DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9664 and Abcg2

DIOPT Version :9

Sequence 1:	NP_722889.1	Gene:	CG9664 / 33540	FlyBaseID:	FBgn0031515	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_001342406.1	Gene:	Abcg2 / 26357	MGIID:	1347061	Length:	657	Species:	Mus musculus

Alignment Length:	666	Identity:	192/666 - (28%)
Similarity:	321/666 - (48%)	Gaps:	100/666 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QAQPNGLGPQKQKALE-------LHFSQVSYSLK---GATKGST---PIINEACGVFKSGRLTAI 58
            |...|||.....:|:.       |.|..::|.:|   |.....|   .|:::..|:.|.| |.||
Mouse    14 QRNNNGLPRMNSRAVRTLAEGDVLSFHHITYRVKVKSGFLVRKTVEKEILSDINGIMKPG-LNAI 77

  Fly    59 LGPSGAGKSTLLNALAGFK-LQGVTGQFLLNGRPRDIMSFRKMSAYIAQNFVMLNLLTVEETLRV 122
            |||:|.|||:||:.||..| .:|::|..|:||.|:. ..|:..|.|:.|:.|::..|||.|.|:.
Mouse    78 LGPTGGGKSSLLDVLAARKDPKGLSGDVLINGAPQP-AHFKCCSGYVVQDDVVMGTLTVRENLQF 141

  Fly   123 STDLKMPSSTAAQEKQKIIDDIIDILQLQSCRRT-----LVKNLSGGEHKRLSIGIELVTNPPIM 182
            |..|::|::....||.:.|:.||..|.|:....:     .::.:||||.||.|||:||:|:|.|:
Mouse   142 SAALRLPTTMKNHEKNERINTIIKELGLEKVADSKVGTQFIRGISGGERKRTSIGMELITDPSIL 206

  Fly   183 FFDEPTSGLDCVGSYQVICHLQRLAHDGRIVVCVVHQPGSRLFQLFDDVLVLAHGEVLYAGEQRE 247
            |.||||:|||...:..|:..|:|::..||.::..:|||...:|:|||.:.:||.|::::.|..::
Mouse   207 FLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGKLVFHGPAQK 271

  Fly   248 MLPTFAQSGHICPQYYNPADFALEVCSQSSTTERCESLITQNKMMHSTASNVVKLQVDEETALID 312
            .|..||.:|:.|..|.|||||.|:|.:..|      |.:..|:......:|..:.....|..:|:
Mouse   272 ALEYFASAGYHCEPYNNPADFFLDVINGDS------SAVMLNREEQDNEANKTEEPSKGEKPVIE 330

  Fly   313 -----------VHKDALDLSHLRG----------KEQV---GFWTQLSVLLRRHLRSMSRDMFAV 353
                       ..:...:|..|.|          ||.|   .|..||..:.||..:::..:..|.
Mouse   331 NLSEFYINSAIYGETKAELDQLPGAQEKKGTSAFKEPVYVTSFCHQLRWIARRSFKNLLGNPQAS 395

  Fly   354 QMRLVMHVVVALLLGVVYWQIGGDAQKIVSNVSCLFFVI---LFVFAGNAMPSILLCMQDSAVFI 415
            ..:|::.|::.|::|.:|:.:..||..:.:....|||:.   .|    :::.::.|.:.:..:||
Mouse   396 VAQLIVTVILGLIIGAIYFDLKYDAAGMQNRAGVLFFLTTNQCF----SSVSAVELFVVEKKLFI 456

  Fly   416 REYYNGWYSLGAYYLSKVLAD-LPLQLTCPTMFISIGYFMTGQPPEFQRFAMCWALCVMTAFIGH 479
            .||.:|:|.:.:|:..||::| ||::.....:|..|.|||.|.......|.:.....:|.|:...
Mouse   457 HEYISGYYRVSSYFFGKVMSDLLPMRFLPSVIFTCILYFMLGLKKTVDAFFIMMFTLIMVAYTAS 521

  Fly   480 FIGV-IAGSLFTMQLAIFLVPSATIPFLLFSGFFIRLNE----LSWFLRPICDVSFF---RYIFE 536
            .:.: ||.....:.:|..|:..|.:..:||||..:.|..    |||       :.:|   ||.|.
Mouse   522 SMALAIATGQSVVSVATLLMTIAFVFMMLFSGLLVNLRTIGPWLSW-------LQYFSIPRYGFT 579

  Fly   537 GLMRAIYGYDRGELEC---YATSN--------FCYYRTAEQFLKDFQMEGNEFD-WDM-----AV 584
            .|.   |....|:..|   ..|.|        .|   |..::|.:   :|.|.. |.:     |:
Mouse   580 ALQ---YNEFLGQEFCPGFNVTDNSTCVNSYAIC---TGNEYLIN---QGIELSPWGLWKNHVAL 635

  Fly   585 LGIFLILLLLAFFVTL 600
            ..:.:|.|.:|:...|
Mouse   636 ACMIIIFLTIAYLKLL 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	89/241 (37%)
		EcfA2	23..247	CDD:224047	89/235 (38%)
		ABC2_membrane	338..539	CDD:279410	53/212 (25%)
		YadH	<388..547	CDD:223912	45/170 (26%)
Abcg2	NP_001342406.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		4/9 (44%)
Abcg2	NP_001342406.1	3a01204	46..651	CDD:273361	183/632 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850