAVLGIFLILLLLAFFVTLNAVIRRALR 609
            .     |:.||  ........|    |...::::....|..|...:.|.||
  Fly   968 TEFIPYEEILK--AQNSTSPLW----LNTLILMMFFLVFRCLGYAVLRFLR 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	79/228 (35%)
		EcfA2	23..247	CDD:224047	79/229 (34%)
		ABC2_membrane	338..539	CDD:279410	60/211 (28%)
		YadH	<388..547	CDD:223912	53/169 (31%)
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	79/228 (35%)
		3a01204	363..1009	CDD:273361	182/674 (27%)
		ABC2_membrane	744..943	CDD:279410	61/213 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I2350
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	7	6.920