DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment OtopLb and OtopLc

DIOPT Version :9

Sequence 1:	NP_608758.1	Gene:	OtopLb / 33539	FlyBaseID:	FBgn0031514	Length:	797	Species:	Drosophila melanogaster
Sequence 2:	NP_001303575.1	Gene:	OtopLc / 7354434	FlyBaseID:	FBgn0259150	Length:	1596	Species:	Drosophila melanogaster

Alignment Length:	845	Identity:	303/845 - (35%)
Similarity:	429/845 - (50%)	Gaps:	156/845 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 HYHHDVISKGNDSHRSSDACEYITISAPKKSGSFS-RSPPSSLPTSVPGTPRHSVAATSNQVIRY 89
            |:|:.:..:....|..:.....:.:..|....|:: ..||.|..:|.|...|....|.....|.
  Fly   688 HHHYHLPHQFQHPHHQNHHTHSVRVPTPTVPSSYAPPPPPDSGSSSSPVDRRRLFMAGVAPPIA- 751

  Fly    90 ARTSCDHCGHHSIPVMSPHPISPLAKSQTNLDLVEHGSQRQALLPLPTVGMHHEDSACTLQVSRR 154
                   .|..|:..|...|...::..:.:   ...|||            ||    .|:..|..
  Fly   752 -------AGAGSLMAMPAEPAVAISPGRVS---ARSGSQ------------HH----VTIDESSL 790

  Fly   155 PSLL--LQEILTQRPPLFGRRDGNGFLSPRTAKNGNLQGTASGSTATINFQSGATSARNGSTAFF 217
            ||..  :||.......:.|..||:|   .|....|.  |..|....:....|.:..|.:||.|
  Fly   791 PSHKGNIQETPGPSGLIIGGGDGDG---DRDIGGGG--GPDSSDPPSSPGGSSSQPALSGSQA-- 848

  Fly   218 DNGAKSFQAKQQKDKN-------RRT--------------GNDAISSALSATYCKLLVLLGVCLP 261
             :|..:......:..|       :||              ..||:::..||.|.||||::|:..|
  Fly   849 -DGQLALMYHSHQLTNYPVLPAIKRTHRPSFVYPPMPRVKAGDALATLFSALYGKLLVVMGIAFP 912

  Fly   262 ITEVISDQIPTYVYQGFYVYLYVGSILFVIFLYISAFRNRSLF---------NALK-------DY 310
            :.||||..||...|:.:|:|||:||::|::|:|.:....|...         :|.|       |.
  Fly   913 MAEVISTYIPPSFYEVYYLYLYIGSMIFLLFMYATLIWGRPKLPVPIASPSKSATKASGTDSMDE 977

  Fly   311 HEKNSN-VH-----------------LKHKVTHFGSFYLRVGAIAFAIGTMVYSGLEFGQFFELN 357
            .:.:|| ||                 |..:..|:||||||:||:||.||:|:||||||||:||||
  Fly   978 SDTDSNSVHHRLPPPIPVRRPSLLSPLGRRDAHYGSFYLRMGAVAFGIGSMIYSGLEFGQYFELN 1042

  Fly   358 GHPGCRDVFVAITPICRMVLCIAQVQFIFLNTTYMDMARHKVTSRFGLMHMVATNLCEWLYVLVE 422
            ....|.:|.:|:||..||.....|:.|||||...:.:.|:|:.:|||||||:.|||..||.||::
  Fly  1043 PDTKCHNVLLALTPATRMAFIFIQMYFIFLNNEQIKVYRYKIIARFGLMHMIGTNLAVWLNVLIQ 1107

  Fly   423 ETKHEIFHISQHEVDPAHDLVIHNSSMSRTDWAAVNESLHQHHHHHALNNTLVANVSSVIVNMTI 487
            ||||||             |..:|.. :||  ..::..:..|...||:                |
  Fly  1108 ETKHEI-------------LTFYNPE-NRT--LRISHRIPGHSRGHAI----------------I 1140

  Fly   488 TPSPT-----PAAFSG------CSRTTIMGALVQQLSPFLFPCTIEYSLICAVILFEMWKTVKSI 541
            ...||     |....|      |.||.|:|.|||..||||||||||||||||.||:.||:::...
  Fly  1141 QHDPTAHLRVPRGLKGPYQIFECRRTNIIGTLVQDASPFLFPCTIEYSLICAAILYVMWRSISRP 1205

  Fly   542 PDIDKTRKNSVKPAAAKPAHHFSVDCSQSHKGLFFGILIIVMTIISMIMYFVLYTQPGYELVATQ 606
            ......|.:.:.....:..||:||||:::|||||.||||:|:||||:|::|||.::|.:..:|..
  Fly  1206 QTPTPQRPDMISSPMKRSPHHYSVDCARAHKGLFVGILILVLTIISLIIFFVLISRPEFVAMAVT 1270

  Fly   607 EVTLWETFMYFMCAAAVITGMILMRDLRYIKNTSDEHHSMDLDNLLLIVAQTGVYLYGMFSILGS 671
            |||:.|..:|.....|.:.|||.:|.|:|     |.:.|..||::||:.||||.:||.:|:::..
  Fly  1271 EVTICELLIYGTATIATLVGMIQIRHLQY-----DAYRSFSLDDILLVGAQTGSFLYNIFTVIAG 1330

  Fly   672 YFA-KWD--TVPDRVEGIIAEVFGVVQTSLQTMFILHSSHRRCRGTNQVRRKPGREIITFLLVAN 733
            :|. :.|  .||      |..:..:|||:.||||||.:|.|:......:|:||||||:||:||.|
  Fly  1331 HFTLRSDDMLVP------INALASIVQTACQTMFILDASRRQAVSPEHLRKKPGREIVTFMLVVN 1389

  Fly   734 IAIWFVNTLIKGRAVFRESH---LEFFGVWGWTIITHISMPLAIFYRFHSTICLFEVWKITYKAK 795
            :|:|.::||.|.||   |||   |.|:|:|.||||||:|||||||||||||:||.|:||..||.|
  Fly  1390 LAMWAISTLEKSRA---ESHPIQLNFYGLWAWTIITHVSMPLAIFYRFHSTVCLCEIWKRAYKLK 1451

Fly 796 795
Fly 1452 1451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:281218	205/464 (44%)
OtopLc	NP_001303575.1	Otopetrin	1015..1434	CDD:281218	205/464 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I2171
eggNOG	1	0.900	-	-		E1_KOG4740
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D22651at6960
OrthoFinder	1	1.000	-	-		FOG0001932
OrthoInspector	1	1.000	-	-		mtm6364
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR21522
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X278
	8	7.920