DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9664 and Abcg4

DIOPT Version :9

Sequence 1:	NP_722889.1	Gene:	CG9664 / 33540	FlyBaseID:	FBgn0031515	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001100286.2	Gene:	Abcg4 / 300664	RGDID:	1305840	Length:	646	Species:	Rattus norvegicus

Alignment Length:	645	Identity:	244/645 - (37%)
Similarity:	361/645 - (55%)	Gaps:	55/645 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADNAVQAQPNGLGP--------------------------------------QKQKALELHFSQ 27
            ||:.|::|...||||                                      .|:.|:::.|.:
  Rat     1 MAEKALEAVGCGLGPGAVAMAVALEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVE 65

  Fly    28 VSYSLKGA----TKGSTPIINEACGVFKSGRLTAILGPSGAGKSTLLNALAGFKLQGVTGQFLLN 88
            :|||::..    .:|...::....|.|....|..|:|||||||||.:|.|||::..|:.||.|:|
  Rat    66 LSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVN 130

  Fly    89 GRPRDIMSFRKMSAYIAQNFVMLNLLTVEETLRVSTDLKMPSSTAAQEKQKIIDDIIDILQLQSC 153
            |||||:.:|||||.||.|:.::|..|||.|.:.||.:||:  |...:.|::::.:|:..|.|.||
  Rat   131 GRPRDLRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKL--SEKQEVKKELVTEILTALGLMSC 193

  Fly   154 RRTLVKNLSGGEHKRLSIGIELVTNPPIMFFDEPTSGLDCVGSYQVICHLQRLAHDGRIVVCVVH 218
            ..|....||||:.|||:|.:|||.|||:|||||||||||....:||:..::.|||.||.|:|.:|
  Rat   194 SHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAHGGRTVICTIH 258

  Fly   219 QPGSRLFQLFDDVLVLAHGEVLYAGEQREMLPTFAQSGHICPQYYNPADFALEVCS-QSSTTERC 282
            ||.::||::||.:.:|:.|:.::.|....::|.....|..||.|:|||||.:||.| :.......
  Rat   259 QPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPM 323

  Fly   283 ESLITQNKM--MHSTASNVVKLQVDEETALIDVHKDALDLSHLRGKEQVGFWTQLSVLLRRHLRS 345
            .....||.:  |....|:..|.:|...........|.:: ||......:   ||..:|.||...|
  Rat   324 LFRAVQNGLCTMAEKKSSPEKNEVPAHCPTCPPELDPIE-SHTFATSTL---TQFCILFRRTFLS 384

  Fly   346 MSRDMFAVQMRLVMHVVVALLLGVVYWQIGGDAQKIVSNVSCLFFVILFVFAGNAMPSILLCMQD 410
            :.||.....:|.:.||::.:|:|::|..||.||.|:.:|...|||.:||:.....||::|....:
  Rat   385 ILRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDASKVFNNTGFLFFSMLFLMFAALMPTVLTFPLE 449

  Fly   411 SAVFIREYYNGWYSLGAYYLSKVLADLPLQLTCPTMFISIGYFMTGQPPEFQRFAMCWALCVMTA 475
            .|||:||:.|.||||.||||:|.:||:|.|:.||.::.||.|:|||||.|..||.:..||.:.||
  Rat   450 MAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALSIATA 514

  Fly   476 FIGHFIGVIAGSLFT-MQLAIFLVPSATIPFLLFSGFFIRLNELSWFLRPICDVSFFRYIFEGLM 539
            .:...:|::.|:..| :|:|.|:.|...||.|||||||:....:..:|:....:|:.||.||||:
  Rat   515 LVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGLI 579

  Fly   540 RAIYGYDRGELECYATSNFCYYRTAEQFLKDFQMEGNEFDWDMAVLGI-FLILLLLAFFV 598
            ..|||.:||.|.|  ..:.|.:|..:..|.:..:|..:...|..|||| ||.|.|||:.|
  Rat   580 LTIYGMERGHLTC--LEDHCPFRDPQIILHELDVEEAKLYMDFLVLGIFFLALRLLAYLV 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	101/226 (45%)
		EcfA2	23..247	CDD:224047	101/227 (44%)
		ABC2_membrane	338..539	CDD:279410	85/201 (42%)
		YadH	<388..547	CDD:223912	71/159 (45%)
Abcg4	NP_001100286.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.880