DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9664 and pdr1

DIOPT Version :9

Sequence 1:	NP_722889.1	Gene:	CG9664 / 33540	FlyBaseID:	FBgn0031515	Length:	609	Species:	Drosophila melanogaster
Sequence 2:	NP_593995.1	Gene:	pdr1 / 2543363	PomBaseID:	SPAPB24D3.09c	Length:	1396	Species:	Schizosaccharomyces pombe

Alignment Length:	624	Identity:	146/624 - (23%)
Similarity:	262/624 - (41%)	Gaps:	110/624 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ELHFSQVSYSLKGATKGSTPIINEACGVFKSGRLTAILGPSGAGKSTLLNALAGFKLQG-VTGQF 85
            :|:|:.|:.:.|      ..|:....|..|...|||:||.:.:|||.||..|:...:.| |.|:.
pombe   762 DLNFTVVTKTSK------KQILTNVSGYLKKNTLTALLGENKSGKSVLLRILSQRGIAGSVEGEI 820

  Fly    86 LLNG--RPRDIMSFRKMSAYIAQNFVMLNLLTVEETLRVSTDLKMPSSTAAQEKQKIIDDIIDIL 148
            .|:|  .|:::   ||...|:.:|.:.::..||.||||:...|:.....:..|:...::.:||.|
pombe   821 TLSGLKNPKNL---RKRIGYVRKNPLFISEYTVRETLRLHAALRQSKQRSLSEQYAYVEYVIDFL 882

  Fly   149 QLQSCRRTLVKNLSGG---EHKR-LSIGIELVTNP-PIMFFDEPTSGLDCVGSYQVICHLQRLAH 208
            .|......:|.::..|   .||| |||.:||...| .|:..|||.:|||...::.::|.||:||.
pombe   883 GLGEVADFIVGDMGKGLSLYHKRLLSIAVELSARPGSILLLDEPANGLDSQSAWMLVCILQKLAR 947

  Fly   209 DGRIVVCVVHQPGSRLFQLFDDVLVL-AHGEVLY---AGEQREMLPTFAQSGHICPQY-YNPADF 268
            .|..::|.|.||.||:.:|||.:|:| .:|..:|   .|.....|..:.:..|...:: .:.|||
pombe   948 SGLSILCSVSQPSSRILELFDMMLILDLNGNTVYYDTMGRDLSKLVNYFKRIHGTNEHSKDTADF 1012

  Fly   269 ALEVCSQSSTTERCESLITQNKMMH---STASNVVKLQVDEETALIDVHKDALDLSHLRGKE--- 327
            .|          .|...:.|.....   :.||.....|:.|....|      :|...|...:
pombe  1013 VL----------HCIQFLKQGPEFDYAGAWASTNTHKQIIEHVNFI------MDNPELTDDDFPN 1061

  Fly   328 ----QVGFWTQLSVLLRRHLRSMSRDMFAVQMRLVMHVVVALLLGVVYWQIGGDAQKIVSNVSCL 388
                ...|:.|:..:..|:..:..||...::.|:..::|..|::|..:::.|...::..:.:...
pombe  1062 ETRFMTSFFFQIYKISMRNFVAYWRDSSLLRARVAFNIVAGLIIGFSFYKQGVGVEETQNKMFSA 1126

  Fly   389 FFVILFVFAGNAMPSILLCMQDSAVFIREYYNGW------YSLGAYYLSKVLADLPLQLTCPTMF 447
            :.:.:      |..|.:..:|...::.|..|..:      ||..|:.::..|.:..:.....|:|
pombe  1127 YMLTV------ASTSTMNGLQPKFIYFRSIYEQYEQNTAIYSRTAFIIAFFLVEAVINCCFATLF 1185

  Fly   448 ISIGYFMTG------QPPEFQRFA----MCWALCVMTAFIGHFIGVIAGSLFTMQLAIFLVPSAT 502
            ....|:.:|      ..|.:..||    |.:.|...|..||  |..|:.|:.|   |..:..:|.
pombe  1186 FFGWYYPSGFYEFNHNIPFYGGFAWLMLMIFTLYYTTLGIG--IATISPSIGT---ASIISGTAF 1245

  Fly   503 IPFLLFSGFFIRLNELSWFLRPICDVSFFRYIFEGLMRAIY-------------------GYDRG 548
            :....|:|.......:..|.:.:..:|.::|..||::..:.                   .|..|
pombe  1246 VFIQYFNGMIQLPGVIVGFWKWMDALSPYKYFLEGMIGGVLHDAPITCEKFEIHYVDPPPNYSCG 1310

  Fly   549 EL----------------ECYATSNFCYYRTAEQFLKDF 571
            |.                |.|::..:|.|:.|::.:..|
pombe  1311 EYFSSFLNSSGHGIVYNPEAYSSCQYCPYKNADELMVGF 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9664	NP_722889.1	ABCG_EPDR	20..243	CDD:213180	77/232 (33%)
		EcfA2	23..247	CDD:224047	78/235 (33%)
		ABC2_membrane	338..539	CDD:279410	42/216 (19%)
		YadH	<388..547	CDD:223912	35/193 (18%)
pdr1	NP_593995.1	3a01205	40..1382	CDD:273362	146/624 (23%)
		ABCG_PDR_domain1	70..302	CDD:213200
		ABC2_membrane	421..620	CDD:279410
		PDR_CDR	634..>701	CDD:283960
		ABCG_PDR_domain2	755..983	CDD:213199	77/229 (34%)
		ABC2_membrane	1076..1284	CDD:279410	42/218 (19%)
		PDR_CDR	<1349..>1377	CDD:283960	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	79	1.000	Domainoid score	I2350
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9277
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	3	3.000