Protein Alignment OtopLb and Otop3

DIOPT Version :9

• Sequence 1: NP_608758.1
• Gene: OtopLb / 33539
• FlyBaseID: FBgn0031514
• Length: 797
• Species: Drosophila melanogaster
• Sequence 2: NP_081408.2
• Gene: Otop3 / 69602
• MGIID: 1916852
• Length: 596
• Species: Mus musculus
• Alignment Length: 674
• Identity: 143/674 - (21%)
• Similarity: 234/674 - (34%)
• Gaps: 237/674 - (35%)

  Fly   221 AKSFQAKQQKDKNRRTGNDAISSALSATYCKLLVLLG---VCLPITEVISDQIPTYVYQG----F 278
            |:.|....::|:..:......|..|:..    :|.||   :|..|...:|      |..|    .
Mouse    51 ARHFSLLLRRDRQAQKAGQLFSGLLALN----VVFLGGAFICSMIFNKVS------VTLGDVWIL 105

  Fly   279 YVYLYVGSILFVIFLYISAFRNRSLFNALKDYHEKNSNVHLKHKV----THFGSFYLRVGAIAFA 339
            ...|.|.|:|::::..:...|.                   .|.|    .|.|..::|...:.|.
Mouse   106 LAALKVLSLLWLLYYTVGTTRK-------------------PHAVLYRDPHAGPIWVRGSLVLFG 151

  Fly   340 IGTMVYSGLEFGQFFELNGHPGCRDVFVAITPICRMVLCIAQVQFIFLNTTYMDMARH-----KV 399
            ..|:..:....|  :::: |..|:.....|.|...:|..|.|...::         ||     :|
Mouse   152 SCTVCLNIFRMG--YDVS-HIHCKSEVELIFPAIEIVFMIIQTWVLW---------RHCKDCVQV 204

  Fly   400 TSRF---GLMHMVATNLCEWLYVLVEETKHEIFHISQHEVDPAHDLVIHNSSMSRTDWAAVNESL 461
            .:.|   |||..:||||..|:.                                    |..|:|:
Mouse   205 QTNFTRCGLMLTLATNLLMWVL------------------------------------AVTNDSM 233

  Fly   462 HQHHHHHALNNTLVANVSSVIVNMTITPSPT--------PAAFSG-------CSRTTI-----MG 506
            |:.         :.|.:.:::...::....|        |...||       |..||:     .|
Mouse   234 HRE---------IEAELDALMEKFSVLQCRTCLRCCLFLPYLLSGNGTNTCMCLNTTVCEVFRKG 289

  Fly   507 ALVQQLSPFLFPCTIEYSLICAVILFEMWKTVKSIPDIDKTRKNSVKPAAAKPAHHFSVDCSQSH 571
            .|:      |:|.:.||.|||..:||.|||.|.             :..||....|.:....:.|
Mouse   290 YLM------LYPFSTEYCLICCAVLFVMWKNVS-------------RSLAAHTGAHPNRSPFRLH 335

  Fly   572 KGLFFGILIIVMTIISMIMYFVLY----TQPGYELVATQEVTLWETF-------MYFMCAAAVIT 625
             |..||.|:.::.:::.:..|||:    :.|.   :|.|..||:..|       |...|.|....
Mouse   336 -GTIFGPLLGLLALVAGVCVFVLFQIEASGPD---IARQYFTLYYAFYVAVLPTMSLACLAGTAI 396

  Fly   626 GMILMRDLRYIKNTSDEHHSMDLDNLLLI---VAQTGVYLYGMFSILGSYFAKWDTVPDRV--EG 685
            ..:..|:|..:||.     :..||.:||:   :.|.|:..:.:.:|:.       |.|..:  :.
Mouse   397 HGLEERELDTLKNP-----TRSLDVVLLMGAALGQMGIAYFSIVAIVA-------TQPHELLNQL 449

  Fly   686 IIA-EVFGVVQTSLQTMFILHSSHRR-----------------------CRGTNQVRRKPGR--- 723
            |:| .:..::|...|.:||:...|||                       .|...|..|:..|
Mouse   450 ILAYSLLLILQHITQNLFIIEGLHRRPLWEPAVSGVMEKQDVELPRRGSLRELGQDLRRASRAYI 514

  Fly   724 --------------EIITFLLVANIAIW----------FVNTLIKGRAVFRESHLEFFGVWGWTI 764
                          ||..||::.||.:|          |.|.|.|          :|:|...|..
Mouse   515 HSFSHLNWKRRMLKEISLFLILCNITLWMMPAFGIHPEFENGLEK----------DFYGYRTWFT 569

  Fly   765 ITHISMPLAIFYRFHSTICLFEVW 788
            |.:..:||.:|||.||...|.||:
Mouse   570 IVNFGLPLGVFYRMHSVGGLVEVY 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:281218	115/542 (21%)
Otop3	NP_081408.2	Otopetrin	143..582	CDD:281218	114/540 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4117
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8758
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.930