DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9664 and Abca5

DIOPT Version :9

Sequence 1:	NP_722889.1	Gene:	CG9664 / 33540	FlyBaseID:	FBgn0031515	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_775429.1	Gene:	Abca5 / 286970	RGDID:	628661	Length:	1642	Species:	Rattus norvegicus

Alignment Length:	683	Identity:	149/683 - (21%)
Similarity:	259/683 - (37%)	Gaps:	215/683 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QKALELHFSQVSYSLKGATKGSTPIINEACGVFKSGRLTAILGPSGAGKSTLLNALAGFKLQGVT 82
            ::|:.:...|.:|..|..|..:  :.|.:..::: |::||:||.||.|||||:|.|.|.......
  Rat   475 KEAIRISGIQKAYRKKNETVEA--LRNLSFDIYE-GQITALLGHSGTGKSTLMNILCGLCPPSDG 536

  Fly    83 GQFLLNGRPRDI---MSFRKMSAYIAQNFVMLNLLTVEETLRVSTDLK-MPSSTAAQEKQKIIDD 143
            ...:...|..:|   ...|||.....|:.:..::|||||.|.:...:| :|::...||.||::.|
  Rat   537 FASIYGHRVSEIDEMFEARKMIGICPQSDMNFDVLTVEENLSILASVKGIPANNIIQEVQKVLLD 601

  Fly   144 IIDILQLQSCRRTLVKNLSGGEHKRLSIGIELVTNPPIMFFDEPTSGLD-CVGSYQVICHLQRLA 207
                |.:|:.:....|.||||:.::||:||.::.||.|:..||||:|:| |  |..::.:|.:..
  Rat   602 ----LDMQAIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPC--SRHIVWNLLKYR 660

  Fly   208 HDGRIVVCVVHQPGSRLFQLFDDVLVLAHGEVLYAGEQREMLPTFAQSGHICPQY---YNPADFA 269
            ...|:.|...|        ..|:..:||..:.:.:   :.||.....|..:..::   |..:.:.
  Rat   661 KANRVTVFSTH--------FMDEADILADRKAVIS---QGMLKCVGSSIFLKSKWGIGYRLSMYI 714

  Fly   270 LEVCSQSSTTERCESLITQN--------------------KMM------------HS-------- 294
            ...|:    ||...||:.|:                    |.|            ||
  Rat   715 DRYCA----TESLSSLVRQHIPAAALLQQNDQQIVYSLPFKDMDKFSGLFSALDIHSNLGVISYG 775

  Fly   295 ----TASNV-VKLQV-----------------DEET---ALIDVHKDALDLSHLRGK--EQVGFW 332
                |..:| :||:|                 :|||   :..::.:..|.||..:..  ..:..|
  Rat   776 VSMTTLEDVFLKLEVEAEIDQADYSVFTQQPREEETDSKSFDEMEQSLLILSETKASLVSTMSLW 840

  Fly   333 -TQLSVLLRRHLRSMSRD-------------MFAVQ--MRLVMH-----VVVALLLGVVYWQIGG 376
             .|:|.:.:.|..|:.|:             .||||  |.||.|     ||...|:..:|:...|
  Rat   841 KQQVSTIAKFHFLSLKRESKSVRSVLLLLLIFFAVQIFMFLVHHSFKNAVVPIKLVPDLYFLKPG 905

  Fly   377 D-----------AQKIVSNVSCL--FF----VILFVFAG----NAMP-----SILLCMQD---SA 412
            |           .....|:::.|  ||    :|:.:|..    :|.|     :::...:|   :|
  Rat   906 DKPHKYKTSLLLQNSTDSDINDLIDFFTQQNIIVAMFNDSDYVSAAPHSAALNVVQSEKDYVFTA 970

  Fly   413 VF--------------IREYYNGWYSLGAYYLS-------------KVLADLPLQLTCPTMFISI 450
            ||              |..||       .|:|:             :.:.|:..::........:
  Rat   971 VFNSTMVYSLPVMMNIISNYY-------LYHLNVTDTIQIWSTPFIQEITDIVFKVELYFQAALL 1028

  Fly   451 GYFMTGQPPEFQRFAMCWALCVMTAFIGHFIGVIAGSLFTMQLAIFLVPSATIPFLLFSGFFIRL 515
            |..:|..||.|          .|.....|.|     ..:|......|:|||
  Rat  1029 GIIVTAMPPYF----------AMENAENHKI-----KAYTQLKLSGLLPSA-------------- 1064

  Fly   516 NELSWFLRPICDVSFFRYIFEGLMRAIYGYDRG 548
               .|..:.:.|:..|..:...::.:::.:..|
  Rat  1065 ---YWIGQAVVDIPLFFVVLTLMLGSLFAFHHG 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	69/227 (30%)
		EcfA2	23..247	CDD:224047	68/228 (30%)
		ABC2_membrane	338..539	CDD:279410	51/276 (18%)
		YadH	<388..547	CDD:223912	33/203 (16%)
Abca5	NP_775429.1	ABC2_membrane_3	<214..416	CDD:289468
		CcmA	476..788	CDD:224054	85/335 (25%)
		ABC_subfamily_A	478..701	CDD:213230	71/242 (29%)
		ABC2_membrane_3	<957..1224	CDD:289468	27/177 (15%)
		CcmA	1288..1615	CDD:224054
		ABC_subfamily_A	1290..1521	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000