| Sequence 1: | NP_000856.1 | Gene: | HTR1E / 3354 | HGNCID: | 5291 | Length: | 365 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_034613.2 | Gene: | Htr5b / 15564 | MGIID: | 96284 | Length: | 370 | Species: | Mus musculus |
| Alignment Length: | 355 | Identity: | 124/355 - (34%) |
|---|---|---|---|
| Similarity: | 188/355 - (52%) | Gaps: | 61/355 - (17%) |
- Green bases have known domain annotations that are detailed below.
|
Human 23 MLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSII--YIVM 85
Human 86 DRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTIS 150
Human 151 IFISMPPLF--W------RSHR-RLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIY 206
Human 207 HAAKSLYQKR-------GSSRHLSNRSTDSQNSF-ASCKLTQTFCVSDFSTSDPTTEFEKFHASI 263
Human 264 RIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADF 328
Human 329 LTWLGYVNSLINPLLYTSFNEDFKLAFKKL 358 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HTR1E | NP_000856.1 | 7tmA_5-HT1E | 23..355 | CDD:320457 | 120/350 (34%) |
| TM helix 1 | 24..50 | CDD:320457 | 9/25 (36%) | ||
| TM helix 2 | 57..83 | CDD:320457 | 14/27 (52%) | ||
| TM helix 3 | 95..125 | CDD:320457 | 17/29 (59%) | ||
| Agonist binding. /evidence=ECO:0000250 | 98..107 | 4/8 (50%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 119..121 | 1/1 (100%) | |||
| TM helix 4 | 137..159 | CDD:320457 | 8/21 (38%) | ||
| TM helix 5 | 179..208 | CDD:320457 | 13/28 (46%) | ||
| TM helix 6 | 284..314 | CDD:320457 | 13/29 (45%) | ||
| Agonist binding. /evidence=ECO:0000250 | 304..308 | 2/3 (67%) | |||
| TM helix 7 | 323..348 | CDD:320457 | 11/24 (46%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 340..344 | 3/3 (100%) | |||
| Htr5b | NP_034613.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..36 | ||
| 7tm_1 | 69..351 | CDD:278431 | 111/323 (34%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| HGNC | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| NCBI | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG46042 | |
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.920 | |||||