Protein Alignment OtopLb and OTOP2

DIOPT Version :9

• Sequence 1: NP_608758.1
• Gene: OtopLb / 33539
• FlyBaseID: FBgn0031514
• Length: 797
• Species: Drosophila melanogaster
• Sequence 2: NP_835454.1
• Gene: OTOP2 / 92736
• HGNCID: 19657
• Length: 562
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 136/624 - (21%)
• Similarity: 230/624 - (36%)
• Gaps: 186/624 - (29%)

  Fly   254 VLLGVCLPITEVISDQIPTYVYQGFYVYLYVGSILFVIFLYISAFRNRSLFNALKDYHEKNSNVH 318
            |||..|..|:....:::..|...   |:..:.:::.:..|:|       ||..|:..   .....
Human    39 VLLLACTLISGGAFNKVAVYDTD---VFALLTAMMLLATLWI-------LFYLLRTV---RCPCA 90

  Fly   319 LKHKVTHFGSFYLRVGAIAFAIGTMVYSGLEFG---QFFELNGHPGCRDVFVAITPICRMVLCIA 380
            :.::..|.|..:||.|.:.|.|.|::....:.|   .|||      |:.....:.|:.:.|..|.
Human    91 VPYRDAHAGPIWLRGGLVLFGICTLIMDVFKTGYYSSFFE------CQSAIKILHPLIQAVFVII 149

  Fly   381 QVQFIFLNT-----TYMDMARHKVTSRFGLMHMVATNLCEWLYVLVEETKHEIFHISQHEVDPAH 440
            |..|::::.     .::|:      :..|||..:.|||..|:..:|:|:.|:     .|....:|
Human   150 QTYFLWVSAKDCVHVHLDL------TWCGLMFTLTTNLAIWMAAVVDESVHQ-----SHSYSSSH 203

  Fly   441 DLVIHNSSMSRTDWAAVNESLHQHHHHHALNNTLVANVSSVIVNMTITPSPTPAAFSGCSRTTIM 505
            ....|...:|               ..||.|                     |.....|..:|.:
Human   204 SNASHARLIS---------------DQHADN---------------------PVGGDSCLCSTAV 232

  Fly   506 GALVQQLSPFLFPCTIEYSLICAVILFEMWKTVKSIPDIDKTRKNSVKPAAAKPAHHFSVDCSQS 570
            ..:.||...:|:|..|||||..:.:|:.|||.|...             .|:.|.|..:......
Human   233 CQIFQQGYFYLYPFNIEYSLFASTMLYVMWKNVGRF-------------LASTPGHSHTPTPVSL 284

  Fly   571 HKGLFF-----GILIIVMTIISMIMYFVLYTQPGYELVATQEVTLWETFMYFMCAAAV----ITG 626
            .:..||     |:|:.|:.:...|:|.|..:..|..  ..|.:.::.:| ..:|....    ::|
Human   285 FRETFFAGPVLGLLLFVVGLAVFIIYEVQVSGDGSR--TRQALVIYYSF-NIVCLGLTTLVSLSG 346

  Fly   627 MILMR-DLRYIKNTSDEHH---SMDLDNLLLIVAQTGVYLYGMFSILGSYFAKWDTVPDRVEG-- 685
            .|:.| |.|.:     :||   :..||..||:.|..|.|....:||:.....   |..|.:.|
Human   347 SIIYRFDRRAM-----DHHKNPTRTLDVALLMGAALGQYAISYYSIVAVVAG---TPQDLLAGLN 403

  Fly   686 IIAEVFGVVQTSLQTMFILHSSHRRCRG-----------------TN------------------ 715
            :...:..:.|.:.|.|||:.|.||...|                 ||
Human   404 LTHALLMIAQHTFQNMFIIESLHRGPPGAEPHSTHPKEPCQDLTFTNLDALHTLSACPPNPGLVS 468

  Fly   716 ------------------QVRRKPGREIITFLLVANIAIW----------FVNTLIKGRAVFRES 752
                              |.||:..::|..|||:.|:.:|          |.||:
Human   469 PSPSDQREAVAIVSTPRSQWRRQCLKDISLFLLLCNVILWIMPAFGARPHFSNTV---------- 523

  Fly   753 HLEFFGVWGWTIITHISMPLAIFYRFHSTICLFEVWKIT 791
            .::|:|...|.:|.:|.:|..||||.|:...|.||:.::
Human   524 EVDFYGYSLWAVIVNICLPFGIFYRMHAVSSLLEVYVLS 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:281218	117/533 (22%)
OTOP2	NP_835454.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Otopetrin	103..548	CDD:367383	116/531 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8528
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.930